The denture microbiome in health and disease: an exploration of a unique community

Redfern, James; Tosheva, Lubomira; Malic, Sladjana; Butcher, Mark C.; Ramage, Gordon

doi:10.1111/lam.13751

Cited by 17 publications

(26 citation statements)

References 128 publications

(219 reference statements)

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“…As dentures are not sterile and are used at the body‐external environment interface, it is possible to be colonized by microorganisms. Once placed in the patient's mouth, the denture surface becomes coated with an 'acquired pellicle' of salivary glycoproteins (including salivary amylase, albumin, mucin, and lysozyme) and immunoglobulins [ 19 ]. The prosthesis surfaces represent the interface being colonized by oral biofilm a few hours after placement [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Microbial Adhesion to Different Thermoplastic Denture Base Materials in Kennedy Class I Partially Edentulous Patients

Sakr,

AbdulSalam,

Fayad

et al. 2024

Cureus

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Introduction Since the polished and fitting surface of the denture base may promote the colonization of microorganisms, it is essential to know how the different types of denture bases prevent or encourage the adhesion of microorganisms. This study aimed to compare the microbial adhesion to the polished and fitting surfaces of thermoplastic nylon, thermoplastic acetal, and thermoplastic acrylic denture bases in Kennedy Class Ⅰ, partially edentulous patients. Materials and methods Thirteen patients were included in the study. The group consisted of eight males (61.54%) and five females (38.46%), with an age range of 41-50 years (mean age 46.1 years). Three types (groups) of removable partial dentures will be made for each patient using different thermoplastic denture base materials: thermoplastic nylon; thermoplastic acetal; and thermoplastic acrylic. The polished and fitting surfaces of the denture bases were swabbed after a one-month follow-up period. Microbial adhesion was evaluated by counting the microorganisms' colony-forming units (CFU) in the collected specimens. The data were collected and statistically analyzed. Results The study revealed no statistically significant difference in microbial adhesion to both polished and fitting surfaces between all types of studied thermoplastic denture base materials. However, the results showed that for the polished surface, the microbial adhesion median of thermoplastic acrylic denture base (40.5 CC x 10 2 /ml) was higher than that of thermoplastic acetal (29.0 CC x 10 2 /ml) and thermoplastic nylon (16.0 CC x 10 2 /ml). Regarding the fitting surface, the microbial adhesion median of thermoplastic acrylic (51.0 CC x 10 2 /ml) is higher than that of thermoplastic acetal (41.0 CC x 10 2 /ml) and thermoplastic nylon (23.0 CC x 10 2 /ml). Conclusion The thermoplastic nylon denture base materials showed less microbial adhesion among the studied thermoplastic materials, so it may be recommended to be used as a denture base material for individuals at high risk of denture stomatitis.

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Section: Discussionmentioning

confidence: 99%

Microbial Adhesion to Different Thermoplastic Denture Base Materials in Kennedy Class I Partially Edentulous Patients

Sakr,

AbdulSalam,

Fayad

et al. 2024

Cureus

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“…On a more positive note over recent years there has been a steady decline in the proportion of the population who have no natural teeth. Nevertheless, this will not immediately translate into a reduction in denture wearing [ 32 ]. A recent survey of adults attending dental practices in the UK reported that 13.7% had partial dentures; with a higher prevalence with increasing age so that more than 40% of those aged 75 or over were partial denture wearers [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…A recent survey of adults attending dental practices in the UK reported that 13.7% had partial dentures; with a higher prevalence with increasing age so that more than 40% of those aged 75 or over were partial denture wearers [ 33 ]. Our understanding of the long-term consequences of complete and partial denture use is limited, particularly in relation any possible associations with systemic diseases or conditions [ 32 , 34 ]. If, as suggested by the results of the present study, denture wearing in individuals who retain at least some of their natural teeth, could increase the risk of poorer lung function, then it will be important to assess the implications at a public health level.…”

Section: Discussionmentioning

confidence: 99%

“…The association between denture wear and airflow limitation reported in this study does not provide information on possible mechanisms. Dentures support the growth of complex polymicrobial biofilms of bacteria and yeasts known as denture plaque [ 32 , 35 ]. The majority (65%) of denture plaque biofilms are colonised by known respiratory pathogens, including S .…”

Section: Discussionmentioning

confidence: 99%

“…Candida spp. are secondary colonisers of denture plaque [ 32 ] and the most commonly identified species Candida albicans can facilitate the growth of respiratory pathogens [ 19 ] and increase the frequency of COPD exacerbations [ 37 ]. Further investigations of possible mechanistic links between alterations in both the oral and lung microbiomes, and mycobiomes, related to denture wearing and possible involvement in the pathogenesis of lung diseases would be helpful.…”

Section: Discussionmentioning

confidence: 99%

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The association of denture wearing with reduced lung function and increased airflow limitation in 58–72 year old men

et al. 2023

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Objective To investigate the association between denture wearing and airflow limitation in men in Northern Ireland enrolled in the Prospective Epidemiological Study of Myocardial Infarction (PRIME) study. Methods A case-control design was used to study partially dentate men. Cases were men aged 58–72 years who were confirmed as denture wearers. Controls were never denture wearers who were matched by age (± 1 month) and smoking habit to the cases. The men had a periodontal assessment and completed a questionnaire detailing their medical history, dental history and behaviours, social circumstances, demographic background and tobacco use. Physical examination and spirometry measurements of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were also undertaken. Spirometry data for edentulous men who wore complete dentures were compared with that recorded for the partially dentate men studied. Results There were 353 cases who were partially dentate and were confirmed denture wearers. They were matched for age and smoking habit to never denture wearer controls. The cases had an FEV1 that was on average 140 ml lower than the controls, p = 0.0013 and a 4% reduction in percent predicted FEV1, p = 0.0022. Application of the GOLD criteria indicated that 61 (17.3%) of the cases had moderate to severe airflow limitation compared with 33 (9.3%) of controls, p = 0.0051. Fully adjusted multivariable analysis showed that partially dentate men who were denture wearers were significantly more likely (p = 0.01) to have moderate to severe airflow reduction with an adjusted odds ratio (OR) of 2.37 (95% confidence intervals 1.23–4.55). In the 153 edentulous men studied moderate to severe airflow limitation was recorded in 44 (28.4%), which was significantly higher than in the partially dentate denture wearers (p = 0.017), and the men who had never worn a denture (p<0.0001). Conclusion Denture wearing was associated with an increased risk of moderate to severe airflow limitation in the cohort of middle-aged Western European men studied.

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The association between poor oral health and risk of breast cancer in the UK Biobank

Sang

et al. 2023

Cancer Causes Control

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The denture microbiome in health and disease: an exploration of a unique community

Abstract: Dentures are becoming increasingly common. Since colonisation (and subsequence biofilm formation) by some microorganisms to dentures can significantly impact, the study of denture microbiology has long been of interest to researchers.

Cited by 17 publications

References 128 publications

Microbial Adhesion to Different Thermoplastic Denture Base Materials in Kennedy Class I Partially Edentulous Patients

Microbial Adhesion to Different Thermoplastic Denture Base Materials in Kennedy Class I Partially Edentulous Patients

The association of denture wearing with reduced lung function and increased airflow limitation in 58–72 year old men

The association between poor oral health and risk of breast cancer in the UK Biobank

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