The dCas9-based genome editing in
Plasmodium yoelii
Chao Zhang,
Shijie Yang,
Elvis Quansah
et al.
Abstract:Genetic editing is a powerful tool for functional characterization of genes in various organisms. With its simplicity and specificity, the CRISPR-Cas9 technology has become a popular editing tool, which introduces site-specific DNA double-strand breaks (DSBs), and then leverages the endogenous repair pathway for DSB repair
via
homology-directed repair (HDR) or the more error-prone non-homologous end joining (NHEJ) pathways. However, in the
Plasmodium
para… Show more
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