The Detection of Cantharidin in Biological Specimens

The syntheses and characterization 3β‐(4‐fluorobenzoyloxy)tropane (fluorotropacocaine) and its 3α isomer

“…The fragment ion, m/z 82 may also be produced from the m/z 83 and it was noted that the ratio of mass ions 82/83 was greater in the a isomer which was similarly noted by previous authors for tropacocaine/benzoyltropeine. [13] However, based on EI mass spectral alone it would be difficult to distinguish the two isomers.…”

“…Pseudotropine was prepared by the reduction of tropinone (Sigma Aldrich, Arklow, Wicklow, Ireland) with iso-butanol/sodium. [15] Instrumentation 1 H (600 MHz), 13 C (150 MHz) and 19 F NMR (decoupled, 377 MHz) spectra were recorded on a Bruker AV600 NMR spectrometer using a 5 mm TCI cryoprobe. High resolution electrospray mass spectra (HR-ESIMS) were recorded on by direct injection on an LTQ Orbitrap Discovery (Thermo Fisher, Bremen, Germany).…”

“…It is found in minor amounts, along with its α isomer, benzoyltropeine, in the coca leaf and has been identified as an impurity in cocaine . Previous authors have identified benzoyltropeine, using gas chromatography‐mass spectrometry (GC‐MS), thin layer chromatography (TLC), and nuclear magnetic resonance (NMR), in street heroin samples but no explanation as to its presence was noted …”

“…[9][10][11][12] Previous authors have identified benzoyltropeine, using gas chromatography-mass spectrometry (GC-MS), thin layer chromatography (TLC), and nuclear magnetic resonance (NMR), in street heroin samples but no explanation as to its presence was noted. [13] The occurrence of isomers of recreational drugs is not unusual and this may makes unambiguous identification difficult as reference standards may not be available. [14] Such isomers may be produced deliberately to circumvent laws and improve activity or even inadvertently where the wrong staring material is used or manufacturing conditions are changed.…”

High resolution gas chromatography: Simultaneous detection of narcotics, adulterants, and diluents in street samples

“…In recent years, in fact, an unusual substance, benzoylthropeine, has been detected iin five street samples confiscated in the Florence area and in two samples confiscated in the Siena area, Italy. In addition, some cases of benzoylthropeine contamination of heroin samples have been reported in the United States [2]. The determination 01 diluents (sugars and mannitol) makes it possible, in some cases, to trace the transfer of the narcotic from the first seller to the consumer 111.…”