The Delta Neutrophil Index is an Early Predictive Marker of Acute Pyelonephritis in Patients with Ureteral Stone

Barut, Osman; Demirkol, Mehmet; Bilecan, Enes Baki; Şahinkanat, Tayfun; Resim, Sefa

doi:10.29271/jcpsp.2020.11.1149

Cited by 4 publications

(3 citation statements)

References 5 publications

(6 reference statements)

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“…An obstructing ureteral stone can cause inflammation, and CRP levels increase. In a study by Barut et al, CRP levels were higher in patients with ureteral stones who had acute pyelonephritis compared with patients with lower urinary tract infections [16]. Yamamichi et al stated that an increase in CRP level was an independent factor in patients with acute pyelonephritis due to proximal obstructing ureteral stones [17].…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Preoperative High-Sensitive C-reactive Protein (hs-CRP)/Albumin Ratio in Systemic Inflammatory Response Syndrome (SIRS) After Semi-rigid Ureteroscopy

Kutluhan¹,

Ünal²,

Özayar³

et al. 2022

Cureus

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Objective: To determine the predictive value of high-sensitive C-reactive protein (hs-CRP)/albumin ratio in systemic inflammatory response syndrome (SIRS) after semi-rigid ureteroscopy (URS).Material and Methods: Between April 2021 and October 2021, 148 patients who had ureteral stone treatment with a ureteroscope in our hospital were included. Preoperative hs-CRP/albumin ratio was obtained by dividing the hs-CRP level by the albumin level. High-sensitivity modified Glasgow prognostic score (hs-mGPS) was obtained according to hs-CRP and albumin values. Two groups were identified as post-URS SIRS positive and negative. Inflammation biomarkers were evaluated in groups.Results: There was a statistically significant difference between groups in terms of preoperative hs-CRP, albumin, and hs-CRP/albumin ratio (p < 0.001, p = 0.003, and p < 0.001, respectively). The optimal cutoff value for the hs-CRP/albumin ratio was 0.04651. While the risk of developing SIRS after surgery was 72.73% in patients with a hs-CRP/albumin ratio higher than 0.04651, the chance of not developing SIRS was 87.5% in patients below this value. The probability of developing SIRS was found to be significantly different in hs-mGPS (p < 0.001). Conclusion:Our study indicated that hs-CRP/albumin ratio can predict post-URS SIRS. Larger-scale, multicentric prospective studies should certainly be done to validate the predictive value of hs-CRP/albumin ratio in post-URS SIRS.

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Section: Discussionmentioning

confidence: 99%

Predictive Value of Preoperative High-Sensitive C-reactive Protein (hs-CRP)/Albumin Ratio in Systemic Inflammatory Response Syndrome (SIRS) After Semi-rigid Ureteroscopy

Kutluhan¹,

Ünal²,

Özayar³

et al. 2022

Cureus

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“…However, in the control group, blood samples were not taken after 3 months, considering that they were systemically and periodontally healthy individuals. However, inflammatory disorders that the person is not even aware of can affect serum DNI values [ 16 , 19 , 27 ]. Therefore, in future studies, serum and blood samples from the control group can be repeated and evaluated during follow-up periods.…”

Section: Discussionmentioning

confidence: 99%

“…The predictive value of DNI for infection and prognosis has been reported to be greater than that of traditional markers, including white blood cell (WBC) count, absolute neutrophil count, and CRP [ 14 , 15 ]. In addition, a significant correlation has been shown between DNI and the severity of other infectious or inflammatory diseases such as rhinosinusitis [ 16 ], sepsis [ 17 ], acute appendicitis [ 18 ], piyelonefrit [ 19 ], and pancreatitis [ 20 ]. Therefore, it has been recommended in many studies that the use of DNI is of clinical benefit as a determinant or marker for early diagnosis, the decision for surgery, and prognosis in patients with various inflammatory and infectious diseases [ 17 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Can delta neutrophil index values predict the success of periodontal treatment in patients with periodontitis?

