Abstract:Alzheimer's disease (AD) is a devastating neurological disorder where a pathological hallmark is the occurrence of amyloid‐β (Aβ) peptide deposits, also known as Aβ plaques. The Aβ peptide is known to self‐associate and aggregate in solution, a phenomenon that is accelerated in the presence of metal ions, in particular Fe, Cu, and Zn. Furthermore, these micronutrient metals are found in elevated concentration within Aβ plaques, relative to nearby healthy tissues. Therapeutic approaches have sought to exploit t… Show more
Ru(ii)–arene azole complexes demonstrated that decreased affinity to serum albumin led to an increase in preventing amyloid-β aggregation and cytotoxicity.
Ru(ii)–arene azole complexes demonstrated that decreased affinity to serum albumin led to an increase in preventing amyloid-β aggregation and cytotoxicity.
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