The detection of human papillomavirus 16 DNA in erythroplasia of Queyrat invading the urethra

Analysis of p53 and bcl‐2 protein expression in the non‐tumorigenic, pretumorigenic, and tumorigenic keratinocytic hyperproliferative lesions

“…In normal skin, bcl‐2 expression in melanocytes and basal keratinocytes vs. its lack in superficial keratinocytes agrees with other groups. This bcl‐2 protein expression pattern highlights its cytoprotective role in the former while committing the latter to apoptosis 1–23 …”

“…The non‐tumorigenic lesions include psoriasis vulgaris (PV), verruca vulgaris (VV), chronic dermatitis (CD), seborrheic keratosis (SK), lichen planus (LP), epidermo‐ dysplasia verruciformis (EDV), condyloma acuminata (CA), and lichen simplex chronicus (LSC). The human papilloma virus (HPV) is a member of the papova group of viruses associated with EDV and CA 3,4 . The EDV‐associated HPVs can be divided into two groups.…”

“…Although many reports suggest the involvement of bcl‐2 and p53 proteins in the pathogenesis of several benign and malignant keratinocytic lesions, 1–9 our knowledge about the expression patterns of bcl‐2 and p53 in these lesions is still lacking. In this study, we hypothesized that the expression of apoptosis‐linked proteins (p53 and bcl‐2) is altered in the keratinocytic hyperproliferative lesions.…”

Erythroplasia of Queyrat with Urethral Involvement: Treatment with Carbon Dioxide Laser Vaporization

“…Chronic irritation, smegma, poor hygiene, genital herpes simplex, human papillomavirus (HPV), 4–8 heat, friction, trauma, and specific prepuce dermatoses, such as lichen sclerosus or lichen planus, may be risk factors for developing erythroplasia of Queyrat. All cases occur in uncircumcised patients, although the exact role for the absence of circumcision in the pathogenesis of erythroplasia of Queyrat has not been elucidated.…”

Imiquimod 5% Cream in the Treatment of Human Papillomavirus-16-Positive Erythroplasia of Queyrat

“…As pathogenetic factors, chronic irritation, smegma, poor hygiene, friction and trauma have been postulated. More recent data show that EQ has a strong association with the human papillomavirus (HPV) 16 [5, 6, 7, 8]. In a larger study of 13 patients with carcinoma in situ, 11 were tested positive for HPV-16 DNA [9].…”