The defect of SFRP2 modulates an influx of extracellular calcium in B lymphocytes

Tokuda, Yoshiyuki; Tanaka, Masami; Yagi, T.; Tashiro, Kei

doi:10.1186/1756-0500-7-780

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…SFRP2 and LGR5 were among the top 25 upregulated genes in pinguecula. They function as negative regulators of Wnt signaling in B-cells [ 68 , 69 ]. Moreover, upregulated specifically in pinguecula, SFRP4 , is a negative regulator of Wnt signaling in T-cells [ 70 ].…”

Section: Resultsmentioning

confidence: 99%

Transcriptome Analysis of Pterygium and Pinguecula Reveals Evidence of Genomic Instability Associated with Chronic Inflammation

Suárez

Echenique

López

et al. 2021

IJMS

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Solar damage due to ultraviolet radiation (UVR) is implicated in the development of two proliferative lesions of the ocular surface: pterygium and pinguecula. Pterygium and pinguecula specimens were collected, along with adjacent healthy conjunctiva specimens. RNA was extracted and sequenced. Pairwise comparisons were made of differentially expressed genes (DEGs). Computational methods were used for analysis. Transcripts from 18,630 genes were identified. Comparison of two subgroups of pterygium specimens uncovered evidence of genomic instability associated with inflammation and the immune response; these changes were also observed in pinguecula, but to a lesser extent. Among the top DEGs were four genes encoding tumor suppressors that were downregulated in pterygium: C10orf90, RARRES1, DMBT1 and SCGB3A1; C10orf90 and RARRES1 were also downregulated in pinguecula. Ingenuity Pathway Analysis overwhelmingly linked DEGs to cancer for both lesions; however, both lesions are clearly still benign, as evidenced by the expression of other genes indicating their well-differentiated and non-invasive character. Pathways for epithelial cell proliferation were identified that distinguish the two lesions, as well as genes encoding specific pathway components. Upregulated DEGs common to both lesions, including KRT9 and TRPV3, provide a further insight into pathophysiology. Our findings suggest that pterygium and pinguecula, while benign lesions, are both on the pathological pathway towards neoplastic transformation.

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Section: Resultsmentioning

confidence: 99%

Transcriptome Analysis of Pterygium and Pinguecula Reveals Evidence of Genomic Instability Associated with Chronic Inflammation

Suárez

Echenique

López

et al. 2021

IJMS

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“…DEGs ( WNT3A , IGFBP3 , BMP7 , and SFRP2 ) were enriched in GO terms, which are related to regulation of developmental growth, developmental process, organ morphogenesis, and embryonic appendage morphogenesis. Wnt pathway is one of the key signal mechanisms related to cell differentiation during embryogenesis, hematopoiesis, and carcinogenesis [ 36 ]. Kishimoto et al [ 37 ] established that WNT3A as inductive signals maintained the mouse dermal papilla (DP) in an anagen state.…”

Section: Discussionmentioning

confidence: 99%

De Novo Transcriptome Sequencing Analysis of Goose (Anser anser) Embryonic Skin and the Identification of Genes Related to Feather Follicle Morphogenesis at Three Stages of Development

Liu

Sello

Sun

et al. 2018

IJMS

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The objective of this study was to evaluate the changes in the goose embryo transcriptome during feather development. RNA-Sequencing (RNA-Seq) was used to find the transcriptome profiles of feather follicles from three stages of embryonic dorsal skin at embryonic day 13, 18, and 28 (E13, E18, E28). The results showed that 3001, 6634, and 13,780 genes were differently expressed in three stages. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that differentially expressed genes (DEGs) in E13 vs. E18 were significantly mapped into the GO term of extracellular structure organization and the pathway of extracellular matrix (ECM)-receptor interaction. In E18 vs. E28, the top significantly mapped into GO term was the single-organism developmental process; the pathway was also the ECM-receptor interaction. DEGs in E13 vs. E28 were significantly mapped into the GO term of the multicellular organismal process and the pathway of cell adhesion molecules. Subsequently, the union of DEGs was categorized by succession cluster into eight profiles, which were then grouped into four ideal profiles. Lastly, the seven genes spatio-temporal expression pattern was confirmed by real-time PCR. Our findings advocate that interleukin 20 receptor subunit alpha (IL20RA), interleukin 6 receptor (IL6R), interleukin 1 receptor type 1 (IL-1R1), Wnt family member 3A (WNT3A), insulin-like growth factor binding protein 3 (IGFBP3), bone morphogenetic protein 7 (BMP7), and secreted-frizzled related protein 2 (SFRP2) might possibly play vital roles in skin and feather follicle development and growth processes.

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“…The Wnt signaling is critical for differentiation of HSCs into B cells with normal function. Unlike the fact that there is a compelling study in Wnt-regulated T cell development, studies in functions of Wnt signaling in B cells are currently limited, although there are several lines of direct evidence of aberrant Wnt signals in B cells which were related to autoimmunity [ 59 , 80 , 81 ]. For example, the Wnt canonical pathway could induce B-1 cell survival and proliferation by stimulating the expression of Wnt target genes of c-Myc and cyclin D1 [ 59 ].…”

Section: Regulatory Roles Of Wnt Signaling In Immune Cellsmentioning

confidence: 99%

Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

Shi

Chi

Xue

et al. 2016

Journal of Immunology Research

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The Wnt signaling pathway plays a key role in many biological aspects, such as cellular proliferation, tissue regeneration, embryonic development, and other systemic effects. Under a physiological condition, it is tightly controlled at different layers and arrays, and a dysregulated activation of this signaling has been implicated into the pathogenesis of various human disorders, including autoimmune diseases. Despite the fact that therapeutic interventions are available for ameliorating disease manifestations, there is no curative therapy currently available for autoimmune disorders. Increasing lines of evidence have suggested a crucial role of Wnt signaling during the pathogenesis of many autoimmune diseases; in addition, some of microRNAs (miRNAs), a class of small, noncoding RNA molecules capable of transcriptionally regulating gene expression, have also recently been demonstrated to possess both physiological and pathological roles in autoimmune diseases by regulating the Wnt signaling pathway. This review summarizes currently our understanding of the pathogenic roles of Wnt signaling in several major autoimmune disorders and miRNAs, those targeting Wnt signaling in autoimmune diseases, with a focus on the implication of the Wnt signaling as potential biomarkers and therapeutic targets in immune diseases, as well as miRNA-mediated regulation of Wnt signaling activation in the development of autoimmune diseases.

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The defect of SFRP2 modulates an influx of extracellular calcium in B lymphocytes

Cited by 4 publications

References 26 publications

Transcriptome Analysis of Pterygium and Pinguecula Reveals Evidence of Genomic Instability Associated with Chronic Inflammation

Transcriptome Analysis of Pterygium and Pinguecula Reveals Evidence of Genomic Instability Associated with Chronic Inflammation

De Novo Transcriptome Sequencing Analysis of Goose (Anser anser) Embryonic Skin and the Identification of Genes Related to Feather Follicle Morphogenesis at Three Stages of Development

Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

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