The Degree of Anisocytosis Predicts Survival in Patients with Primary Myelofibrosis

Lucijanić, Marko; Pejša, Vlatko; Jakšić, Ozren; Mitrović, Zdravko; Tomasović-Lončarić, Čedna; Štoos‐Veić, Tajana; Prka, Željko; Piršić, Mario; Hariš, Višnja; Vasilj, Tamara; Kušec, Rajko

doi:10.1159/000445247

Cited by 19 publications

(14 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oppositely to microcytosis, higher heterogeneity of erythrocyte size (i.e. anisocytosis, measured as RDW) seems to be associated with anemia and predictive of inferior survival, but not correlated with iron metabolism parameters in PMF [33]. These findings indicate that MCV and RDW, although useful for recognition of iron deficiency anemia in general population, might be suboptimal for this purpose in PMF.…”

Section: Discussionmentioning

confidence: 78%

Prognostic implications of low transferrin saturation in patients with primary myelofibrosis

et al. 2018

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 78%

Prognostic implications of low transferrin saturation in patients with primary myelofibrosis

et al. 2018

Self Cite

View full text Add to dashboard Cite

“…Our most interesting observation is the prognostic potential of ABC. ABC correlated with different known negative prognostic factors in PMF such as the DIPSS score [7] and related factors (WBC, circulatory blasts and constitutional symptoms), LDH [9], RDW [10] and AMC [11]. In addition, ABC bears powerful prognostic properties itself.…”

Section: Discussionmentioning

confidence: 89%

“…Besides factors included into the currently established prognostic scores, a variety of other disease-associated parameters can contribute to better prognostic discrimination in PMF patients, such as lactate dehydrogenase (LDH) levels [9], red cell distribution width (RDW) [10] and monocytosis in the peripheral blood [11]. Elevation in the number of circulatory basophils is a known feature of both chronic myelogenous leukemia (CML) and Ph-MPNs [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

High absolute basophil count is a powerful independent predictor of inferior overall survival in patients with primary myelofibrosis

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Cardiovascular diseases might therefore be considered as "complications" of myeloproliferative disease and similar associations of different prognostic parameters [46,47] (including MPV) with survival are not surprising.…”

Section: By a Literature Review It Is Currently Not Clear How And Tomentioning

confidence: 98%

Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis

et al. 2017

Self Cite

View full text Add to dashboard Cite

Neoplastic megakaryopoiesis is a dominant feature of Philadelphia-chromosome-negative myeloproliferative neoplasms (Ph- MPNs), and elevated mean-platelet-volume (MPV) is a common finding in these diseases. The clinical and prognostic significances of MPV in patients with primary (PMF) and secondary myelofibrosis (SMF) have not been reported. We retrospectively analyzed 87 patients with myelofibrosis (66 with PMF, 21 with SMF) treated at our institution. MPV was recorded in addition to other hematological and clinical parameters. MPV was elevated in both PMF and SMF patients in comparison to controls, whereas there was no statistically significant difference between PMF and SMF. Elevated MPV was associated with lower platelets (P = 0.016), higher white blood cells (P = 0.015), higher percentage of circulatory blasts (P = 0.009), higher lactate dehydrogenase (P = 0.011), larger spleen size (P = 0.014) and higher Dynamic International Prognostic score category (P = 0.027), while there was no statistically significant association with driver mutations or degree of bone marrow fibrosis. Higher MPV was univariately associated with inferior overall survival in the whole cohort (HR = 3.82, P = 0.006), PMF (HR = 4.35, P = 0.007) and SMF patients (HR = 7.22, P = 0.034). These associations remained significant in multivariate analyses adjusted for DIPSS. Higher MPV is associated with more aggressive disease features and exhibits powerful independent prognostic properties in both PMF and SMF settings.

show abstract

The Degree of Anisocytosis Predicts Survival in Patients with Primary Myelofibrosis

Cited by 19 publications

References 8 publications

Prognostic implications of low transferrin saturation in patients with primary myelofibrosis

Prognostic implications of low transferrin saturation in patients with primary myelofibrosis

High absolute basophil count is a powerful independent predictor of inferior overall survival in patients with primary myelofibrosis

Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis

Contact Info

Product

Resources

About