The dementias of schizophrenia

Oliveira‐Souza, Ricardo de; Marrocos, Rogério Paysano; Moll, Jorge

doi:10.1590/s1980-57642008dn10200003

Cited by 4 publications

(2 citation statements)

References 36 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 30 There is a lack of structured psychiatry assessment in differentiating psychiatric diseases from FTLD. 31 There are few reports of cases of FTLD misdiagnosed as schizophrenia but in all such cases the structural neuroimaging exam confirmed the diagnosis of FTLD although carried out in delayed phase. 32 - 34 …”

Section: Discussionmentioning

confidence: 94%

Underdiagnosis of frontotemporal lobar degeneration in Brazil

Bahia

2007

Dement. neuropsychol.

View full text Add to dashboard Cite

Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disorder that involves the frontal and anterior temporal lobes. It is characterized by prominent behavioral and language disorders. There are three variants of FTLD: frontotemporal dementia (FTD), semantic dementia (SD) and progressive non-fluent aphasia (PNFA). FTLD may be mistaken for AD (Alzheimer’s disease) or psychiatric disorders especially in the early stages.ObjectivesTo describe the demographic characteristics of patients with FTLD, assessed at the Behavioral and Cognitive Neurology Unit, and to show that FTLD is commonly clinically under-diagnosed.MethodsAll patients diagnosed with FTLD (Consensus Criteria for FTLD), and who were seen at the Behavioral and Cognitive Neurology Unit of Hospital das Clínicas, in São Paulo, Brazil from January 2004 to August 2007 were included in the analyses.ResultsSixteen patients with FTLD (11 women) were included in this study. There were 12 patients with FTD, two with PNFA and two with SD. The mean duration of the illness until diagnosis of FTLD was 4.1±2.3 years, ranging from one to seven years. Nine patients had been initially seen by psychiatrists, five by neurologists, and two by general physicians. The first diagnosis was psychiatric disorder in six patients, AD in four, dementia in two, FTD in two, and stroke and hydrocephalus for one patient each.ConclusionThe diagnosis of FTLD can be difficult and many patients may be misdiagnosed in Brazil, especially in the initial stages. Educational programs on FTLD for the medical community are warranted.

show abstract

Section: Discussionmentioning

confidence: 94%

Underdiagnosis of frontotemporal lobar degeneration in Brazil

Bahia

2007

Dement. neuropsychol.

View full text Add to dashboard Cite

show abstract

“…The concept of a ‘dementia of schizophrenia’ has been more recently considered (de Oliveira-Souza et al, 2007; de Vries et al, 2001; Gregory et al, 1998; Mitelman and Buchsbaum, 2007). This concept is especially pertinent in those patients with schizophrenia who require long-term or recurrent hospitalisation, or are highly dependent on carers for basic needs if living in the community.…”

Section: Introductionmentioning

confidence: 99%

Comparing neurocognition in severe chronic schizophrenia and frontotemporal dementia

Chan

Stolwyk

Kelso

et al. 2014

Aust N Z J Psychiatry

View full text Add to dashboard Cite

Objective: Previous research has suggested cognitive similarities between schizophrenia and frontotemporal dementia. In the current study, we compared neurocognition in a group of hospitalised patients with chronic schizophrenia, who may have a more severe form of schizophrenia resembling Emil Kraepelin’s dementia praecox, with patients with frontotemporal dementia. We hypothesised minimal group differences in cognitive performance, and a large overlap in between-group score distributions in each cognitive domain. Methods: Retrospective neuropsychological data for 26 patients with severe chronic schizophrenia and 34 patients with frontotemporal dementia (behavioural variant) was collated. Neuropsychological measures were categorised into 16 cognitive domains. Raw scores were converted into standardised z-scores for each measure, which were then averaged across measures within each domain. In addition to difference analysis, equivalence testing was utilised, whereby overlap percentages were computed to reflect the amount of score distribution overlap in each domain between groups. Results: A statistically significant difference was observed only in the executive function sub-domain of Switching. Small-to-moderate and moderate effect sizes were noted in four other domains. Equivalence testing showed more than 85% of overlap in score distribution in most domains. Conclusions: Our findings suggest that some patients with severe chronic schizophrenia have cognitive deficits similar in degree and pattern to patients with frontotemporal dementia. The few differences observed between both groups of patients are important for differential diagnostic purposes. One limitation is the retrospective nature of the study. Suggestions for future research include longitudinal follow-up studies of these two patient populations and studies of aspects beyond neurocognition. An implication of our findings is that the ‘dementia of schizophrenia’ concept may be applicable to patients with severe chronic schizophrenia.

show abstract

Negative Symptoms

Freudenreich¹

2019

Psychotic Disorders

View full text Add to dashboard Cite

The dementias of schizophrenia

Cited by 4 publications

References 36 publications

Underdiagnosis of frontotemporal lobar degeneration in Brazil

Underdiagnosis of frontotemporal lobar degeneration in Brazil

Comparing neurocognition in severe chronic schizophrenia and frontotemporal dementia

Negative Symptoms

Contact Info

Product

Resources

About