The dental perspective on osteogenesis imperfecta in a Danish adult population

Abstract

BackgroundTo report on dental characteristics and treatment load in Danish adult patients with osteogenesis imperfecta (OI).MethodsOral examination of 73 patients with OI was performed and OI type I, III, and IV were represented by 75.3%, 8.2%, and 16.4%, respectively. Patients were diagnosed as having dentinogenesis imperfecta (DI) if they had clinical and radiological signs of DI. In the data analysis, mild OI (type I) was compared to moderate-severe OI (type III and IV).ResultsDiscoloration of teeth was prevalent in patients with moderate-severe compared to mild OI (83.3% vs. 5.5%, p < 0.001). Cervical constriction and pulpal obliteration were frequent findings in patients with moderate-severe OI (61.1% and 88.9%, respectively), whereas pulp stones and taurodontism were diagnosed in patients with mild OI only (29.1% and 9.1%, respectively). DI was found in 24.7% of OI patients and considerably more frequent in patients with moderate-severe (94.4%) compared to mild OI (1.8%) (p < 0.001). The number of teeth with artificial crowns was significantly higher in patients with moderate-severe OI than in patients with mild OI (median 1.5, range 0–23 vs. median 0, range 0–14) (p < 0.001). The number of teeth with fillings in patients with mild OI was significantly higher than in patients with moderate-severe OI (mean 9.7, SD 5.1, median 9.0, range 1–21 vs. mean 5.0, SD 4.4, median 4.0, range 0–16) (p < 0.001).ConclusionsOne fourth of patients with OI had DI, and the vast majority of them had moderate-severe OI. Whereas discoloration of teeth, cervical constriction and pulp obliteration were frequent findings in patients with moderate-severe OI, pulp stones and taurodontism were found in patients with mild OI only. In patients with moderate-severe OI, the dental treatment load was dominated by prosthetic treatment, whereas restorative treatment with fillings was more prevalent in patients with mild OI.

Oral health‐related quality of life in X‐linked hypophosphataemia and osteogenesis imperfecta

“…The dental parts of the studies were performed at Section of Pediatric Dentistry, Department of Dentistry and Oral Health, Aarhus University, Denmark. Intraoral clinical photographs and panoramic radiographs were obtained as previously described 8,17 . The total number of teeth in the oral cavity was counted.…”

Reduced mesiodistal tooth dimension in individuals with osteogenesis imperfecta: a cross-sectional study

“…The Danish individuals with OI comprised 57 participants. Sixteen individuals who originally participated in the dental part of the study by Hald and colleagues [18,19] were excluded in the present study owing to missing digital 3 Dmodels. The reasons for absent models were various logistic challenges.…”

“…Keeping in mind that heterogeneity appears for OI, the representation of the different OI types might be of importance for the results, since individuals with a diagnosis of OI type 3 and OI type 4 are more often diagnosed with DI than individuals with OI type 1 [19,26]. Examining dot plots of the data on mesiodistal tooth dimension with emphasis on the different OI types, did not indicate any pattern (data not shown).…”

“…No attempt was made to blind the examiner regarding the two groups (OI versus control) owing to the characteristic tooth morphology of teeth in individuals with OI, and the obvious load of dental treatment in the OI group not found in the control group; both as an effect of the clinical symptoms of OI [19] and the age difference between the groups.…”

“…Forty-seven individuals appeared with OI type 1, one with OI type 3 and nine individuals with OI type 4. The dental examination, carried out as part of this study by Hald et al [18], included a regular clinical examination, clinical photos, intraoral digital radiographs, a digital panoramic radiograph (orthopan) and an alginate impression of both tooth-bearing arches as previously described [19]. The examinations took place at Department of Dentistry and Oral Health, HEALTH, Aarhus University, during the period January 2011 to February 2013.…”