Abstract:Signatures of DNA motifs associated with distinct mutagenic exposures have been defined for somatic variants, but little is known about the consequences different mutational processes pose to the cancer cell, particularly the distribution of the resulting variants in the implied proteins and their structural regions (surface, core, interacting interface). Here we first compare the protein-level consequences of six mutational signatures (Aging, APOBEC, POLE, UV, 5-FU and Platinum) characterised by clear DNA mot… Show more
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