The Dark Side of an Essential Amino Acid: L-Arginine in Spinal Cord Injury

Erens, Céline; Broeckhoven, Jana Van; Bronckaers, Annelies; Lemmens, Stefanie; Hendrix, Sven

doi:10.1089/neu.2022.0271

Cited by 3 publications

(2 citation statements)

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“…l-arginine is an indispensable precursor of nitric oxide, which plays an essential role in angiogenesis and ATP homeostasis that promote neural cells and blood vessels proliferation and differentiation when it extends neural and vascular processes [71]. Additionally, l-arginine can induce neuroinflammation via the two key enzymes: nitric oxide synthase and arginase, which may lead to nerve system damage [71,72]. Histidine, as the precursor of carnosine, which acts as an antioxidant and scavenger of reactive oxygen species (ROS) [44,73,74], may also contribute to promoting oxidative stress in the placenta-brain axis of infants with sFGR.…”

Section: Discussionmentioning

confidence: 99%

Metabolic dynamics and prediction of sFGR and adverse fetal outcomes: a prospective longitudinal cohort study

Huang,

Chen,

Jiang

et al. 2023

BMC Med

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Background Selective fetal growth restriction (sFGR) is an extreme complication that significantly increases the risk of perinatal mortality and long-term adverse neurological outcomes in offspring, affecting approximately 15% of monochorionic diamniotic (MCDA) twin pregnancies. The lack of longitudinal cohort studies hinders the early prediction and intervention of sFGR. Methods We constructed a prospective longitudinal cohort study of sFGR, and quantified 25 key metabolites in 337 samples from maternal plasma in the first, second, and third trimester and from cord plasma. In particular, our study examined fetal growth and brain injury data from ultrasonography and used the Ages and Stages Questionnaire-third edition subscale (ASQ-3) to evaluate the long-term neurocognitive behavioral development of infants aged 2–3 years. Furthermore, we correlated metabolite levels with ultrasound data, including physical development and brain injury indicators, and ASQ-3 data using Spearman’s-based correlation tests. In addition, special combinations of differential metabolites were used to construct predictive models for the occurrence of sFGR and fetal brain injury. Results Our findings revealed various dynamic patterns for these metabolites during pregnancy and a maximum of differential metabolites between sFGR and MCDA in the second trimester (n = 8). The combination of l-phenylalanine, l-leucine, and l-isoleucine in the second trimester, which were closely related to fetal growth indicators, was highly predictive of sFGR occurrence (area under the curve [AUC]: 0.878). The combination of l-serine, l-histidine, and l-arginine in the first trimester and creatinine in the second trimester was correlated with long-term neurocognitive behavioral development and showed the capacity to identify fetal brain injury with high accuracy (AUC: 0.94). Conclusions The performance of maternal plasma metabolites from the first and second trimester is superior to those from the third trimester and cord plasma in discerning sFGR and fetal brain injury. These metabolites may serve as useful biomarkers for early prediction and promising targets for early intervention in clinical settings.

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Section: Discussionmentioning

confidence: 99%

Metabolic dynamics and prediction of sFGR and adverse fetal outcomes: a prospective longitudinal cohort study

Huang,

Chen,

Jiang

et al. 2023

BMC Med

View full text Add to dashboard Cite

show abstract

“…Although arginine is necessary for function of neuronal cells, it also causes neuroinflammation and NO production. A consequence of latter is that arginine depletion actually helps spinal cord regeneration after an injury [173]. Furthermore, recent metabonomic-based analysis identified arginine in plasma as a key biomarker among the 85 differentials metabolites identified between the chronic obstructive pulmonary disease (COPD) patients and healthy people [174].…”

Section: Metabolic Importance Of Argininementioning

confidence: 99%