The “depressive” face of osteoporosis and the “osteoporotic” face of depression

Aloumanis, Kyriakos; Mavroudis, Kostantinos

doi:10.1007/bf03401301

Cited by 27 publications

(18 citation statements)

References 92 publications

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“…Associations of depression with bronchitis and migraines have appeared in additional studies (Clancy et al, 2013;Patten-Scott et al, 2008). Aloumanis and Mavroudis (2013) showed that depression was associated with a decrease in bone density, increasing the risk for fractures. Low bone density was common in postmenopausal women and depression was a risk factor for steatosis.…”

Section: Somatization and Painmentioning

confidence: 99%

“…In periods of depression there is hyperstimulation of the HPA axis, which increases adrenal hormones and serum cortisol of the endocrine system in response to stimuli (Aloumanis & Mavroudis, 2013;Farmer et al, 2008;Johnson & Grippo, 2006;Meyer et al, 2004;Romero et al, 2004;Smith-Patrick & Blumenthal, 2011;Wolkowitz et al, 2011). Also, the cytokines of the immune system stimulate the release of neurotransmitters and hormones, altering the function of the cardiovascular system.…”

Section: Alteration Of the Hypothalamic-pituitary-adrenal Axismentioning

confidence: 99%

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Depression as a Risk Factor of Organic Diseases: An International Integrative Review

Bica

Castelló

Toussaint

et al. 2017

J of Nursing Scholarship

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A good patient-provider relationship can help to promote decreased acute or chronic stressors, increased family and social support, decreased loneliness, modification of unhealthy lifestyles such as smoking, obesity, physical inactivity, alcohol, control of CRP, and antidepressant medication. Nurses are well placed to help prevent physical diseases through detection and referral of patients who are depressed or undiagnosed and not receiving adequate mental health treatment.

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Section: Somatization and Painmentioning

confidence: 99%

Section: Alteration Of the Hypothalamic-pituitary-adrenal Axismentioning

confidence: 99%

Depression as a Risk Factor of Organic Diseases: An International Integrative Review

Bica

Castelló

Toussaint

et al. 2017

J of Nursing Scholarship

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“…Depression adversely affects bone density and increases fracture risk . Some studies have shown that the use of SSRI was associated with a statistically significant increase in the risk of osteoporotic fractures .…”

Section: Risk Of Antidepressant Drugs In the Elderlymentioning

confidence: 99%

“…Depression adversely affects bone density and increases fracture risk. 66 Some studies have shown that the use of SSRI was associated with a statistically significant increase in the risk of osteoporotic fractures. 67 The risk with SSRI, probably related to the degree of inhibition of serotonin re-uptake in osteoclasts, osteoblasts, and osteocytes, 68,69 can be higher than with TCA or other antidepressants.…”

Section: Risk Of Osteoporotic Fracturesmentioning

confidence: 99%

Risk–benefit analysis of antidepressant drug treatment in the elderly

et al. 2014

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Depression in the elderly is a significant health issue that has the potential to seriously affect physical and emotional well-being. Therefore, the treatment of geriatric depression is necessary. Antidepressant treatment in older depressed patients is efficacious, but differences in the effectiveness of different classes of antidepressants have not been demonstrated. However, differences in tolerability profile are most recognizable in the elderly. With ageing, a series of changes occur in the elderly that modify both the pharmacokinetics and pharmacodynamics of antidepressants and may influence the efficacy, tolerability and safety of treatment in the elderly. Comorbidities require the use of other drugs, which increases the possibility of drug-drug interactions. Given these aspects, individualized therapy for each elderly patient is needed to achieve acceptable risk-benefit ratio. Effective treatment of depression in the elderly, which may require combined pharmacological with psychosocial treatment, can decrease both morbidity and mortality; it also may lead to reduced demands on family members and on health-care and social services.

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“…11 The rising global economic burden related to the direct and indirect costs of medical care and rehabilitation of individuals with osteoporotic fractures is concerning 1213 Both clinically diagnosed unipolar depression and depressive symptoms have been shown to be associated with deficits in bone mineral density (BMD), bone loss over time and increased fracture risk in men and women 914 15 Furthermore, antidepressants, in particular, selective serotonin reuptake inhibitors used in treatment of depression, have also been shown to be noxious to bone 16.…”

Section: Introductionmentioning

confidence: 99%

Association between bipolar spectrum disorder and bone health: a meta-analysis and systematic review protocol

et al. 2017

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IntroductionBipolar spectrum disorder is a chronic, episodic illness, associated with significant personal, social and economic burden. It is estimated to affect ∼2.4% of the population worldwide and is commonly associated with psychological and/or physiological comorbidities. Osteoporosis is one such comorbidity, a disease of bone that is asymptomatic until a fracture occurs. This systematic review attempts to capture, collate, assess and discuss the literature investigating the association between bipolar spectrum disorder and bone health.Methods and analysisWe aim to identify articles that investigate the association between bipolar spectrum disorder and bone health in adults by systematically searching the MEDLINE, PubMed, OVID and CINAHL databases. Two independent reviewers will determine eligibility of studies according to predetermined criteria, and methodological quality will be assessed using a previously published scoring system. A meta-analysis will be conducted, and statistical methods will be used to identify and control for heterogeneity, if possible. If numerical syntheses are prevented due to statistical heterogeneity, a best evidence synthesis will be conducted to assess the level of evidence for associations between bipolar spectrum disorder and bone health.Ethics and disseminationEthical permission will not be required for this systematic review since only published data will be used. This protocol will be registered with PROSPERO. Findings of the review will be published in a peer-reviewed scientific journal, and will be presented to clinical and population health audiences at national and international conferences.

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The “depressive” face of osteoporosis and the “osteoporotic” face of depression

Cited by 27 publications

References 92 publications

Depression as a Risk Factor of Organic Diseases: An International Integrative Review

Depression as a Risk Factor of Organic Diseases: An International Integrative Review

Risk–benefit analysis of antidepressant drug treatment in the elderly

Association between bipolar spectrum disorder and bone health: a meta-analysis and systematic review protocol

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