The Design of Nanostructured Metronidazole-Loaded HPC/Oxide Xerogel Composites: Influence of the Formulation Parameters on In Vitro Characterisation

Abstract

Abstract. In this study, oxide and polymer/oxide xerogels with metronidazole were prepared and examined as carriers of drug for the local application to the bone. The nanoporous SiO 2 -CaO-P 2 O 5 and HPCSiO 2 -CaO-P 2 O 5 xerogel materials with different amounts of the polymer [hydroxypropyl cellulose (HPC)] were prepared using the sol-gel technology, and their physicochemical properties were characterised with respect to chemical structure [by Fourier transform infrared spectroscopy (FTIR)], porosity and the specific surface area of solids (BET), crystallinity [by X-ray powder diffraction (XRD)], morphology [by scanning electron microscope (SEM)] and the in vitro release of the metronidazole over time (by UV-vis spectroscopy, in the ultraviolet light region). HPC-modified oxide xerogels as the carriers of drug showed slower release of metronidazole, due to the structure and stronger interactions with drug as compared with the pure oxide xerogel. Kinetic analysis indicated diffusional mechanism of drug release from all xerogel carriers. HPC addition to the oxide material resulted in a decrease in the porosity and improved the bioactive properties of xerogels. Obtained results for xerogel composites suggest that the metronidazole-loaded xerogels could be attractive candidates for local delivery systems particularly to a bone.

Determination of characterization, antibacterial and drug release properties of POSS- based film synthesized with sol-gel technique

“…For the release of metronidazole, silica, silica/polydimethylsiloxane and silica/ polydimethylsiloxane/calcium cryogels were examined as polymeric carriers [37]. Nano-porous SiO2-CaO-P205 and HPC-SiO2-CaO-P2O5 xerogeller were prepared for the release of metronidazole [38]. POSS-based carrier systems that can offer high efficiency with low drug dosage have been developed by Karaca Açarı et al [39].…”

“…For the release of metronidazole, silica, silica/polydimethylsiloxane and silica/ polydimethylsiloxane/calcium cryogels were examined as polymeric carriers [ 37 ]. Nanoporous SiO 2 -CaO-P 2 0 5 and HPC-SiO 2 -CaO-P 2 O 5 xerogels were prepared for the release of metronidazole [ 38 ]. In this study, POSS-based antibacterial film synthesis was carried out, especially for biomedical surface coating areas.…”

Impact of supramolecular interactions on swelling and release behavior of UPy functionalized HEMA‐based hydrogels

“…It should be mentioned that the PH‐S2 sample was not considered for release study, due to its low elastic modulus and compression strength. Investigation of loading solutions of metronidazole by UV spectroscopy at a wavelength of 320 nm showed that the loading contents of the drug were 28.65%, 31.32%, and 45.3% for PH‐C6, PH‐S6, and PH‐S10, respectively. These results show that the loading capacities of the hydrogels were in complete agreement with their corresponding equilibrium swelling ratios (Figures and C).…”

Formulation and In Vitro Characterization of Bioactive Mesoporous Silica with Doxorubicin and Metronidazole Intended for Bone Treatment and Regeneration

“…The choice of the aforementioned substances is dictated by our earlier results of the dissolution of the gel of the oxide carrier (15,16). We found that due to the construction and interaction with the matrix oxide, ChD was released much slower than MT.…”

“…In addition to this, granulated material results in reduced dustiness and sustained drug release (14). Therefore, in this study, we selected ethyl cellulose (EC) as the binding agent due to its widespread use as a binder in wet granulation and the use of cellulose derivatives as components of bioactive materials (15).…”