The deleterious effect of xylene-induced ear edema in rats: Protective role of dexketoprofen trometamol transdermal invasomes via inhibiting the oxidative stress/NF-κB/COX-2 pathway

Soliman, Sara M.; Teaima, Mahmoud H.; Rashwan, Kareem Omar; Ali, Bassam Mohamed; Jasti, Bhaskara; El-Nabarawi, Mohamed A.; El-Halim, Shady M. Abd

doi:10.1016/j.ijpharm.2022.122525

Cited by 4 publications

(4 citation statements)

References 49 publications

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“…However, our research indicates that both benzene and ortho/meta-xylene have an impact on human hearing loss. Literature review reveals that ortho/meta-xylene can induce ear edema, oxidative stress, and inflammation, while also causing constriction or damage to vascular endothelium, and para-xylene can reduce potassium ion concentration in lymph fluid [ 56 , 57 ]. These factors could potentially hinder blood supply to the cochlea or lymphatic reflux, ultimately leading to dysfunction of the cochlear organ.…”

Section: Discussionmentioning

confidence: 99%

“…Studies investigating the effects of benzene and the three isomers of xylene on hearing loss in rats have found that only m-/p-xylene has ototoxic effects on hair cells [54,55]. However, our [56,57]. These factors could potentially hinder blood supply to the cochlea or lymphatic reflux, ultimately leading to dysfunction of the cochlear organ.…”

Section: Discussionmentioning

confidence: 99%

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Association between blood volatile organic aromatic compound concentrations and hearing loss in US adults

Wang,

Luo,

Zhang

et al. 2024

BMC Public Health

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Objective Benzene, ethylbenzene, meta/para-xylene, and ortho-xylene, collectively referred to as benzene, ethylbenzene, and xylene (BEX), constitute the main components of volatile organic aromatic compounds (VOACs) and can have adverse effects on human health. The relationship between exposure to BEX and hearing loss (HL) in the adult U.S. population was aimed to be assessed. Methods Cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) for the years 2003–2004, 2011–2012, and 2015–2016 were analyzed. This dataset included complete demographic characteristics, pure-tone audiometry measurements, and volatile organic compound detection data from the NHANES database. A weighted multivariate logistic regression model was employed to investigate the associations between blood BEX concentrations HL, low-frequency hearing loss (SFHL), and high-frequency hearing loss (HFHL). Results 2174 participants were included, with weighted prevalence rates of HL, SFHL, and HFHL being 46.81%, 25.23%, and 45.86%, respectively. Exposure to benzene, ethylbenzene, meta/para-xylene, and ortho-xylene, and cumulative BEX concentrations increased the risk of hearing loss (odds ratios [ORs] were 1.36, 1.22, 1.42, 1.23, and 1.31, respectively; all P < 0.05). In the analysis with SFHL as the outcome, ethylbenzene, m-/p-xylene, o-xylene, benzene, and overall BEX increased the risk (OR 1.26, 1.21, 1.28, 1.20, and 1.25, respectively; all P < 0.05). For HFHL, exposure to ethylbenzene, m-/p-xylene, o-xylene, benzene, and overall BEX increased the risk (OR 1.36, 1.22, 1.42, 1.22, and 1.31, respectively; all P < 0.05). Conclusion Our study indicated that a positive correlation between individual or cumulative exposure to benzene, ethylbenzene, meta/para-xylene, and ortho-xylene and the risk of HL, SFHL, and HFHL. Further research is imperative to acquire a more comprehensive understanding of the mechanisms by which organic compounds, notably BEX, in causing hearing loss and to validate these findings in longitudinal environmental studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between blood volatile organic aromatic compound concentrations and hearing loss in US adults

Wang,

Luo,

Zhang

et al. 2024

BMC Public Health

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“…15 The ability to multiple drug entrapment along with high skin permeability can make these vesicles as a suitable option to create appropriate skin formulations. 16,17 Bupivacaine and buprenorphine are classified as strong local analgesics and opioids, respectively, 18 but due to their physicochemical properties, they do not have suitable conditions for skin penetration. Concomitant use of opioids and local anaesthetics may have a synergistic effect and may also block skin-concentrated opioid receptors and free nerve endings simultaneously.…”

Section: Introductionmentioning

confidence: 99%

“…These vesicles are mainly composed of phospholipids, ethanol and terpenes that give soft and flexible properties 15 . The ability to multiple drug entrapment along with high skin permeability can make these vesicles as a suitable option to create appropriate skin formulations 16,17 . Bupivacaine and buprenorphine are classified as strong local analgesics and opioids, respectively, 18 but due to their physicochemical properties, they do not have suitable conditions for skin penetration.…”

Section: Introductionmentioning

confidence: 99%

Nano‐invasomes for simultaneous topical delivery of buprenorphine and bupivacaine for dermal analgesia

Babaie

Charkhpour

Kouhsoltani

et al. 2023

Experimental Dermatology

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Opioid and local anaesthetic receptors are abundantly concentrated in different layers of the skin. Therefore, simultaneous targeting of these receptors can produce more potent dermal anaesthesia. Herein, we developed lipid‐based nanovesicles for the co‐delivery of buprenorphine and bupivacaine to efficiently target skin‐concentrated pain receptors. Invasomes incorporating two drugs were prepared by ethanol injection method. Subsequently, the size, zeta potential, encapsulation efficiency, morphology, and in‐vitro drug release of vesicles were characterized. Ex‐vivo penetration features of vesicles were then investigated by the franz diffusion cell on the full‐thickness human skin. Wherein, it was demonstrated that invasomes penetrated the skin deeper and delivered bupivacaine more effectively than buprenorphine to the target site. The superiority of invasome penetration was further evidenced by the results of ex‐vivo fluorescent dye tracking. Estimation of in‐vivo pain responses by the tail‐flick test revealed that compared with the liposomal group, the group receiving invasomal formulation and drug‐free invasomal formulation (only containing menthol) displayed increased analgesia in the initial times of 5 and 10 min. Also, no signs of oedema or erythema were observed in the Daze test in any of the rats receiving the invasome formulation. Finally, ex‐vivo and in‐vivo assays demonstrated efficiency in delivering both drugs into deeper layers of skin and exposing them to the located pain receptors, which improves the time of onset and the analgesic effects. Hence, this formulation appears to be a promising candidate for tremendous development in the clinical setting.

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Investigating the efficacy of mirtazapine-embedded invasomal gel nanocarriers via I-optimal design for management of atopic dermatitis

Ibrahim,

Abdulla,

Mohamed

2024

Journal of Drug Delivery Science and Technology

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The deleterious effect of xylene-induced ear edema in rats: Protective role of dexketoprofen trometamol transdermal invasomes via inhibiting the oxidative stress/NF-κB/COX-2 pathway

Cited by 4 publications

References 49 publications

Association between blood volatile organic aromatic compound concentrations and hearing loss in US adults

Association between blood volatile organic aromatic compound concentrations and hearing loss in US adults

Nano‐invasomes for simultaneous topical delivery of buprenorphine and bupivacaine for dermal analgesia

Investigating the efficacy of mirtazapine-embedded invasomal gel nanocarriers via I-optimal design for management of atopic dermatitis

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