For a graph G, the resistance distance r G ( x , y ) is defined to be the effective resistance between vertices x and y, the multiplicative degree-Kirchhoff index R ∗ ( G ) = ∑ { x , y } ⊂ V ( G ) d G ( x ) d G ( y ) r G ( x , y ) , where d G ( x ) is the degree of vertex x, and V ( G ) denotes the vertex set of G. L. Feng et al. obtained the element in C a c t ( n ; t ) with first-minimum multiplicative degree-Kirchhoff index. In this paper, we first give some transformations on R ∗ ( G ) , and then, by these transformations, the second-minimum multiplicative degree-Kirchhoff index and the corresponding extremal graph are determined, respectively.