The Deimination of Arginine to Citrulline

Creese, Andrew J.; Cooper, Helen J.

doi:10.1002/9781119250906.ch7

Cited by 1 publication

(1 citation statement)

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“…Deamidation can occur on the side chain (glutamine or asparagine) or on an amidated C-terminus whenever the hydrolysis of an amide group results in the formation of a carboxylated group [53,66,67]. Similar to deamidation, deimination is the conversion of an arginine residue into a citrulline residue resulting in a mass shift of 1 Da [68].…”

Section: Classification Of Peptide Impuritiesmentioning

confidence: 99%

Establishment of measurement traceability for peptide and protein quantification through rigorous purity assessment—a review

Josephs

Martos

et al. 2019

Metrologia

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The health of their populations and efficient health care systems are of critical importance to the economic and social well-being of nations. Accurate and comparable peptide/protein measurements are required in support of diagnosis, prognosis, monitoring and treatment of widespread diseases (e.g. diabetes). The required consistency of measurement results can be achieved by making them traceable to stated references and through the development of Reference Measurement Systems. The review mainly concentrates on the progress made in the Protein Analysis Working Group of the Consultative Committee for Amount of Substance: Metrology in Chemistry and Biology (CCQM-PAWG) in establishing Primary Calibration Reference Services in the emerging area of health markers such as peptides/proteins. Primary Calibration Reference Services are technical capabilities for composition assignment, commonly as the mass fraction content, of pure substances or solutions thereof. It is a core technical competency for National Measurement Institutes (NMIs). A limited number of key comparisons, foreseen by the CCQM-PAWG strategy, are discussed that enable NMIs providing measurement services in peptide/protein analysis to test and demonstrate their capabilities. In addition, the review examines the development and improvement of analytical methods and metrological models that are required to meet the needs of NMIs and associated clinical stakeholders.

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