The detection and analysis of differential regulatory communities in lung cancer

Integrated Bioinformatical Analysis Identifies GIMAP4 as an Immune-Related Prognostic Biomarker Associated With Remodeling in Cervical Cancer Tumor Microenvironment

“…The GIMAP genes are mapped on a chromosomal region within 7q35-7q36.1, coding for proteins primarily expressed in the immune system, which are closely correlated with the immune-related biological process such as Th cell differentiation, apoptosis of peripheral lymphocytes, and thymocyte development (Dion et al, 2005;Nitta et al, 2006;Filen et al, 2009). Additionally, except for their contribution to regulating the immune system, GIMAPs were also researched to serve as tumor suppressor genes, influencing the initiation and development of various cancers (Taniwaki et al, 2006;Shiao et al, 2008;Lan et al, 2020;Megarbane et al, 2020), whose expression was at deficient levels in various cancer tissues and cell lines (Krucken et al, 2004). GIMAP4 is the sole gene investigated to possess real GTPase activity among the GIMAP family (Heinonen et al, 2015), but its biological characteristics in CC are still far from clear.…”

“…GIMAP4 played an essential role in regulating lymphocyte apoptosis and was reported to be closely connected with the immune biological process of Th1/Th2 differentiation, and there appeared upregulation and downregulation of GIMAP4 under Th1-and Th2-promoting circumstance, respectively (Filen et al, 2009;Filen and Lahesmaa, 2010). Increasing evidence had revealed that GIMAP4 seemed to serve as a protective factor in several kinds of cancer, including lung cancer (Krucken et al, 2004;Lan et al, 2020). However, there were few available studies of GIMAP4 in CC until now.…”