The design of bioreactors

Rossi, G.

doi:10.1016/s0304-386x(00)00161-4

Cited by 43 publications

(15 citation statements)

References 14 publications

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“…Conventional STRs are prone to impeller flooding, a phenomenon characterized by gas rapidly flowing axially upwards past the impeller with no radial discharge, and the formation of stagnant zones [98,99]. There are also other acknowledged limitations when using STRs including gas channelling, resulting in reduced gas dissolution and poor bulk mixing [17,100]. This requires implementation of different scale-up strategies depending on the specific bioprocess [101,102].…”

Section: Barriersmentioning

confidence: 99%

Biological processing in oscillatory baffled reactors: operation, advantages and potential

Harvey

et al. 2013

Interface Focus.

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The development of efficient and commercially viable bioprocesses is essential for reducing the need for fossil-derived products. Increasingly, pharmaceuticals, fuel, health products and precursor compounds for plastics are being synthesized using bioprocessing routes as opposed to more traditional chemical technologies. Production vessels or reactors are required for synthesis of crude product before downstream processing for extraction and purification. Reactors are operated either in discrete batches or, preferably, continuously in order to reduce waste, cost and energy. This review describes the oscillatory baffled reactor (OBR), which, generally, has a niche application in performing ‘long’ processes in plug flow conditions, and so should be suitable for various bioprocesses. We report findings to suggest that OBRs could increase reaction rates for specific bioprocesses owing to low shear, good global mixing and enhanced mass transfer compared with conventional reactors. By maintaining geometrical and dynamic conditions, the technology has been proved to be easily scaled up and operated continuously, allowing laboratory-scale results to be easily transferred to industrial-sized processes. This is the first comprehensive review of bioprocessing using OBRs. The barriers facing industrial adoption of the technology are discussed alongside some suggested strategies to overcome these barriers. OBR technology could prove to be a major aid in the development of commercially viable and sustainable bioprocesses, essential for moving towards a greener future.

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Section: Barriersmentioning

confidence: 99%

Biological processing in oscillatory baffled reactors: operation, advantages and potential

Harvey

et al. 2013

Interface Focus.

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“…The rotating drum bioreactor (Biorotor) [157,158] is a baffled cylindrical barrel with an aeration inlet (CO2 and O2) at one end and an air outlet at the other end. The cylinder sits on rollers and during rotation the baffles lift solids and then discharge them to fall through the solution, maximising mixing, eliminating "dead" zones and minimising shear stresses on bacterial cells.…”

Section: Technology Developmentsmentioning

confidence: 99%

“…The cylinder sits on rollers and during rotation the baffles lift solids and then discharge them to fall through the solution, maximising mixing, eliminating "dead" zones and minimising shear stresses on bacterial cells. Tests carried out with 30% solids suspension of pyrite yielded solubilisation rates an order of magnitude greater than thought possible [158]. The rotating bioreactor has attracted recent attention with the development of a modified continuous reactor capable of processing a 40% solids suspension [159].…”

Section: Technology Developmentsmentioning

confidence: 99%

Review of Biohydrometallurgical Metals Extraction from Polymetallic Mineral Resources

Watling

2014

Minerals

132

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This review has as its underlying premise the need to become proficient in delivering a suite of element or metal products from polymetallic ores to avoid the predicted exhaustion of key metals in demand in technological societies. Many technologies, proven or still to be developed, will assist in meeting the demands of the next generation for trace and rare metals, potentially including the broader application of biohydrometallurgy for the extraction of multiple metals from low-grade and complex ores. Developed biotechnologies that could be applied are briefly reviewed and some of the difficulties to be overcome highlighted. Examples of the bioleaching of polymetallic mineral resources using different combinations of those technologies are described for polymetallic sulfide concentrates, low-grade sulfide and oxidised ores. Three areas for further research are: (i) the development of sophisticated continuous vat bioreactors with additional controls; (ii) in situ and in stope bioleaching and the need to solve problems associated with microbial activity in that scenario; and (iii) the exploitation of sulfur-oxidising microorganisms that, under specific anaerobic leaching conditions, reduce and solubilise refractory iron(III) or manganese(IV) compounds containing multiple elements. Finally, with the successful applications of stirred tank bioleaching to a polymetallic tailings dump and heap bioleaching to a polymetallic black schist ore, there is no reason why those proven technologies should not be more widely applied.

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“…Sin embargo, operar con densidades de pulpa mayores al 20% en reactores de tanque agitado no ha tenido buenos resultados (Rossi, 2001;Deveci, 2004) debido a un excesivo número de partículas de mineral para un inóculo de tamaño constante, ya que la fricción entre las partículas disminuye la relación bacteria/sólido y la velocidad de solubilización; debido a que estos factores causan daño celular y limitan las velocidades de transferencia de oxígeno incrementando a su vez el tiempo de biooxidación (Hansford et. al., 1995, Rossi, 2001Deveci, 2004;Arroyave, 2008).…”

Section: Introductionunclassified

Determinación de la capacidad oxidativa de un consorcio microbiano nativo sobre un mineral aurífero refractario

Gabriela

Paulina

2016

Proceedings of the 14th LACCEI International Multi-Conference for Engineering, Education, and Technology: “Engineering Innovati

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Abstract-Biooxidation is known as an alternative process (pre-treatment) for gold recovery from refractory ores, which had increased in developing countries. This process uses acidophilic microorganisms, which allows the gold presetn in a sulfurized ore matrix become available for the cyanidation process. This research had two main goals which were to isolate the native acidophilic microorganism from a natural acidic drainage and to determine its oxidation capacity in a stirring tank reactor by varying the pulp density (% w/v) to get better solubility of the mineral and greater gold recovery. For the isolation of acidophilic microorganisms, a Silverman and Lundgren (1959) medium culture -adjusted to pH 1.8 -was used; ferrous sulfate (FeSO4 * 7H2O) was used as an energy source. For the adaptation of these microorganisms and in order for them to reach optimal growing rates (u), successive cell replications were performed at the time the color of the culture changed from green to red. The biooxidation tests were conducted by using the following fixed variables: pH ( Abstract-Biooxidation is known as an alternative process (pre-treatment) for gold recovery from refractory ores, which had increased in developing countries. This process uses acidophilic microorganisms, which allows the gold presetn in a sulfurized ore matrix become available for the cyanidation process. This research had two main goals which were to isolate the native acidophilic microorganism from a natural acidic drainage and to determine its oxidation capacity in a stirring tank reactor by varying the pulp density (% w/v) to get better solubility of the mineral and greater gold recovery. For the isolation of acidophilic microorganisms, a Silverman and Lundgren (1959) medium culture -adjusted to pH 1.8 -was used; ferrous sulfate (FeSO4 * 7H2O) was used as an energy source. For the adaptation of these microorganisms and in order for them to reach optimal growing rates (u), successive cell replications were performed at the time the color of the culture changed from green to red. The biooxidation tests were conducted by using the following fixed variables: pH (

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The design of bioreactors

Cited by 43 publications

References 14 publications

Biological processing in oscillatory baffled reactors: operation, advantages and potential

Biological processing in oscillatory baffled reactors: operation, advantages and potential

Review of Biohydrometallurgical Metals Extraction from Polymetallic Mineral Resources

Determinación de la capacidad oxidativa de un consorcio microbiano nativo sobre un mineral aurífero refractario

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