The Daughter Of Time: Late Development Of Waldenstrom's Macroglobulinemia In A Patient With Immunotactoid Glomerulopathy.

Abstract

Immunotactoid glomerulopathy (ITG) is a rare cause of chronic kidney disease (CKD) and end-stage-renaldisease (ESRD). It is often associated with monoclonal gammopathy and/or hematologic malignancy. We report a patient originally diagnosed with ITG in 1998. He presented with nephrotic-range proteinuria, hypertension, and a gradual decline in glomerular filtration rate. A published case report of this patient at the time the disease was originally diagnosed described only a small peak of IgM paraprotein without lymphoma or plasma cell dyscrasia. He was diagnosed with monoclonal gammopathy of unknown significance. He later developed ESRD and initiated hemodialysis in 2004. Fourteen years after the diagnosis of ITG and MGUS was made he developed headache, lymphadenopathy, borderline splenomegaly, thrombocytopenia, and coagulopathy. Workup revealed a very high level of monoclonal IgM-kappa (4390 mg/dL),and low grade Bcell lymphoma, consistent with lymphoplasmacytic lymphoma, leading to a diagnosis of Waldenstrom's macroglobulinemia (WM). He died shortly thereafter of complicated gram-negative sepsis. To our knowledge this is the first report of WM associated with ITG. The patient's course illustrates that plasma cell dyscrasia and lymphoma can present many years after the original diagnosis of ITG is made and that continued vigilance for these conditions is warranted.

A rare case of MGRS with immunotactoid glomerulopathy responding to bortezomib, dexamethasone, and rituximab

“…Gabbay and colleagues described a 83-year-old male patient who was initially diagnosed with MGUS and ITG 14 years prior to the report. 10 He ultimately succumbed following progression of MGRS to WM and lymphoplasmacytic lymphoma. Given the evidence currently available in the literature, we assumed our patient to be at increased risk for progression to WM or ESRD and with her minimal burden of comorbidities; we determined that it was in her best interest to treat her disease aggressively to prevent these outcomes.…”

“…Typically, ITG is more closely associated with malignant conditions such as CLL, lymphoplasmacytic lymphoma, and multiple myeloma, 7 and to our knowledge, there has only been one other case report of ITG associated with IgM MGRS. Gabbay and colleagues described a 83‐year‐old male patient who was initially diagnosed with MGUS and ITG 14 years prior to the report 10 . He ultimately succumbed following progression of MGRS to WM and lymphoplasmacytic lymphoma.…”