Expectations or predictions about upcoming content play an important role during language comprehension and processing. Semantic similarity as a metric has been used to predict the experimental data on language comprehension and processing. Some approaches have been proposed to compute contextual semantic similarity to predict how words in a context are processed. However, these approaches can be improved. This study uses a massive and naturalistic discourse as stimuli for collecting data on eye-movement in reading. It proposes asimple but effective approach to computing contextual semantic similarity. In order to test the efficiency of the new approach, we compare it to the recently developed cosine method and the Euclidean method. This comparison reveals that our approach can make good predictions about fixation durations on reading and that it outperforms the two aforementioned approaches. To our knowledge, this is the first study to compare a number of approaches on contextual semantic similarity that are used to process naturalistic discourse in the fields of cogni-tion, psycholinguistics and neuroscience. The findings of this study aretherefore of significance to the acquisition of a better understanding ofhow humans process words in a real-world context and how they makepredictions in language comprehension and processing. This study creates an interpretable but more effective approach for computing contextual semantic similarity, which allows further explorations of the data on naturalistic discourse reading, language comprehension and neuroscience.