The degree of depression in Hamilton rating scale is correlated with the density of presynaptic serotonin transporters in 23 patients with Wilson's disease

Eggers, Birk; Hermann, W.; Barthel, Henryk; Sabri, Osama; Wagner, A.; Hesse, Swen

doi:10.1007/s00415-003-1039-7

Cited by 49 publications

(32 citation statements)

References 19 publications

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“…Using [ 123 I] -CIT SPECT, it was found that the severity of depression was negatively correlated with the SERT availability in the thalamus/hypothalamus region [637,638]. In the midbrain, WD patients showed significantly lower SERT availability, compared to healthy controls, regardless of whether depression was evident or not [148].…”

Section: Serotonin Transporter Imaging In Neurological Diseasesmentioning

confidence: 96%

Neuroimaging of the Serotonin Transporter: Possibilities and Pitfalls

Brust¹,

Hesse²,

Müller³

et al. 2006

CPSR

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Nuclear medicine imaging techniques like positron emission tomography (PET) and single-photon emission computed tomography (SPECT) apply radiolabeled drugs that bind selectively to specific neurotransmitter receptors and transporters such as the serotonin transporter (SERT) in the living human brain. They can help overcome certain limitations of postmortem, platelet and genetic studies of the SERT. This review compares the outcome of those studies with recent neuroimaging findings. The first part of this review deals with the choice of radioligands used to quantify SERT distribution in the human brain. The second part summarizes studies performed to understand the normal physiology of the serotonergic system. Selective serotonin reuptake inhibitors (SSRIs), used to treat a wide range of neuropsychiatric disorders with emotional instability and behavioral control deficits, compete with SERT radioligands and have been investigated in pharmacological PET and SPECT studies in healthy volunteers and patients. Part three reviews SERT imaging studies in patients, which have meanwhile been performed in most disorders that benefit from SSRI treatment. It is hypothesized that serotonin deficits and neuropsychiatric symptoms are linked by the inhibition of involuntary emotional reactions to external and internal stimuli. This could explain, why the consistency of many SERT neuroimaging findings is low, and may help develop individual treatment strategies in therapy-nonresponsive cases and to engineer new drugs for the therapy of neuropsychiatric disorders.

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Section: Serotonin Transporter Imaging In Neurological Diseasesmentioning

confidence: 96%

Neuroimaging of the Serotonin Transporter: Possibilities and Pitfalls

Brust¹,

Hesse²,

Müller³

et al. 2006

CPSR

View full text Add to dashboard Cite

show abstract

“…Furthermore, reduced 5-HTT availability, as putatively indexed by the 5-HTTLPR short allele, has been associated with mood disturbances, including major depression (especially in the context of environmental stressors; Caspi et al, 2003;Eley et al, 2004;Kaufman et al, 2004;Kendler, Kuhn, Vittum, Prescott, & Riley, 2005;Malison et al, 1998), as well as with more severe depression and anxiety in various psychiatric disorders (Eggers et al, 2003;Heinz et al, 2002;Willeit et al, 2000).…”

Section: Serotonin-transporter Genetic Variation and Individual Diffementioning

confidence: 99%

Neuroimaging studies of serotonin gene polymorphisms: Exploring the interplay of genes, brain, and behavior

Brown

Hariri

2006

Cognitive, Affective, & Behavioral Neuroscience

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Because of the unique ability it provides to investigate information processing at the level of neural systems, functional neuroimaging is a powerful tool to explore the relationship between genes, brain, and behavior. Recently, functional neuroimaging has provided dramatic illustrations of how a promoter polymorphism in the human serotonin transporter gene, which has been weakly related to several dimensions of emotional behaviors (such as neuroticism and anxiety traits), is strongly related to the engagement of neural systems-namely, the amygdala and subgenual prefrontal cortex, subserving emotional information processing. This review will outline the experimental strategy by which these genetic effects on brain function have been explored and highlight the effectiveness of this strategy to delineate biological pathways and mechanisms contributing to the emergence of individual differences in brain function that potentially bias behavior and risk for psychiatric illness.

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“…Decreased serotonin transporter densities (SERT) have been recorded from the brains of depressed patients [1,2], which have also been reported to normalise during psychotherapy [3,4]. A few studies have also revealed altered levels of dopamine transmission in major depression [5,6].…”

Section: Introductionmentioning

confidence: 99%

Elevated midbrain serotonin transporter availability in mixed mania: a case report

et al. 2004

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The degree of depression in Hamilton rating scale is correlated with the density of presynaptic serotonin transporters in 23 patients with Wilson's disease

Abstract: We conclude that depression in patients with Wilson's disease is correlated with alterations of serotonergic neurotransmission in the thalamus-hypothalamus region.

Cited by 49 publications

References 19 publications

Neuroimaging of the Serotonin Transporter: Possibilities and Pitfalls

Neuroimaging of the Serotonin Transporter: Possibilities and Pitfalls

Neuroimaging studies of serotonin gene polymorphisms: Exploring the interplay of genes, brain, and behavior

Elevated midbrain serotonin transporter availability in mixed mania: a case report

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