The Delicate Equilibrium between Oxidants and Antioxidants in Brain Glioma

Ramírez-Expósito, María Jesús; Martínez-Martos, José Manuel

doi:10.2174/1570159x16666180302120925

Cited by 54 publications

(41 citation statements)

References 105 publications

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“…One novel finding of the current study is that GSH has a near zero annual change in all brain regions. GSH is the most abundant non-enzymatic antioxidant in the central nervous system (41).…”

Section: Gshmentioning

confidence: 99%

Longitudinal changes in brain metabolites in healthy subjects and patients with first episode psychosis (FEP): a 7-Tesla MRS study

Wang

Barker

Cascella

et al. 2020

Preprint

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OBJECTIVE: 7 Tesla (T) longitudinal magnetic resonance spectroscopy (MRS) offers a precise measurment of metabolic levels in human brain via a non-invasive approach. Studying longitudinal changes in neurometabolites could help identify trait and state markers for diseases and understand inconsistent findings from different researchers due to differences in the age of study participants and duration of illness. This study is the first to report novel longitudinal patterns in young adulthood from both physiological and pathological viewpoints using 7T MRS. METHODS: Utilizing a four-year longitudinal cohort with 38 first episode psychosis (FEP) patients (onset within 2 years) and 48 healthy controls (HC), the authors examined the annual percentage changes of 9 neurometabolites in 5 brain regions. RESULTS: Both FEP patients and HC subjects were found to have significant longitudinal reductions in glutamate (Glu) in the anterior cingulate cortex (ACC). Only FEP patients were found to have a significant decrease over time in gamma-aminobutyric acid (GABA), N-acetyl aspartate (NAA), myo-inositol (mI), and total choline (tCho: phosphocholine plus glycerophosphocholine) in the ACC. Uniquely, glutathione (GSH) was found to have a near zero annual percentage change in both FEP patients and HC subjects in all 5 brain regions over a four-year timespan in young adulthood. CONCLUSIONS: GSH could be a trait marker for diagnostic applications at least in young adulthood. Glu, GABA, NAA, mI, and tCho in the ACC are associated with the patient's status and could be state markers for mechanistic studies of psychotic disorders, including those for progressive pathological changes and medication effects in young adulthood.

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Section: Gshmentioning

confidence: 99%

Longitudinal changes in brain metabolites in healthy subjects and patients with first episode psychosis (FEP): a 7-Tesla MRS study

Wang

Barker

Cascella

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…The products of oxidative modification disrupt cell metabolism and signaling by increasing the production of pro-inflammatory cytokines, modifying gene expression, and promoting apoptotic or necrotic cell death 1 . ROS can be generated in excess from endogenous sources (mitochondria and peroxisomes, but also from the activation of inflammatory cells or the oxidation of neurotransmitters), as well as from exogenous sources, such as different agents present in the environment, radiation, drugs, and chemicals 2 . High oxygen consumption, relatively low antioxidant levels and low regenerative capacity lead to damage of brain tissue because of oxidative stress 3 .…”

Section: Introductionmentioning

confidence: 99%

Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues

Borković-Mitić

Stojsavljević

Vujotić

et al. 2021

Sci Rep

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There are only a few reports examining the impact of oxidative stress in patients with benign and malignant brain tumors. In this study we investigated whether there are changes in antioxidant system (AOS) parameters and key trace elements between control, benign and malignant brain tissues. The study also aimed to examine correlations between the analyzed parameters. The study enrolled both types of brain tumors, benign tumors (BT) and malignant tumors (MT). The results were compared with control tissue (CT) without tumor infiltration collected from patients with BT. The following antioxidant parameters were determined: activities of total, manganese-containing, and copper/zinc-containing superoxide dismutase (TotSOD, MnSOD and CuZnSOD), activities of catalase, glutathione peroxidase, glutathione S-transferase, glutathione reductase and acetylcholine esterase (AChE), the concentrations of glutathione and sulfhydryl groups and of manganese (Mn), copper (Cu), zinc (Zn), and selenium (Se). BT and MT had altered activities/levels of multiple AOS parameters as compared to CT, indicating that tumor cells had an altered cell metabolism and changes in AOS represent adaptive response to increased oxidative stress. Low MnSOD and AChE and high GST activities were significant for distinguishing between MT and CT. Malignant tissue was also characterized by lower Mn and Cu concentrations relative to CT and BT. Principal Component Analysis clearly discriminated BT from CT and MT (PC1, 66.97%), while PC2 clearly discriminated CT from BT and MT (33.03%). Most correlative relationships were associated with Se in the BT group and Cu in the MT group. The results of this study reveal differences between the AOS parameters and the essential trace elements between the analyzed groups. The observed dysregulations show that oxidative stress could have an important role in disrupting brain homeostasis and its presence in the pathogenesis of benign and malignant brain tumors.

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“…The H 2 O 2 , MDA and NO levels were elevated while GSH, t-SH, CAT and SOD levels were decreased at all examined PNDs compared with the control group. Notably, the oxidant-antioxidant balance is essential for normal brain function and development (Ramírez-Exp osito & Martínez-Martos, 2019).…”

Section: Discussionmentioning

confidence: 99%

Maternal LiCl exposure disrupts thyroid–cerebral axis in neonatal albino rats

Mohammed

Ahmed

2021

Intl J of Devlp Neuroscience

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This work aimed to elucidate whether maternal lithium chloride (LiCl) exposure disturbs the thyroid-cerebral axis in neonatal albino rats. 50 mg of LiCl/ kg b.wt. is orally given for pregnant Wistar rats from gestational day (GD) 1 to lactation day (LD) 28. The maternal administration of LiCl induced follicular dilatation and degeneration, hyperplasia, lumen obliteration and colloid vacuolation in the maternal and neonatal thyroid gland at postnatal days (PNDs) 14, 21 and 28. Neuronal degeneration (spongiform), gliosis, nuclear pyknosis, perivascular oedema, and meningeal hyperaemia were observed in the neonatal cerebral cortex of the maternal LiCl-treated group at examined PNDs. This disturbance appears to depend on intensification in the neonatal cerebral malondialdehyde (MDA), nitric oxide (NO), and hydrogen peroxide (H 2 O 2 ) levels, and attenuation in the glutathione (GSH), total thiol (t-SH), catalase (CAT), and superoxide dismutase (SOD) levels. In the neonatal cerebrum, the fold change in the relative mRNA expression of deiodinases (DII and DIII) increased significantly at PNDs 21 and 14, respectively, in the maternal LiCltreated group. These data suggest that maternal LiCl may perturb the thyroidcerebrum axis generating neonatal neurodevelopmental disorder.

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The Delicate Equilibrium between Oxidants and Antioxidants in Brain Glioma

Cited by 54 publications

References 105 publications

Longitudinal changes in brain metabolites in healthy subjects and patients with first episode psychosis (FEP): a 7-Tesla MRS study

Longitudinal changes in brain metabolites in healthy subjects and patients with first episode psychosis (FEP): a 7-Tesla MRS study

Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues

Maternal LiCl exposure disrupts thyroid–cerebral axis in neonatal albino rats

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