The dependence of the incorporation of methamphetamine into rat hair on dose, frequency of administration and hair pigmentation

Han, Eunyoung; Park, Yonghoon; Kim, Eun‐Mi; Lee, Sooyeun; Choi, Hwakyung; Chung, Heesun; Song, Joon Myong

doi:10.1016/j.jchromb.2010.08.040

Cited by 16 publications

(8 citation statements)

References 28 publications

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“…A positive linear relationship between dose and hair concentration has been identified for cocaine and medicinal drug use (200) with segmented analysis of hair used to evaluate changes in dose over time (201,202). In relation to use of methamphetamine, a positive dose-response relationship has been demonstrated with rat hair (203), in drug users (204) and in a controlled study (199).…”

Section: Dose Responsementioning

confidence: 92%

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Wright

Edwards

Walker

2016

Reviews on Environmental Health

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AbstractThe clandestine manufacture of methamphetamine in residential homes may represent significant hazards and exposures not only to those involved in the manufacture of the drugs but also to others living in the home (including children), neighbours and first responders to the premises. These hazards are associated with the nature and improper storage and use of precursor chemicals, intermediate chemicals and wastes, gases and methamphetamine residues generated during manufacture and the drugs themselves. Many of these compounds are persistent and result in exposures inside a home not only during manufacture but after the laboratory has been seized or removed. Hence new occupants of buildings formerly used to manufacture methamphetamine may be unknowingly exposed to these hazards. Children are most susceptible to these hazards and evidence is available in the literature to indicate that these exposures may result in immediate and long-term adverse health effects. The assessment of exposure within the home can be undertaken by measuring contaminant levels or collecting appropriate biological data from individuals exposed. To gain a better understanding of the available data and key issues associated with these approaches to the characterisation of exposure, a review of the published literature has been undertaken.

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Section: Dose Responsementioning

confidence: 92%

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Wright

Edwards

Walker

2016

Reviews on Environmental Health

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“…Hair collection procedures, hair analysis, and GC/MS conditions have been previously described [13][14][15].…”

Section: Methodsmentioning

confidence: 99%

“…The detailed sample preparation method has been previously described [13][14][15]. The hair segments were prepared in two segmenting patterns that measured 1 cm and 3 cm each from hair roots in order to correspond to individual month and the recent three months.…”

Section: Hair Collection and Hair Analysismentioning

confidence: 99%

Relationship between methamphetamine use history and segmental hair analysis findings of MA users

Han¹,

Lee²,

In³

et al. 2015

Forensic Science International

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“…Ratlarda yapılan diğer bir çalışmada, kıldaki metamfetamin ve amfetamin konsantrasyonunun doz ve uygulama sıklığıyla doğru orantılı olduğu bildirilmiştir. 25 Aynı çalışmada, pigmente kılda beyaz kıla göre metamfetamin ve amfetamin konsantrasyonu 2-10 kat daha fazla bulunmuştur. 25 Yeni psikoaktif maddelerden olan feniletilaminden türetilmiş 25B-NBOMe, 25C-NBOMe ve 25I-NBOMe uygulanan ratlarda; siyah kılda beyaz kıla göre daha fazla konsantrasyonda madde belirlenmiş, ayrıca siyah kılda doz bağımlı ilaç konsantrasyonunda artış saptanmıştır.…”

Section: Kilin Pi̇gmentasyonuunclassified

“…25 Aynı çalışmada, pigmente kılda beyaz kıla göre metamfetamin ve amfetamin konsantrasyonu 2-10 kat daha fazla bulunmuştur. 25 Yeni psikoaktif maddelerden olan feniletilaminden türetilmiş 25B-NBOMe, 25C-NBOMe ve 25I-NBOMe uygulanan ratlarda; siyah kılda beyaz kıla göre daha fazla konsantrasyonda madde belirlenmiş, ayrıca siyah kılda doz bağımlı ilaç konsantrasyonunda artış saptanmıştır. 26 Ratlara sentetik kannabinoid JWH-073 verilerek yapılan bir çalışmada, pigmente ve pigmente olmayan kıllarda yapılan analizde, madde konsantrasyonu yönünden kıllar arasında anlamlı fark bulunmamıştır.…”

Section: Kilin Pi̇gmentasyonuunclassified

Incorporation of Drug and Substances in Hair

Mutlu¹,

Aşıcıoğlu²

2018

Turkiye Klinikleri J Foren Sci Leg Med

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aç, homojen bir yapıya sahip gibi görünse de aslında oldukça karmaşık olan biyolojisi kısmen anlaşılmıştır.1 Memelilerde saç; protein (%65-95), su (%15-35), lipit (%1-9) ve minerallerden (<%1) oluşan deri eklerinden biridir. Saç şaftında korteksi çevreleyen bir kütikül bulunduğu gibi, bazı saç tiplerinde santral medullayı çevreleyen ilave bir kütikülde bulunmaktadır.2 Saç apokrin, sebase ve ter bezleriyle yakın ilişkide olan cildin A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Saç; ilaç; birikim; kötüye kullanım A AB BS S T TR RA AC CT T In recent years hair has become a fundamental biological specimen, alternative to the usual samples blood and urine, for drug testing in the fields of forensic toxicology, clinical toxicology and clinical chemistry. Analytical results of drugs of abuse in hair provide useful information on chronic drug use. They are valuable to presume the history and severity of individual drug abuse and to provide supplementary information on drug use to facilitate interpretation of urine drug analysis. Hair testing has larger detection window. The sample collection is non-invasive. Another advantage of hair samples is that it can be stored at room temperature and do not need to be analyzed quickly after they are collected. Hair analysis is also used for detection of gestational drug exposure, doping control and detection of alcohol abuse. It has been reported that drugs are incorporated into hair by binding to such intracellular components as melanins, lipids, and proteins. It has been proposed that drugs and substances can enter into hair during at least 3 stages: from the blood during hair formation, from sweat and sebum, and from external environment. The aim of this review is to document and discuss the mechanisms of drug or substance accumulation in hair and its influencing factors, application of hair analysis.

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The dependence of the incorporation of methamphetamine into rat hair on dose, frequency of administration and hair pigmentation

Cited by 16 publications

References 28 publications

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Relationship between methamphetamine use history and segmental hair analysis findings of MA users

Incorporation of Drug and Substances in Hair

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