The Dependence of Exocrine Pancreatic Secretion on Insulin in Sheep

Pierzynowski, Stefan; Barej, W.

doi:10.1113/expphysiol.1984.sp002793

Cited by 25 publications

(18 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the pancreas, insulin potentiates acetylcholine-evoked amylase release (Singh, 1985), cholecystokinin-stimulated secretion (Saito et al, 1980), and the response to pancreozymin (Kanno and Saito, 1976). Finally, Pierszynowski and Barej (1984) reported that pancreatic secretion in sheep is insulin-dependent. Interestingly, insulin by itself had no secretary effects, suggesting that it may play an important role in maintaining normal exocrine cell function through permissive effects on agonist-response coupling.…”

Section: Resultsmentioning

confidence: 94%

Parotid Gland Function in Streptozotocin-diabetic Rats

Anderson

1987

J Dent Res

View full text Add to dashboard Cite

The in vivo response of parotid glands to adrenergic, cholinergic, and peptidergic agonists was studied in control, streptozotocin- (one month's duration), and insulin-treated (three hr) diabetic rats. Neither diabetes nor insulin had an effect on the response to physalaemin. In contrast, physalaemin threshold-dose was lower and maximal response greater in control rats placed on a bulk diet. As previously described, diabetes resulted in nonparallel changes in parotid protein composition, including a production in amylase and an increase in peroxidase concentrations (mg/mg protein). In contrast to the results observed with physalaemin, response to methacholine was significantly reduced in diabetic animals, and could be restored to control levels by insulin. Placement of animals on a bulk-diet, however, had no effect on threshold response to methacholine. Finally, response threshold for epinephrine was unaffected by diabetes, insulin, or bulk diet. Thus, insulin appears, directly and specifically, to alter the response of parotid acinar cells to cholinergic stimulation.

show abstract

Section: Resultsmentioning

confidence: 94%

Parotid Gland Function in Streptozotocin-diabetic Rats

Anderson

1987

J Dent Res

View full text Add to dashboard Cite

show abstract

“…(), who reported that regulation of abomasal infusion of starch and/or casein to α‐amylase secretion in steers was not insulin dependent. In addition, in diabetic sheep, insulin administration did not result in α‐amylase secretion returning to normal level (Pierzynowski and Barej, ). These results suggested that the effect of leucine on α‐amylase secretion was not dependent on the change in blood insulin in ruminants.…”

Section: Discussionmentioning

confidence: 99%

Leucine markedly regulates pancreatic exocrine secretion in goats

Liu

Yao

et al. 2013

Animal Physiology Nutrition

View full text Add to dashboard Cite

Four goats (30.1 ± 1.3 kg) with common bile duct re-entrant catheter and duodenal catheter were used to evaluate the effects of duodenal leucine infusion on pancreatic exocrine secretion and plasma parameters with two 4 × 4 Latin square design experiments. In the long-term infusion experiment, goats were fed twice daily [700 g/day, dry matter (DM) basis] at 8:00 and 18:00 hours and were duodenally infused with 0, 3, 6, 9 g/day leucine for 14 days. Pancreatic juice and jugular blood samples were collected over 1-h intervals for 6 h daily from d 11 to 14 days to encompass a 24-h day. In the short-term experiment, goats were infused leucine for 10 h continuously at the same infusion rate with Experiment 1 after feed deprivation for 24 h repeated every 10 days. Pancreatic juice and blood samples were collected at 0, 1, 2, 4, 6, 8 and 10 h of infusion. The results showed that the long-term leucine infusion did not affect pancreatic juice secretion, protein output, trypsin and lipase secretion and plasma insulin concentration, but linearly increased α-amylase secretion. No changes in pancreatic protein and lipase secretion were observed in the short-term infusion. Pancreatic juice and α-amylase secretion responded quadratically, with the greatest values observed in the 3 and 6 g/day leucine respectively. Trypsin secretion linearly decreased, while plasma insulin concentration increased linearly with increased leucine infusion. The results demonstrated that duodenal leucine infusion dose and time dependently regulated pancreatic enzyme secretion not associated with the change in plasma insulin concentration.

show abstract

“…Another possible reason for the greater pancreatic α‐amylase activity in our milk‐fed pre‐ruminant kids is that it was stimulated by the higher insulin levels, as occurs in rats, where plasma insulin level increases just before weaning, enhancing pancreatic functional development (Kinouchi et al., 1998, 2000). It was suggested some time ago that insulin plays an important role in the regulation of pancreatic juice production in ruminants (Pierzynowski and Barej, 1984). The present study confirms that plasma insulin level and pancreatic α ‐amylase activity are strongly correlated, around weaning.…”

Section: Discussionmentioning

confidence: 99%

Ghrelin, insulin and pancreatic activity in the peri-weaning period of goat kids

Magistrelli

Pinotti

Rapetti

et al. 2011

Journal of Animal Physiology and Animal Nutrition

View full text Add to dashboard Cite

Two groups of 3-day-old Saanen goat kids (MILK and WMIX) were studied in order to investigate the effect of weaning on plasma ghrelin and insulin and on pancreatic activity. MILK kids received goat milk to age 50 days; WMIX kids were initially fed milk but started weaning at 30 days and were completely weaned by 48 days. Dry matter intake and body weights were recorded, and plasma samples were analysed for metabolites, ghrelin, insulin, leptin and α-amylase. At 50 days, all the animals were slaughtered, pancreas samples were analysed for α-amylase, zymogen, DNA and ribosomal capacity (RNA/zymogen). Seven days after the beginning of the weaning program, dry matter intake in the WMIX group began to decrease in relation to the MILK group. Nonetheless, body weight did not differ throughout the study period. Weaning significantly decreased plasma levels of glucose, amino acids, urea and insulin, but increased creatinine and ghrelin. In weaning kids ghrelin secretion may help minimize the negative consequences of the new diet on dry matter intake. Pancreatic zymogen and ribosomal capacity did not differ between the groups, whereas pancreatic amylase activity was over three times higher in MILK than WMIX kids even though the former had no dietary starch. This finding could be a consequence of lower pancreatic secretion of amylase in the MILK group due to the lack of dietary starch, resulting in pancreatic accumulation, but could also be due to higher plasma insulin in the MILK group, suggesting a role for insulin in the functional development of the pancreas in weaning goats.

show abstract

The Dependence of Exocrine Pancreatic Secretion on Insulin in Sheep

Cited by 25 publications

References 8 publications

Parotid Gland Function in Streptozotocin-diabetic Rats

Parotid Gland Function in Streptozotocin-diabetic Rats

Leucine markedly regulates pancreatic exocrine secretion in goats

Ghrelin, insulin and pancreatic activity in the peri-weaning period of goat kids

Contact Info

Product

Resources

About