The descriptive epidemiology of lung cancer and tobacco control: a global overview 2018

Miranda‐Filho, Adalberto; Piñeros, Marion; Bray, Freddie

doi:10.21149/10140

Cited by 36 publications

(30 citation statements)

References 10 publications

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“…Lung carcinoma remains one of the most common causes of mortality worldwide (4). According to estimates from the World Health Organisation (WHO), ~1.7 million people died of lung cancer worldwide in 2018, accounting for 20% of all cancer-associated deaths (5,6). Despite advancements in the diagnosis and treatment, lung carcinoma remains a principal element that contributes to high morbidity and mortality in global malignancies (6,7).…”

Section: Introductionmentioning

confidence: 99%

Downregulated microRNA‑140‑5p expression regulates apoptosis, migration and invasion of lung cancer cells by targeting zinc finger protein 800

et al. 2020

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Despite advances in the diagnosis and treatment in recent years, lung cancer is still one of the primary causes of cancer-associated morbidity and mortality in globally. Abnormally expressed microRNAs (miRNAs/miRs) in tumor tissues serve vital roles in the pathological mechanism of tumors and have become prospective biomarkers for cancer diagnosis. The present study aimed to investigate the effects of the miR-140-5p/zinc finger protein 800 (ZNF800) axis in lung carcinoma, and determine its potential underlying molecular mechanisms. The degree of cell proliferation was assessed via the MTT assay, while the migratory and invasive abilities of lung cancer cells were determined via the Transwell and Matrigel assays. The expression levels of miR-140-5p and ZNF800 were detected via reverse transcription-quantitative PCR and western blot analyses. The results demonstrated that miR-140-5p expression was notably higher in normal human bronchial epithelial cells compared with the respective lung cancer cell lines, H292, PC-9, CL1-5 and H460. Furthermore, miR-140-5p expression increased in the lung cancer cells compared with the control cells following transfection with miR-140-5p mimic. Overexpressing miR-140-5p significantly suppressed the proliferative, invasive and migratory abilities of H460 and PC-9 cells, and stimulated cell apoptosis by upregulating the expression of cleaved-caspase-3. Notably, these effects were reversed following transfection with miR-140-5p inhibitor. miR-140-5p was predicted as a negative regulator of ZNF800, and ZNF800 knockdown significantly suppressed the proliferative and metastatic abilities of lung adenocarcinoma (LUAD) cells, which was comparable to the effects of miR-140-5p mimic. Taken together, these results suggest that miR-140-5p may block the malignant phenotype of LUAD by negatively regulating ZNF800 expression. Thus, the miR-140-5p/ZNF800 axis may be used as an alternative therapeutic target for lung carcinoma in general, and LUAD in particular.

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Section: Introductionmentioning

confidence: 99%

Downregulated microRNA‑140‑5p expression regulates apoptosis, migration and invasion of lung cancer cells by targeting zinc finger protein 800

et al. 2020

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“…Lung cancer incidence and mortality continue to increase worldwide; in 2018, new lung cancer cases accounted for 11.6% of all cancer cases, and lung cancer deaths accounted for 18.4% of all cancer deaths. [1][2][3] Because early clinical manifestations of lung cancer are not typical, early detection and treatment are limited. Chemotherapy is the primary treatment for middle-and late-stage lung cancer.…”

Section: Introductionmentioning

confidence: 99%

<p>Delicaflavone Reverses Cisplatin Resistance via Endoplasmic Reticulum Stress Signaling Pathway in Non-Small Cell Lung Cancer Cells</p>

