The Degree of Coronary and Aortic Atherosclerosis in Necropsied Cases of Multiple Myeloma

Spain, David M.; Greenblatt, I. J.; Snapper, I.; Cohn, Theodore E.

doi:10.1097/00000441-195623120-00007

Cited by 6 publications

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“…Low serum cholesterol levels are often found in patients with myelomatosis and macroglobulinaemia (7,13,17,18). This is in harmony with the fact that autopsy rarely reveals atherosclerosis in such patients (13,14).…”

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confidence: 73%

Waldenstrom's Macroglobulinaemia With Xanthomatosis and Hypercholesterolaemia

Petersen

1973

Journal of Internal Medicine

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Even though most cases of M‐globulinaemia reveal low serum cholesterol values, a few cases are on record in which hypercholesterolaemia and/or xanthomatosis have been associated with IgG or IgA para‐proteinaemia. In most of the latter cases a familial origin of the disease was not disclosed, and a causal relationship between the paraproteinaemia and the lipoid disease was therefore assumed. A report is presented of a case associated with Waldenström's macroglobulinaemia—a combination which does not seem to have been described before. This case probably represents a fortuitous coincidence of the two diseases, as electrophoresis of the serum lipoproteins in the patient's sister revealed lipoid changes, although this sister had no xanthomata and her serum cholesterol level was only at the upper limit of normal. Thus a familial genesis can be excluded only by an analysis of serum lipoids in members of the family.

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confidence: 73%

Waldenstrom's Macroglobulinaemia With Xanthomatosis and Hypercholesterolaemia

Petersen

1973

Journal of Internal Medicine

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“…In some of the myeloma patients with hypocholesterolemia, an affinity of paraprotein towards lipoprotein was also demonstrated [38,51,57,61]. It has been speculated that the paraprotein opsonises the lipoprotein followed by degradation by macrophages [50].…”

Section: Discussionmentioning

confidence: 99%

Hyperlipidemic myeloma: review of 53 cases

et al. 2009

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Hyperlipidemic myeloma is a rare and poorly understood variant of multiple myeloma. We report the case of a 53-year-old woman with hyperlipidemic myeloma, skin xanthomas and hyperviscosity syndrome who underwent allogeneic bone marrow transplantation. A comprehensive literature search identified 52 additional cases with plasma cell disease and hyperlipidemia. A detailed analysis revealed several characteristics of these patients as compared to multiple myeloma with normal lipid status: (1) IgA paraprotein was present in the majority (53% vs. 21% in classical multiple myeloma). (2) Skin xanthomas, especially in the palmar creases, elbows, and knees were common (70%). (3) Hyperviscosity syndrome occurred more often (26% vs. 2-6%). While conventional lipid-lowering therapy had only marginal effects, successful anti-myeloma therapy also reduced hyperlipidemia. Analyses of the mechanisms leading to hyperlipidemia documented complexes of paraprotein and lipoprotein in 75% of the 32 cases tested, suggesting an inhibitory role of the paraprotein on lipid degradation. In conclusion, the clinical characteristics, the therapeutic options, and the pathophysiologic mechanisms of hyperlipidemic myeloma are comprehensively reported using the available data from all 53 published cases in the literature.

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“…A high proportion of /8to al-lipoprotein was found in three of the patients. Snapper (Spain et al, 1956) found no case of coronary occlusion among his extensive series of patients with myelomatosis. He and his colleagues compared the post-mortem coronary and aortic atherosclerosis in 104 cases of multiple myeloma with two control groups, one dying a violent death and the other dying from cancer.…”

Section: Discussionmentioning

confidence: 98%

Myelomatosis with Lipaemia and Xanthomata

Lennard‐Jones¹

1960

BMJ

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The Degree of Coronary and Aortic Atherosclerosis in Necropsied Cases of Multiple Myeloma

Cited by 6 publications

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Waldenstrom's Macroglobulinaemia With Xanthomatosis and Hypercholesterolaemia

Waldenstrom's Macroglobulinaemia With Xanthomatosis and Hypercholesterolaemia

Hyperlipidemic myeloma: review of 53 cases

Myelomatosis with Lipaemia and Xanthomata

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