The Detection of platelet defects in patients with mild bleeding disorders

The discovery of the antiplatelet effect of aspirin: a personal reminiscence

“…The latter was provided to me during one of our weekly string quartet sessions by Sandy Shapiro, who was at the National Institutes of Health at the time. A report of these patients with platelet factor 3 deficiency, then called thrombopathia, was published in the American Journal of Medicine [3].…”

Platelet Factor 3 in Glanzmann’s Thrombasthenia

“…However, poor PF3 re lease in GT noted by various workers [2,3,[9][10][11][12] has been recognised as a constituent defect of the disorder [27]. Congenital [27][28][29] and he reditary [30] PF3 deficiency (deficit thrombopathy) associated with se vere bleeding have been described and are considered as rare platelet disorders. Congenital PF3 deficiency associated with absence of aggrega tion presently seen has not yet been reported.…”