The design and discovery of phospholipase A<sub>2</sub> inhibitors for the treatment of inflammatory diseases

Batsika, Charikleia S.; Gerogiannopoulou, Anna-Dimitra D.; Mantzourani, Christiana; Vasilakaki, Sofia; Kokotos, George

doi:10.1080/17460441.2021.1942835

Cited by 26 publications

(21 citation statements)

References 129 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A prospective study illustrated that sPLA2 levels were increased in children with COVID-19 and correlated with its severity (Bonaz et al 2020 ). Thus, PLA2 inhibitors like darapladib and varesplaide could be effective in attenuating inflammatory disorders in COVID-19 (Batsika et al 2021 ; Kuypers et al 2021 ). Hence, CTN could be effective in reducing COVID-19 severity through inhibition of PLA2 activity.…”

Section: Citicoline Oxidative Stress and Hyperinflammationmentioning

confidence: 99%

Citicoline and COVID-19: vis-à-vis conjectured

Al-Kuraishy

Al-Buhadily

Al-Gareeb

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) is a current pandemic disease caused by a novel severe acute respiratory syndrome coronavirus virus respiratory type 2 (SARS-CoV-2). SARS-CoV-2 infection is linked with various neurological manifestations due to cytokine-induced disruption of the blood brain barrier (BBB), neuroinflammation, and peripheral neuronal injury, or due to direct SARS-CoV-2 neurotropism. Of note, many repurposed agents were included in different therapeutic protocols in the management of COVID-19. These agents did not produce an effective therapeutic eradication of SARS-CoV-2, and continuing searching for novel anti-SARS-CoV-2 agents is a type of challenge nowadays. Therefore, this study aimed to review the potential anti-inflammatory and antioxidant effects of citicoline in the management of COVID-19.

show abstract

Section: Citicoline Oxidative Stress and Hyperinflammationmentioning

confidence: 99%

Citicoline and COVID-19: vis-à-vis conjectured

Al-Kuraishy

Al-Buhadily

Al-Gareeb

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

show abstract

“…Furthermore, when COVID-19 patients were treated with Lp-PLA2 inhibitors, analysis revealed the downregulation of glycerol phospholipids and overexpression of lyso phospholipids, as well as free arachidonic acid and oleic acid. The findings ultimately suggested that Lp-PLA2 inhibitors may play a role in COVID-19 [ 95 ].…”

Section: Proposed Role Of Lp-pla2 In Different Pathological Stages Of...mentioning

confidence: 99%

Lp-Pla2 As A Biomarker and Its Possible Associations with Sars-Cov-2 Infection

2022

View full text Add to dashboard Cite

Lp-PLA2 is an enzyme encoded by the PLA2G7 gene located at chromosome 6p12-21, which is included in different signal transduction pathways. The potential of serum levels of Lp-PLA2 as a marker of inflammation quantifying cardio-metabolic risk, renal impairment and oxidative stress has been explored in earlier studies. It has also been used in chronic obstructive pulmonary disease, hepatic disease, metabolic conditions and exercise tolerance. Additionally, it shows promising evidence for the assessment of risk for certain cardiovascular conditions in otherwise seemingly healthy individuals. COVID-19 has affected life and the economy globally. The identification of biomarkers to assess the sickness and treatment plan is the need of the hour. This review summarizes the pathophysiological inter-relationship between serum levels of Lp-PLA2 and COVID-19. The authors hypothesize that the estimation of Lp-PLA2 levels may help in the early identification of risk and thus may play a beneficial role in the proactive management of COVID-19.

show abstract

“…Phospholipase A2 (PLA2) is a superfamily of enzymes with phospholipid decomposition activity. 1 According to their structure and function, phospholipases are mainly divided into four categories: 2,3 cytosolic phospholipase A2 (cPLA2), secreted phospholipase A2 (sPLA2), lipoprotein-associated phospholipase A2 (Lp-PLA2), and calcium-independent phospholipase A2 (iPLA2).…”

Section: Introductionmentioning

confidence: 99%

“…It is a small molecular weight secreted protein with molecular weights of 14–18 kDa and linked by 6–8 disulfide bonds. 3 So far, the human genome has encoded 9 sPLA2 genes, all of which are named in the form of disulfide bonds and the order of discovery, showing different subtypes in human life activities. 4 sPLA2 generally has an N-terminal signal peptide, which is related to the initiation of some functions.…”

Section: Introductionmentioning

confidence: 99%