The determinants of blood pressure response to exercise

Tuka, Vladimír; Rosa, Ján; Dědinová, Marika; Matoulek, Martin

doi:10.1016/j.crvasa.2015.03.010

Cited by 6 publications

(6 citation statements)

References 16 publications

(14 reference statements)

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“…This finding is not surprising, as it is known that the set-point for blood pressure regulation is set higher in patients with longstanding hypertension (Albaghdadi 2007, Brands 2012. In our population of patients with PA, BP increased from already elevated SBP 0 to 1.0 Watt/kg by a mean of 32 mmHg, which is slightly higher than expected (Tuka et al 2015).…”

Section: Discussioncontrasting

confidence: 48%

Lower Physical Fitness in Patients With Primary Aldosteronism Is Linked to the Severity of Hypertension and Kalemia

Tuka

Matoulek²,

Zelinka³

et al. 2017

Physiol Res

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Hypokalemia as a typical feature of primary aldosteronism (PA) is associated with muscle weakness and could contribute to lower cardiopulmonary fitness. The aim of this study was to describe cardiopulmonary fitness and exercise blood pressure and their determinants during a symptom-limited exercise stress test in patients with PA. We performed a cross-sectional study of patients with confirmed PA who were included before adrenal vein sampling on whom a symptom-limited exercise stress test with expired gas analysis was performed. Patients were switched to the treatment with doxazosin and verapamil at least two weeks before the study. In 27 patients (17 male) the VO2peak was 25.4±6.0 ml/kg/min which corresponds to 80.8±18.9 % of Czech national norm. Linear regression analysis shows that VO2peak depends on doxazosin dose (DX) (p=0.001) and kalemia (p=0.02): VO2peak = 4.2 – 1.0 * DX + 7.6 * Kalemia. Patients with higher doxazosin doses had a longer history of hypertension and had used more antihypertensives before examination, thus indicating that VO2peak also depends on the severity of hypertension. In patients with PA, lower cardiopulmonary fitness depends inversely on the severity of hypertension and on lower plasma potassium level.

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Section: Discussioncontrasting

confidence: 48%

Lower Physical Fitness in Patients With Primary Aldosteronism Is Linked to the Severity of Hypertension and Kalemia

Tuka

Matoulek²,

Zelinka³

et al. 2017

Physiol Res

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“…Действительно, по нашим данным, индекс массы тела был достоверно больше в группе ГРН, однако различий в гендерном составе, возрасте и частоте курения не выявлено. При этом результаты работы согласуются с публикацией Tuka V, et al, где сообщается, что степень повышения АД при нагрузке зависит в первую оче- редь от исходных цифр АД, и в меньшей степени от площади поверхности тела и возраста [13]; в нашем исследовании значения САД в начале теста были достоверно выше в группе ГРН. Несомненно, у пациентов с установленной ГБ и высоким нормальным АД ГРН наблюдается чаще, но она также наблюдается и у пациентов без ГБ [3,12].…”

Section: Discussionunclassified

Cardiovascular risk profiles and stress echocardiography results in patients with hypertensive response to exercise

et al. 2021

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Aim. To compare markers of high cardiovascular risk and stress echocardiography results depending on the type of blood pressure (BP) response to exercise in patients without obstructive coronary artery disease.Material and methods. Our single-center cross-sectional study included 96 patients without hemodynamically significant coronary artery stenosis according to coronary angiography or multislice computed tomography angiography. All patients underwent physical examination, cardiovascular risk stratification, electrocardiography, extracranial cerebrovascular ultrasound, echocardiography, treadmill exercise stress echocardiography.Results. According to the test results, the patients were divided into groups with a hypertensive response (n=41) and a normal response to exercise (n=55). Patients with hypertensive response to exercise had significantly higher values of left ventricular mass index (100,0 (90,0; 107,0) g/m2 vs 76,0 (68,0; 91,0) g/m2, p<0,0000001) and left atrial volume index (36,7 (32,0; 46,0) ml/m2 vs 29,7 (26,3; 32,0) ml/m2, p=0,000003). There was also a higher level of cardiovascular SCORE risk (5,0 (2,0; 6,0) vs 2,0 (1,0; 3,0), p=0,004); patients more often had associated clinical conditions (36,6% vs 12,7%, χ2=7,57, p=0,006) and left ventricular diastolic dysfunction (39,02% vs 78,18%, χ2=15,21, p=0,0001). Pathological BP increase during stress echocardiography was associated with worse exercise tolerance (7,4 (5,6; 10,0) METs vs 10,2 (8,4; 11,95) METs, p=0,000041) and more frequent transient regional contractility impairment (46,34% vs 1,8%, p<0,00001), mainly of the lateral and inferior left ventricular walls.Conclusion. Despite the absence of coronary artery stenosis, patients with hypertensive response to exercise are significantly more likely to have markers of high cardiovascular risk and require more careful monitoring of risk factors. Also, the hypertensive response to exercise is associated with more frequent regional contractility impairment even without coronary artery stenosis.

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“…40 An abnormal increase in BP during exercise is an indicator of endothelial dysfunction. 41 Commonly used exercise tests: These tests, for the sake of convenience, may be divided into two categories: (1) tests which can be done at the clinic level/in the field with a minimum of equipment and (2) those done in a laboratory using sophisticated equipment like the bicycle ergometer or the tread mill.…”

Section: Physiology Of Cardiovascular Changes During Exercisementioning

confidence: 99%

Cardiovascular Responses to Commonly Used Tests In and Outside of the Laboratory Settings

Dikshit

2022

ANAMS

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Several tests are available for assessing cardiovascular response to various interventions which may be given in the laboratory, or outside of it in the field. The tests are meant to excite or deactivate cardiovascular and other sensory receptors which signal the central mechanisms. They have been found useful in generating data to study cardiovascular effects on subjects exposed to specialized physical training (e.g., athletes), in the evaluation of people engaged in special occupations such as pilots, astronauts, and other military personnel, and in training undergraduate and postgraduate students. If the response does not fit into the physiological norm, it may reflect a temporary aberration, or a more serious defect in the cardiovascular control mechanism because of disease. Interpretation of data generated may vary between various operators/observers. Here, an attempt has been made to bring out responses of the cardiovascular system to the commonly used tests, and their applicability in clinical situations.

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The determinants of blood pressure response to exercise

Cited by 6 publications

References 16 publications

Lower Physical Fitness in Patients With Primary Aldosteronism Is Linked to the Severity of Hypertension and Kalemia

Lower Physical Fitness in Patients With Primary Aldosteronism Is Linked to the Severity of Hypertension and Kalemia

Cardiovascular risk profiles and stress echocardiography results in patients with hypertensive response to exercise

Cardiovascular Responses to Commonly Used Tests In and Outside of the Laboratory Settings

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