The Detection, Evaluation, and Management of Dyslipidemia in Children and Adolescents: A Canadian Cardiovascular Society/Canadian Pediatric Cardiology Association Clinical Practice Update

Khoury, Michael; Bigras, Jean‐Luc; Cummings, Elizabeth; Harris, Kevin C.; Hegele, Robert A.; Henderson, Mélanie; Morrison, Katherine M.; St‐Pierre, Julie; Wong, Peter; McCrindle, Brian W.

doi:10.1016/j.cjca.2022.05.002

Cited by 24 publications

(16 citation statements)

References 58 publications

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“…Recent guidelines such as the Canadian Cardiovascular Society and the Canadian Pediatric Cardiology Association recommended the use of non-fasting LDL-C and/or non-HDL-C as the initial step for pediatric dyslipidemia screening [ 11 ]. The non-fasting state is often associated with TG levels greater than 1,5 mmol/L, which underestimates the level of LDL-C [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Altogether, it highlights the importance of obtaining reference values that are specifically tailored to the non-fasting state, particularly for non-HDL-C. The Canadian Cardiovascular Society (CCS) and the Canadian Pediatric Cardiology Association (CPCA) updated and approved NHBLI screening strategies [ 11 ]. Indeed, a non-fasting lipid profile is recommended and can be easily added to routine medical practices [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…The Canadian Cardiovascular Society (CCS) and the Canadian Pediatric Cardiology Association (CPCA) updated and approved NHBLI screening strategies [ 11 ]. Indeed, a non-fasting lipid profile is recommended and can be easily added to routine medical practices [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Establishing non-fasting reference values for plasma lipids levels based on age, sex, and puberty stage in a French-Canadian pediatric population

Bouhour,

Plantefève,

Gillet

et al. 2024

Lipids Health Dis

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Background Dyslipidemias, including familial hypercholesterolemia (FH), are a significant risk factor for cardiovascular diseases. FH is a genetic disorder resulting in elevated levels of low-density lipoprotein cholesterol (LDL-C) and an increased probability of early cardiovascular disorders. Heterozygous familial hypercholesterolemia (HeFH) is the most common form, affecting approximately 1 in 250 individuals worldwide, with a higher prevalence among the French-Canadian population. Childhood is a critical period for screening risk factors, but the recommendation for non-fasting screening remains controversial due to a lack of specific reference values for this state. This study aims to establish reference values for lipid levels in non-fasting children from Sherbrooke, Quebec, Canada, that will be specific for sex, age, and pubertal stages. Methods Blood samples and corresponding anthropometric data were collected from 356 healthy children aged from 6 to 13. They were categorized either into two age groups: Cohort 6–8 and Cohort 9–13, or into pubertal stages. Reference values, specifically the 2.5th, 5th, 10th, 50th, 90th, 95th, and 97.5th percentiles were determined using the CLSI C28-A3 guidelines. Results Lipid profiles did not significantly differ between sexes, except for higher levels of high-density lipoprotein (HDL-C) in boys within Cohort 6–8. HDL-C levels significantly increased, while LDL-C and non-HDL-C levels significantly decreased in both sexes with age. Non-fasting age- and pubertal stages-specific reference values were established. Conclusion This study established reference intervals for lipid markers in non-fasting state within the pediatric French-Canadian population. These findings could be used in dyslipidemia screening in daily practice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Establishing non-fasting reference values for plasma lipids levels based on age, sex, and puberty stage in a French-Canadian pediatric population

Bouhour,

Plantefève,

Gillet

et al. 2024

Lipids Health Dis

View full text Add to dashboard Cite

show abstract

“…Lp(a) has already been recognized as a useful risk factor when considering statin treatment thresholds in children with familial hypercholesterolemia, 12,13 particularly because Lp(a) has been shown to strongly contribute to ASCVD risk in adults with familial hypercholesterolemia. 14 The findings in the present study by Raitakari et al emphasize that Lp(a) not only is associated with an increased risk of ASCVD in adulthood but also acts independently and additively with LDL cholesterol.…”

Section: Where Do We Go From Here?mentioning

confidence: 99%

“…These findings support the consideration of Lp(a) screening along with existing universal lipid screening recommendations in childhood. 10,12,13 Unlike other cardiovascular risk factors screened in childhood (eg, LDL cholesterol and blood pressure), the genetic determination and stability of Lp(a) levels mean that screening would need to occur only once. Doing so would permit more precise risk stratification and earlier and more aggressive management of other cardiovascular risk factors.…”

Section: Where Do We Go From Here?mentioning

confidence: 99%