1979
DOI: 10.1111/j.1365-2133.1979.tb08070.x
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The dermatopathology of Cowden's syndrome*

Abstract: During the past 2 years we have studied eighty-nine biopsy specimens from nineteen patients with Cowden's syndrome. Among fifty-three facial lesions, twenty-nine were trichilemmomas. Twenty-three of the others were consistent with trichilemmoma, showed a non-specific benign verrucous acanthoma, or were not diagnostic; one was a blue naevus. All fourteen oral mucosal biopsy specimens were benign fibromas. Nineteen of twenty-two biopsy specimens from the hands and feet showed the pattern of benign keratosis. Mul… Show more

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Cited by 176 publications
(98 citation statements)
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“…2H) (20,21). Whereas no benign tumors were observed in hair follicles or tongue of Pten mutant mice, these tissues were mildly hyperplastic in the absence of Pten (Fig.…”
Section: Deletion Of Pten In the Skinmentioning
confidence: 99%
“…2H) (20,21). Whereas no benign tumors were observed in hair follicles or tongue of Pten mutant mice, these tissues were mildly hyperplastic in the absence of Pten (Fig.…”
Section: Deletion Of Pten In the Skinmentioning
confidence: 99%
“…6 Other typical features include oral and facial papules, goitre and benign hamartomas of the thyroid and digestive tract. 7 A large number of CD patients (ie more than 80%) develops macrocephaly, 2 which is a true megalencephaly, but only a fraction of the patients develop Lhermitte-Duclos disease (LDD). This rare condition is believed to be a hamartomatous outgrowth of the cerebellum, characterised by hypertrophic ganglion cells.…”
Section: Introductionmentioning
confidence: 99%
“…Any two major criteria; or one major and two minor criteria; or 3 minor criteria are sufficient for an operational diagnosis in a family where one individual meets the clinical diagnostic criteria or has a PTEN mutation benign skin adnexal tumours possess a smooth or warty surface and range from 2 mm to more than 10 mm [4]. Acral keratosis presents as 2-3 mm skin coloured or tan papules on the palms and soles (and can resemble common warts) [5,6].…”
Section: Introductionmentioning
confidence: 99%
“…Multiple papillomatous papules arise on the oral mucosa most commonly on the ventral tongue, lips, buccal mucosa, gingivae and palate [5,7]. These flesh-coloured firm papules are 1-7 mm in diameter and their multiplicity can produce a cobblestone-like appearance [8,9].…”
Section: Introductionmentioning
confidence: 99%