The design of additively manufactured lattices to increase the functionality of medical implants

Burton, Hanna E.; Eisenstein, Neil; Lawless, Bernard; Jamshidi, Parastoo; Segarra, Miren A.; Addison, Owen; Shepherd, Duncan E.T.; Attallah, Moataz M.; Grover, Liam M.; Cox, Sophie C.

doi:10.1016/j.msec.2018.10.052

Cited by 96 publications

(50 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A large range of materials are currently available for additive manufacturing, that include metals, ceramics and polymers. Metallic implants have commonly been used in orthopedic applications due to their inherent stiffness; they have traditionally been used for long-term structural applications but recent studies are seeking to increase their biological applications (Cox et al, 2016(Cox et al, , 2017Burton et al, 2019). A number of additively manufactured titanium implants have now been FDA approved, such as the FastForward device for correction of hallux valgus deformities (Smith et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

3D Printed Polyurethane Scaffolds for the Repair of Bone Defects

Cooke

Ramírez-GarcíaLuna

Rangel-Berridi

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Critical-size bone defects are those that will not heal without intervention and can arise secondary to trauma, infection, and surgical resection of tumors. Treatment options are currently limited to filling the defect with autologous bone, of which there is not always an abundant supply, or ceramic pastes that only allow for limited osteo-inductive and-conductive capacity. In this study we investigate the repair of bone defects using a 3D printed LayFomm scaffold. LayFomm is a polymer blend of polyvinyl alcohol (PVA) and polyurethane (PU). It can be printed using the most common method of 3D printing, fused deposition modeling, before being washed in water-based solutions to remove the PVA. This leaves a more compliant, micro-porous PU elastomer. In vitro analysis of dental pulp stem cells seeded onto macro-porous scaffolds showed their ability to adhere, proliferate and form mineralized matrix on the scaffold in the presence of osteogenic media. Subcutaneous implantation of LayFomm in a rat model showed the formation of a vascularized fibrous capsule, but without a chronic inflammatory response. Implantation into a mandibular defect showed significantly increased mineralized tissue production when compared to a currently approved bone putty. While their mechanical properties are insufficient for use in load-bearing defects, these findings are promising for the use of polyurethane scaffolds in craniofacial bone regeneration.

show abstract

Section: Discussionmentioning

confidence: 99%

3D Printed Polyurethane Scaffolds for the Repair of Bone Defects

Cooke

Ramírez-GarcíaLuna

Rangel-Berridi

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…To dynamise bone plates and facilitate the micromotion required to stimulate option healing, current solutions incorporate various mechanics that revolve around increasing the motion around the fixation of the screw to the bone (Bottlang et al, 2009(Bottlang et al, , 2017Döbele et al, 2010). The stiffness modulation of orthopaedic implants and has been broached only once, by varying the lattice design of a hip implant (Burton et al, 2019). The design of biomedical implants for time-varying biological requirements, is something unique to this study, as yet unbroached by DfAM literature.…”

Section: Discussionmentioning

confidence: 99%

“…Whilst AM provides an opportunity to increase the specificity of the design of implants to the patient physiology or pathology, in the literature this is predominately limited to patient specific geometry for example in cranial and maxillofacial implants (Tack et al, 2016). Burton et al (2019), broached the challenge of replicating physiological mechanical properties through lattice design. To date, this is the only example of exploiting the creative design potential of AM, to increase the specificity of implants beyond geometry.…”

Section: Iced19mentioning

confidence: 99%

Design Principles to Increase the Patient Specificity of High Tibial Osteotomy Fixation Devices

Kanagalingam

Shepherd

Fernández-Vicente

et al. 2019

Proc. Int. Conf. Eng. Des.

View full text Add to dashboard Cite

High stiffness fracture fixation devices inducing absolute stability, activate inefficient primary healing and stress shielding. Taking High Tibial Osteotomy as a representative example, review of the clinical literature and mapping the fracture healing process revealed two physically contradicting requirements, which are only partially met by current techniques. Stiffness of the fixation is required immediately after fracture, however in the remodelling phase this can cause stress shielding. Stability is required immediately after fracture, however in the ossification phase less stability is required to stimulate secondary (and more efficient) healing. This study evaluates the use of the TRIZ Inventive Design Principles to overcome these physical contradictions. Six designs concepts were evaluated, of which the Macro-Geometry stiffness modulated design was ranked the highest. This was achieved through spatial decomposition of the problem utilising the Inventive Principles of Asymmetry, Extraction and Local Quality. This study offer perspectives on how to increase the patient specificity of fixation utilising the increased topology freedom of design for additive manufacture (AM).

show abstract

“…[ 87 ] FEA methods have been widely used to optimize the distribution of graded cellular lattice structures and enhance the strength‐to‐weight ratio of FGSs. [ 45,48,88–90 ] Geometrical complexity of predesigned 3D objects results in a computationally cumbersome discretization procedure at the mesh definition stage in FEA. Parthasarathy et al [ 88 ] incorporated a RVE method into FEA for simulation of the stiffness of FGSs with greatly improved computational efficiency.…”

Section: Design Concepts For Fgmammentioning

confidence: 99%

A Review on Functionally Graded Materials and Structures via Additive Manufacturing: From Multi‐Scale Design to Versatile Functional Properties

Yan

Feng

Liu

et al. 2020

Adv Materials Technologies

271

121

View full text Add to dashboard Cite

Functionally graded materials (FGMs) and functionally graded structures (FGSs) are special types of advanced composites with peculiar features and advantages. This article reviews the design criteria of functionally graded additive manufacturing (FGAM), which is capable of fabricating gradient components with versatile functional properties. Conventional geometrical‐based design concepts have limited potential for FGAM and multi‐scale design concepts (from geometrical patterning to microstructural design) are needed to develop gradient components with specific graded properties at different locations. FGMs and FGSs are of great interest to a larger range of industrial sectors and applications including aerospace, automotive, biomedical implants, optoelectronic devices, energy absorbing structures, geological models, and heat exchangers. This review presents an overview of various fabrication ideas and suggestions for future research in terms of design and creation of FGMs and FGSs, benefiting a wide variety of scientific fields.

show abstract

The design of additively manufactured lattices to increase the functionality of medical implants

Cited by 96 publications

References 20 publications

3D Printed Polyurethane Scaffolds for the Repair of Bone Defects

3D Printed Polyurethane Scaffolds for the Repair of Bone Defects

Design Principles to Increase the Patient Specificity of High Tibial Osteotomy Fixation Devices

A Review on Functionally Graded Materials and Structures via Additive Manufacturing: From Multi‐Scale Design to Versatile Functional Properties

Contact Info

Product

Resources

About