Wang

Chen

et al. 2020

OTT

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Background: The incidence and mortality of lung cancer continue to increase around the world; in 2018, new lung cancer cases accounted for 11.6% of all cancer cases, and lung cancer deaths accounted for 18.4% of cancer deaths. Cisplatin (DDP) is a first-line chemotherapy drug for lung cancer; however, DDP resistance can lead to a poor prognosis in patients with lung cancer. Therefore, reversing DDP resistance is a treatment goal. Materials and Methods: Cell counting kit-8 (CCK8) assays, wound healing analyses, Transwell assays, in vitro tumor xenografts, and flow cytometry were used to detect the proliferation, migration, invasion, and apoptosis of multidrug resistant A549/DDP and PC9/ DDP cells, respectively. Western blot was performed to detect protein levels of cleaved caspase-3, CHOP, and GRP78. Results: Delicaflavone inhibited DDP resistance of lung cancer cells and decreased proliferation in a dose-and time-dependent manner. It also decreased migration and invasion and enhanced apoptosis. Western blots showed that delicaflavone overcame DDP resistance by increasing the expression of GRP78 and CHOP and the apoptosis-related protein cleaved caspase-3. Conclusion: Delicaflavone can reverse DDP resistance in A549/DDP and PC9/DDP cells by inhibiting cell proliferation and migration and enhancing apoptosis and cleaved caspase-3 levels by increasing the expression of CHOP and GRP78 protein via the endoplasmic reticular stress pathway. It could be a useful therapeutic adjunct to treat DDP-resistant lung cancer.

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“…Despite the decline in the rate of non-small cell lung cancer (NSCLC) in recent years, it remains the leading cause of cancer mortality worldwide, 1.8 million people are diagnosed with lung cancer, and 1.6 million individuals died as a result of the disease in 2017 worldwide (1). Accurate diagnosis and precise prognostic predictions are critical for targeted treatment and prolonging the overall survival of patients with NSCLC (2).…”

Section: Introductionmentioning

confidence: 99%

Ring finger protein 180 is associated with biological behavior and prognosis in patients with non‑small cell lung cancer

Liu

Yang

et al. 2020

Oncol Lett

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There are few studies on the role of ring finger protein (RNF)180 in non-small cell lung cancer (NSCLC). The present study investigated the expression of RNF180 in NSCLC and its associations with the clinical factors and prognosis of NSCLC. The mRNA and protein expression levels of RNF180 were detected via reverse transcription-quantitative PCR and western blotting. Methylation-specific PCR (MSP) analysis was utilized to detect the methylation of RNF180. RNF180 expression levels were analyzed via immunohistochemistry. The protein and mRNA expression levels of RNF180 were lower in NSCLC cell lines compared with in the non-tumor cell line. Immunohistochemistry revealed that 64 patients that were negative for RNF180, while MSP detection analysis demonstrated that 60 patients exhibited RNF180 promoter methylation. The methylation status of RNF180 was significantly associated with RNF180 expression level. Among all factors evaluated, logistic regression analysis indicated that only T stage was significantly associated with RNF180 expression. Cox multivariate analysis demonstrated that RNF180 expression was an independent predictor of overall survival in patients with NSCLC. Methylation in the promoter of RNF180 was shown to reduce its expression levels. In summary, low RNF180 expression levels were associated with poor biological behaviors, thus RNF180 expression level may be used as a clinical marker to predict the prognosis of patients with NSCLC. Materials and methods Cell culture. NSCLC cell lines (A549 and HCC827) and a non-tumor cell line (MRC-5) were obtained from The Cell Bank of Type Culture Collection of Chinese Academy of Sciences. Cells were cultured in RPMI-1640 medium (Gibco; Thermo Fisher Scientific, Inc.) supplemented with 10% FBS (HyClone; Cytiva) and 100 U/ml penicillin-streptomycin (HyClone; Cytiva) at 37˚C under a humidified atmosphere of 5% CO 2 .

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The descriptive epidemiology of lung cancer and tobacco control: a global overview 2018

Abstract: Miranda-Filho A, Piñeros M, Bray F. Epidemiología descriptiva del cáncer de pulmón y control de tabaco en 2018: una visión global.

Cited by 36 publications

References 10 publications

Downregulated microRNA‑140‑5p expression regulates apoptosis, migration and invasion of lung cancer cells by targeting zinc finger protein 800

Downregulated microRNA‑140‑5p expression regulates apoptosis, migration and invasion of lung cancer cells by targeting zinc finger protein 800

<p>Delicaflavone Reverses Cisplatin Resistance via Endoplasmic Reticulum Stress Signaling Pathway in Non-Small Cell Lung Cancer Cells</p>

Ring finger protein 180 is associated with biological behavior and prognosis in patients with non‑small cell lung cancer

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