The Degradation of Collagen in Pig Synoviurn in Vitro and the Effect of Colchicine

Fell, Honor B.; Lawrence, Christopher E.; Bagga, M. R.; Hembry, Rosalind M.; Reynolds, John J.

doi:10.1016/s0934-8832(89)80029-0

Cited by 13 publications

(3 citation statements)

References 22 publications

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“…Colchicines cause a collapse of the cisternae of the granular endoplasmic reticulum in myofibroblasts, a reduction in the number of myofilaments and the disappearance of intracellular collagen fibers [7]. It also interferes with the transcellular movement of collagen and diminishes the activity of the enzymes responsible for collagen processing [10,13]. Akkuş et al published the first pilot study in which they administered oral colchicines to 24 patients with early-stage PD [1].…”

Section: Discussionmentioning

confidence: 99%

Does Smoking Change the Efficacy of Combination Therapy With Vitamin E and Colchicines in Patients With Early-Stage Peyronie's Disease?

Çakan¹,

Demirel²,

Aldemir³

et al. 2006

Archives of Andrology

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This study was conducted to find out if smoking has an effect on the results of combination therapy with vitamin E and colchicines in patients with early-stage Peyronie's disease (PD). A total of 58 potent patients suffering from early-stage PD were included in the study (mean age 47.3 years, range 25-73 y). The time from onset of the disease was <6 months and no patient had ED. The patients with severe fibrotic or calcified plaques were not included in the study. Of the patients, 36 were smokers (Group 1) and 22 were non-smokers (Group 2). All the patients received vitamin E (800 IU daily) and colchicines (1 mg daily) for 6 months. Follow-up ranged from 5 to 13 months (mean 10.3 m). The combination therapy was effective and well tolerated in both groups. There were no significant differences between the two groups according to age, disease duration, related disease (diabetes, hypertension, hypercholesterolemia, and hypertriglyceridemia), plaque sizes, and plaque numbers. The resolution in pain and increase in penile curvature and plaque size were similar rates in both groups (p > 0.05), while decrease in penile curvature and plaque size were higher in Group 2 (p < 0.05). No patient discounted the therapy due to side effects. The oral combination therapy with vitamin E and colchicines appears to be an effective procedure in patients with early-stage PD and smoking may have worsening effects on the treatment results.

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Section: Discussionmentioning

confidence: 99%

Does Smoking Change the Efficacy of Combination Therapy With Vitamin E and Colchicines in Patients With Early-Stage Peyronie's Disease?

Çakan¹,

Demirel²,

Aldemir³

et al. 2006

Archives of Andrology

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“…According to a literature review, colchicine can restrict procollagen synthesis, increase collagenase activity, and block mast cell release of histamine. It can also reduce the production of TNF-α that is caused by LPS [82][83][84]. Hence, autoimmune illnesses can be managed using their immunomodulatory effects.…”

Section: Alkaloidsmentioning

confidence: 99%

Perspective Chapter: Phytocompounds as Immunomodulators

Cherian,

Vadivel

2023

Immunosuppression and Immunomodulation

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Healthy operation of every organ depends on immune cells. T-cells, B-cells, and natural killer cells that control the immune homeostasis. Immunotherapy includes the process by which immune cells are immunomodulated. Immunological responses can be induced by immunostimulants, amplified by immune boosters, attenuated by immunomodulators, and prevented by immunosuppressive agents, according to therapeutic techniques. The over-activation of the immune system is mostly to blame for the rise of chronic immunological illnesses such as viral infections, allergies, and cancer. Immunomodulators may also be used to control the severity of long-term immunological diseases. Additionally, it is discovered that these immunomodulator-acting proteins represent prospective molecular targets for the control of the immune system. Furthermore, it is well known that organic molecules like phytocompounds have the ability to bind to these locations and affect the immune system. Curcumin, quercetin, stilbenes, flavonoids, and lignans are examples of specific phytocompounds shown to have immunomodulatory properties to address immunological diseases.

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“…Colchicine is an agent with anti-inflammatory activity that can decrease collagen synthesis and stimulate collagenase activity (Harris and Krane, 1971). Colchicine interferes with the transcellular movement of collagen and diminishes the activity of the enzymes responsible for collagen processing (Harris and Krane, 1971;Fell et al, 1989). Akkus and colleagues reported on 24 patients treated with colchicine in a noncontrolled study for 3 to 5 months, with 11% reporting a slight decrease in cur-vature, 26% reporting a marked decrease in curvature, and 50% observing a decrease in plaque size (Akkus et al, 1994).…”

Section: Medical Therapymentioning

confidence: 99%