The Declaration of Helsinki in bioethics literature since the last revision in 2013

Ehni, Hans‐Jörg; Wiesing, Urban

doi:10.1111/bioe.13270

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2024

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Cited by 4 publications

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Catching the next wave? The relationship between UNESCO and developments in genomics

Feeney

2024

Eur J Hum Genet

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Catching the next wave? The relationship between UNESCO and developments in genomics

Feeney

2024

Eur J Hum Genet

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60th anniversary of the Declaration of Helsinki: ethical challenges in the 10th amendment

Hellmann,

Marceau,

Cruz

2024

J R Soc Med

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Association between serum vitamin D status and severity of liver cirrhosis: implications for therapeutic targeting in Nigerian patients

Adiri,

Basil,

Onyia

et al. 2024

BMC Gastroenterol

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Background Liver cirrhosis is a chronic and progressive liver disease with significant global health implications. Recent evidence suggests an association between serum vitamin D levels and the severity of liver cirrhosis, potentially serving as a therapeutic target. This study aimed to investigate the relationship between serum vitamin D status and the severity of liver cirrhosis in a population of Nigerian patients. Methods This analytical, cross-sectional study involved 201 participants, including 103 with liver cirrhosis and 98 age- and sex-matched controls. Serum vitamin D was measured using ELISA, with deficiency defined as < 20 ng/ml. Cirrhosis severity was assessed using Child-Pugh and MELD scores. Spearman’s correlation was used to assess the relationship between vitamin D and severity of liver cirrhosis while ordinal regression analysis assessed its performance as an indicator of the disease severity. Result Among cirrhotic patients, 36.9% were deficient, 31.1% insufficient, and 32.0% had sufficient vitamin D levels. Serum vitamin D showed strong negative correlations with Child-Pugh and MELD scores (r = -0.696, p < 0.001; r = -0.734, p < 0.001, respectively). Ordinal regression showed that higher vitamin D levels were associated with lower severity scores (Child-Pugh: OR = 0.856, 95% CI: 0.815–0.900, p < 0.001; MELD: OR = 0.875, 95% CI: 0.837–0.915, p < 0.001). Conclusion Lower serum vitamin D levels correlated with increased liver cirrhosis severity, suggesting its potential as both a prognostic marker and therapeutic target. Further studies should investigate the efficacy of vitamin D supplementation in improving cirrhosis outcomes.

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The Declaration of Helsinki in bioethics literature since the last revision in 2013

Cited by 4 publications

References 3 publications

Catching the next wave? The relationship between UNESCO and developments in genomics

Catching the next wave? The relationship between UNESCO and developments in genomics

60th anniversary of the Declaration of Helsinki: ethical challenges in the 10th amendment

Association between serum vitamin D status and severity of liver cirrhosis: implications for therapeutic targeting in Nigerian patients

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