The design strategies and biological applications of probes for the gaseous signaling molecule hydrogen sulfide

Abstract

H2S, the smallest and simplest biological thiol in the living system, is the third member of the family of signaling mediators. H2S participates in the regulation of a series of...

Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies

“…Some other imaging modalities, such as photoacoustic imaging (PAI), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), and combined imaging, have also been explored for potential use in H 2 S detection and diagnosis. Recently, due to the increased levels of H 2 S in CRC, many probes and H 2 S-based in vivo diagnosis have been developed to detect intracellular levels of H 2 S in CRC cells [ [ 181 , 253 , 254 ]]. In this section, we summarize the H 2 S-activatable probes relevant in the field of CRC research ( Table 3 ) and described in detail below.…”

“…Researchers have developed a probe with a new imaging modality, PA imaging, which relies on the translation of excitation light into ultrasonic waves based on the PA effect. This imaging method combines the advantages of high resolution of optical imaging and high penetration depth of ultrasound imaging for deep tissues and whole animals imaging [ 254 , 281 ].…”

A highly selective and sensitive endoplasmic reticulum-targeted probe reveals HOCl- and cisplatin-induced H2S biogenesis in live cells

“…Many different research groups have successfully developed fluorescent probes to sense H 2 S based on different reaction types. 3,12,18,[35][36][37][38][39][40][41][42][43][44][45][46] In general, different sensing reactions have their intrinsic advantages and limits. 3 For example, the selectivity for thiolysis of NBD ether toward H 2 S over glutathione (GSH) is not very high.…”

Novel fluorescent probe based on dicoumarin for detection of hydrogen sulfide in real samples

“…Hydrogen sulfide (H 2 S), a pungent gas that smells like rotten eggs, has long been regarded as one of the major pollutants in the atmosphere. [ 1 ] At the same time, H 2 S is the third gas signaling molecule after nitric oxide (NO), and carbon monoxide (CO), and is the smallest and most basic biological thiol in life systems. [ 2 ] H 2 S is an essential fulcrum in human physiology to balance health and disease, as it is produced endogenously in almost all organs and tissues of the human body through enzymatic and non‐enzymatic pathways.…”