The dark side of dioxygen biochemistry

Valentine, Joan Selverstone; Wertz, Diana L.; Lyons, Thomas J.; Liou, Lee-Loung; Goto, Joy J.; Gralla, Edith Butler

doi:10.1016/s1367-5931(98)80067-7

Cited by 191 publications

(182 citation statements)

References 82 publications

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“…In these conditions, the cells endure a very high oxidative stress that leads to the cellular inactivation. While some authors have mentioned a catalytic role of the NPs in the formation of ROS, it has to be mentioned that these oxygen species are a natural by-product of the oxygenic respiration [34,35]. Scavenging mechanisms exists in the cell to lower their concentration, and reduce thus the oxidative stress.…”

Section: Role Of Agmentioning

confidence: 99%

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Antibacterial activity of silver nanoparticles: A surface science insight

2015

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Summary Silver nanoparticles constitute a very promising approach for the development of new antimicrobial systems. Nanoparticulate objects can bring significant improvements in the antibacterial activity of this element, through specific effect such as an adsorption at bacterial surfaces. However, the mechanism of action is essentially driven by the oxidative dissolution of the nanoparticles, as indicated by recent direct observations. The role of Ag + release in the action mechanism was also indirectly observed in numerous studies, and explains the sensitivity of the antimicrobial activity to the presence of some chemical species, notably halides and sulfides which form insoluble salts with Ag + . As such, surface properties of Ag nanoparticles have a crucial impact on their potency, as they influence both physical (aggregation, affinity for bacterial membrane, etc.) and chemical (dissolution, passivation, etc.) phenomena. Here, we review the main parameters that will affect the surface state of Ag NPs and their influence on antimicrobial efficacy. We also provide an analysis of several works on Ag NPs activity, observed through the scope of an oxidative Ag + release.

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Section: Role Of Agmentioning

confidence: 99%

“…ROS species are formed naturally by cells that present a respiratory activity, and contribute to the oxidative stress [35]. They can also be formed by photo-oxidation of water, in presence of a catalyst [43].…”

Section: Role Of Ag + Speciesmentioning

confidence: 99%

Antibacterial activity of silver nanoparticles: A surface science insight

2015

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“…, the one-electron reduction product of molecular oxygen, is a toxic by-product of oxygen metabolism (1,2). Fortunately, cells possess O 2 . detoxifying enzymes, which are essential to their survival in the presence of oxygen.…”

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confidence: 99%

“…The first one is the well known metalloenzyme superoxide dismutase (SOD), present in almost all aerobic cells (1,2 Although both systems produce H 2 O 2 , a toxic substance precursor of HO • radicals that needs to be eliminated by catalase or peroxidase enzymes, the elimination of O 2 . by SOD or SOR appears to be an essential cellular process to allow organisms to survive in the presence of O 2 (1,2,6). The SOR active site consists of a mononuclear ferrous ion in an unusual [Fe 2ϩ (N-His) 4 (S-Cys)] square pyramidal pentacoordination (7,8).…”

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confidence: 99%

Detoxification of superoxide without production of H ₂ O ₂ : Antioxidant activity of superoxide reductase complexed with ferrocyanide

Molina-Heredia

Houée-Levin⊥

Berthomieu

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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“…[1][2][3][4][5] This oxidative stress will cause endothelial lesion and will be responded by endothelial cells through nitric oxide (NO) response and immunological response pathway. 6-8 The immunological response begins by increasing cytokines production, activated coagulation factors, and reactivation of platelet in acute thrombotic process.…”

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confidence: 99%

Effect of Short-Term Low-Intensity Exercise Training on Association of Oxygen Free Radicals and Nitric Oxide Production in Patients with Acute Myocardial Infarction

et al. 2013

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Oxygen, although is highly required for living, can be toxic because it can be easily changed into oxygen free radicals (reactive oxygen species, ROS) and generates oxidative stress. [1][2][3][4][5] This oxidative stress will cause endothelial lesion and will be responded by endothelial cells through nitric oxide (NO) response and immunological response pathway. 6-8 The immunological response begins by increasing cytokines production, activated coagulation factors, and reactivation of platelet in acute thrombotic process. However, acute thrombotic process, which is an initial part of protective mechanism to fix the lesion, often change to become continuous process because of abundance oxidative stress, and then generates various levels of acute coronary syndromes. 3,5 Several studies showed that acute exercise on treadmill test with high intensity Bruce protocol increased oxidative stress because of ROS. 9,10 On the contrary, acute exercise also increased production of NO because of the increment effect of shear stress on endothelial cells. 6,9-15 But, regular exercise Keywords ► acute coronary syndrome ► atherosclerosis ► cardiovascular risk factors ► myocardial infarction ► oxidative stress ► nitric oxide ► cardiac markers ► exercise AbstractModerate-to-high intensity of exercise training within 2 to 3 months decreases oxygen free radicals (reactive oxygen species, ROS) and increases nitric oxide (NO) in outpatients with myocardial infarction. There is no data about the association of ROS and NO after short-term low-intensity exercise training within 5 days in patients hospitalized with acute myocardial infarction (AMI). A total of 32 male patients with AMI were randomized into two groups: 15 patients with short-term low-intensity exercise training within 5 days formed the training group and 17 patients without such exercise training formed the control group. All patients performed exercise treadmill test with modified Bruce protocol before and after the study. F2-isoprostane and NO concentration of the training group increased slightly after modified Bruce exercise treadmill test. Compared with the control group, NO of the training group was also slightly higher. Baseline NO and uric acid were negative predictor variables for F2-isoprostane in all patients hospitalized with AMI, and triglyceride was a positive predictor variable. After the study, physical capacity of the training group was higher; but heart rate and systolic blood pressure were lower significantly. This study showed that short-term low-intensity exercise training for patients hospitalized with AMI did not change ROS and NO productions, but it improved physical capacity and lowered heart rate and systolic blood pressure. NO was negative predictor variable for F2-isoprostane in controlling ROS changes in dynamic compensation mechanism.

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The dark side of dioxygen biochemistry

Cited by 191 publications

References 82 publications

Antibacterial activity of silver nanoparticles: A surface science insight

Antibacterial activity of silver nanoparticles: A surface science insight

Detoxification of superoxide without production of H ₂ O ₂ : Antioxidant activity of superoxide reductase complexed with ferrocyanide

Effect of Short-Term Low-Intensity Exercise Training on Association of Oxygen Free Radicals and Nitric Oxide Production in Patients with Acute Myocardial Infarction

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The dark side of dioxygen biochemistry

Cited by 191 publications

References 82 publications

Antibacterial activity of silver nanoparticles: A surface science insight

Antibacterial activity of silver nanoparticles: A surface science insight

Detoxification of superoxide without production of H 2 O 2 : Antioxidant activity of superoxide reductase complexed with ferrocyanide

Effect of Short-Term Low-Intensity Exercise Training on Association of Oxygen Free Radicals and Nitric Oxide Production in Patients with Acute Myocardial Infarction

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Detoxification of superoxide without production of H ₂ O ₂ : Antioxidant activity of superoxide reductase complexed with ferrocyanide