The depth of molecular recognition: voltage-sensitive blockage of synthetic multifunctional pores with refined architecture

Baudry, Yoann Cyril; Pasini, Dario; Nishihara, Masamichi; Sakai, Naomi; Matile, Stefan

doi:10.1039/b509610c

Cited by 24 publications

(35 citation statements)

References 28 publications

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“…60 The voltage dependence of blockage described in the Woodhull equation 6 identifies the existence of inclusion complexes. 50 log…”

Section: Ligand Gating and Blockagementioning

confidence: 99%

Transport Experiments in Membranes

Matile¹,

Sakai²,

Hennig³

2012

Supramolecular Chemistry

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In this contribution, we describe methods to characterize the activity of synthetic transport systems in translocating molecules across otherwise impermeable membranes. The first two sections introduce methods with bulk membranes (U-tube experiments) and planar or "black" lipid membranes (BLMs), and close with a more comprehensive overview of methods involving liposomes, in particular large unilamellar vesicles (LUVs). The fourth section focuses on the application of these methods to the elucidation of the functional characteristics of synthetic transport systems. This includes sensitivity toward membrane composition, membrane potential, pH, anions, cations, molecular recognition (sensing), molecular transformation (catalysis) or light (photosynthesis).

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“…60 The voltage dependence of blockage described in the Woodhull equation 6 identifies the existence of inclusion complexes. 50 log…”

Section: Ligand Gating and Blockagementioning

confidence: 99%

Transport Experiments in Membranes

Matile¹,

Sakai²,

Hennig³

2012

Supramolecular Chemistry

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“…13,15 The same was true for the deletion of the cation selectivity of pore 6 with Mg 2þ . 13,15 Similarly satisfactory agreement has been found for the determination of voltage dependence of ion channel formation (i.e., gating charges) 10,36 and blockage (i.e., electric distances) 54 in BLMs and LUVs.…”

Section: Correlation Of Results On Ion Selectivity From Blms and Luvsmentioning

confidence: 61%

The determination of the ion selectivity of synthetic ion channels and pores in vesicles

Sakai

Matile

2006

J of Physical Organic Chem

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Organic chemists entering the field of synthetic ion channels and pores are often restricted to the characterization of their creation by fluorescence kinetics in vesicles and do not have access to conductance experiments in planar bilayer membranes. This limitation excludes the application of methods to evaluate key characteristics such as ion selectivity or voltage gating that are routine in the membrane biophysics community.

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“…113 Even in the limited suprastructural space of p-oligophenyl -barrels, internal NDI -clamps are just one out of many possibilities to create refined active sites. 114,115 As far as functional sophistication and diversity are concerned, the discussed examples for ion channels, sensors, and photosystems hint at enormous potential available in both directions. With regard to sophistication, the advanced situation with channels and pores invites to tackle specific challenges such as control over partitioning 70 or the detection of catalysis within pores on the single molecule level.…”

Section: Resultsmentioning

confidence: 99%

Synthetic Multifunctional Nanoarchitecture in Lipid Bilayers: Ion Channels, Sensors, and Photosystems

Bhosale

Bollot

et al. 2007

Bulletin of the Chemical Society of Japan

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The creation of functional materials such as ion channels, porous sensors, or smart photosystems depends critically on our ability to assemble sophisticated, error-free and self-repairing nanoarchitecture in a predictable manner. To address these challenging topics, we often used lipid bilayer membranes as compartmentalizing platform and have introduced rigid-rod molecules as privileged scaffolds that bypass all folding problems because they do not fold. This approach provides access to motifs such as rigid-rod barrels, helices, stacks, slides, and wires that can act as smart, stimuli-responsive photosystems, pores, ion channels, hosts, sensors, and catalysts. The selected examples focus on naphthalenediimides (NDIs), a compact, organizable, colorizable, and functionalizable n-semiconductor. This versatile module is used in rigid-rod molecules to mediate transmembrane anion transport by anion-interactions, as sticky -clamp within pore sensors to catch otherwise elusive analytes by aromatic electron donor-acceptor interactions, or in blue, transmembrane -stack architecture to collect and convert photonic energy. These specific examples with multifunctional NDI nanoarchitecture are of help to outline, on the one hand, possibilities to contribute to advanced functional materials such as multianalyte sensors or solar cells and, on the other hand, to keep on wondering about an enormous structural and functional space waiting to be explored.In biology, highest sophistication on both the structural and functional level is accomplished with membrane proteins. Ion channels and pores, for instance, function as stimuli-responsive multianalyte sensors that assure perception of and communication with the outside world.

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The depth of molecular recognition: voltage-sensitive blockage of synthetic multifunctional pores with refined architecture

Cited by 24 publications

References 28 publications

Transport Experiments in Membranes

Transport Experiments in Membranes

The determination of the ion selectivity of synthetic ion channels and pores in vesicles

Synthetic Multifunctional Nanoarchitecture in Lipid Bilayers: Ion Channels, Sensors, and Photosystems

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