Özdemir,

Bozkurt,

Yazar

et al. 2024

Clin Oral Invest

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Objectives The aim of this study was to evaluate the effect of delta neutrophil index (DNI) on non-surgical periodontal therapy (NSPT), whose role has been documented in the pathogenesis and follow-up of periodontal disease. Methods and materials The study included 35 patients with stage 3, grade A periodontitis (test group) and 35 patients without periodontal disease (control group). Initially, periodontal parameters were recorded and blood samples were taken from all patients. For patients with periodontitis, periodontal parameter measurements and blood sample analyses were repeated 3 months after NSPT. Results After NSPT, DNI, CRP (C-reactive protein), neutrophil count, WBC (white blood cell), and neutrophil–lymphocyte ratio (NLR) values decreased in the test group, but did not reach a statistically significant level (p > 0.05). When the inflammatory variables were examined, significantly higher CRP, IG (immature granulocytes), DNI, neutrophil count, and WBC were observed in the test group compared to the control group (p < 0.05). In the test group, periodontal parameters were lower 3 months after NSPT than at baseline (p < 0.05). Conclusion Consistent with previous findings in the literature, the patients with periodontitis were determined to have higher levels of DNI, CRP, neutrophils, and WBC, compared to the individuals without periodontitis. Although a decrease was seen in DNI after NSPT, this was not at a significant level. Clinical relevance DNI is a guide in the evaluation of inflammation at the onset of periodontal disease, but studies with a larger number of cases are needed to use these parameters in the evaluation of treatment success. Trial registration This study was retrospectively registered on December 27, 2022, with the number NCT05666622 at http://www.clinicaltrials.gov.

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Delta neutrophil index as a prognostic factor for mortality in patients with Fournier's gangrene

Shin

Gong

et al. 2022

Int J of Urology

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Objectives The delta neutrophil index represents the fraction of circulating immature granulocytes and is a marker of infection and sepsis. Our study aimed to evaluate the usefulness of the delta neutrophil index in predicting mortality in patients with Fournier's gangrene. Methods We enrolled patients with Fournier's gangrene who were admitted to the Wonju Severance Christian Hospital (Wonju, Korea) between September 2010 and December 2021. We retrospectively analyzed the patients' characteristics, factors related to management, scoring systems such as the Fournier's Gangrene Severity Index, and laboratory data measured at initial presentation. Results There were 58 (68.2%) survivors and 27 (31.8%) non‐survivors. The initial levels of serum lactate, hemoglobin, delta neutrophil index, albumin, international normalized ratio, creatinine, Fournier's Gangrene Severity Index, Uludag Fournier's Gangrene Severity Index, and prognostic nutritional index differed between survivors and non‐survivors. Age, international normalized ratio, and delta neutrophil index were independent predictors of mortality in Fournier's gangrene. In receiver operating characteristic curve analysis, delta neutrophil index on the day of admission was the best indicator of mortality (area under the curve, 0.804; 95% confidence interval [0.679–0.929]). The optimal cutoff for delta neutrophil index in predicting mortality was 11.25% (sensitivity, 74.1%; specificity, 91.4%). The initial delta neutrophil index was the best indicator of mortality (area under the curve, 0.804; 95% confidence interval 0.679–0.929). Conclusion The delta neutrophil index can be useful for predicting mortality in patients with Fournier's gangrene. A delta neutrophil index >11.25% at initial presentation is a reliable predictor of Fournier's gangrene.

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The Delta Neutrophil Index is an Early Predictive Marker of Acute Pyelonephritis in Patients with Ureteral Stone

Abstract: Objective: To determine the predictive value of the delta neutrophil index (DNI) for acute pyelonephritis (APN), which increases in conditions of infection and inflammation.

Cited by 4 publications

References 5 publications

Predictive Value of Preoperative High-Sensitive C-reactive Protein (hs-CRP)/Albumin Ratio in Systemic Inflammatory Response Syndrome (SIRS) After Semi-rigid Ureteroscopy

Predictive Value of Preoperative High-Sensitive C-reactive Protein (hs-CRP)/Albumin Ratio in Systemic Inflammatory Response Syndrome (SIRS) After Semi-rigid Ureteroscopy

Can delta neutrophil index values predict the success of periodontal treatment in patients with periodontitis?

Delta neutrophil index as a prognostic factor for mortality in patients with Fournier's gangrene

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