The detection and prognosis of small pancreatic carcinoma

Ariyama, J; Suyama, Masafumi; Ogawa, Kaoru; Ikari, Takaaki; Nagaiwa, Jiro; Fujii, Daigo; Tsuchida, Akira

doi:10.1007/bf02924218

Cited by 44 publications

(1 citation statement)

References 12 publications

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“…It is worth the effort to find an efficient screening method for the population at risk scoring between 50 and 75. The best example to justify this effort is that Ariyama et al [ 297 , 298 ] found excellent survival rates in 79 patients with tumors of less than 1 cm who underwent surgical resection.…”

Section: Discussionmentioning

confidence: 99%

Earlier Diagnosis of Pancreatic Cancer: Is It Possible?

Koltai

2023

Cancers

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Pancreatic ductal adenocarcinoma has a very high mortality rate which has been only minimally improved in the last 30 years. This high mortality is closely related to late diagnosis, which is usually made when the tumor is large and has extensively infiltrated neighboring tissues or distant metastases are already present. This is a paradoxical situation for a tumor that requires nearly 15 years to develop since the first founding mutation. Response to chemotherapy under such late circumstances is poor, resistance is frequent, and prolongation of survival is almost negligible. Early surgery has been, and still is, the only approach with a slightly better outcome. Unfortunately, the relapse percentage after surgery is still very high. In fact, early surgery clearly requires early diagnosis. Despite all the advances in diagnostic methods, the available tools for improving these results are scarce. Serum tumor markers permit a late diagnosis, but their contribution to an improved therapeutic result is very limited. On the other hand, effective screening methods for high-risk populations have not been fully developed as yet. This paper discusses the difficulties of early diagnosis, evaluates whether the available diagnostic tools are adequate, and proposes some simple and not-so-simple measures to improve it.

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Section: Discussionmentioning

confidence: 99%