The Danish Testicular Cancer database

Abstract

AimThe nationwide Danish Testicular Cancer database consists of a retrospective research database (DaTeCa database) and a prospective clinical database (Danish Multidisciplinary Cancer Group [DMCG] DaTeCa database). The aim is to improve the quality of care for patients with testicular cancer (TC) in Denmark, that is, by identifying risk factors for relapse, toxicity related to treatment, and focusing on late effects.Study populationAll Danish male patients with a histologically verified germ cell cancer diagnosis in the Danish Pathology Registry are included in the DaTeCa databases. Data collection has been performed from 1984 to 2007 and from 2013 onward, respectively.Main variables and descriptive dataThe retrospective DaTeCa database contains detailed information with more than 300 variables related to histology, stage, treatment, relapses, pathology, tumor markers, kidney function, lung function, etc. A questionnaire related to late effects has been conducted, which includes questions regarding social relationships, life situation, general health status, family background, diseases, symptoms, use of medication, marital status, psychosocial issues, fertility, and sexuality. TC survivors alive on October 2014 were invited to fill in this questionnaire including 160 validated questions. Collection of questionnaires is still ongoing. A biobank including blood/sputum samples for future genetic analyses has been established. Both samples related to DaTeCa and DMCG DaTeCa database are included. The prospective DMCG DaTeCa database includes variables regarding histology, stage, prognostic group, and treatment.ConclusionThe DMCG DaTeCa database has existed since 2013 and is a young clinical database. It is necessary to extend the data collection in the prospective database in order to answer quality-related questions. Data from the retrospective database will be added to the prospective data. This will result in a large and very comprehensive database for future studies on TC patients.

Sexual Function in a Nationwide Cohort of 2,260 Survivors of Testicular Cancer after 17 Years of Followup

“…Between 2014-2016 we conducted a questionnaire survey evaluating patient reported outcomes in Danish TCS with a median follow-up of 17 years after diagnosis (DaTeCa-LATE) 5 . All Danish TCS included in the national DaTeCa database (TC patients treated from 1984-2007) 6 were invited, and of 4271 eligible TCS, 2572 (60%) filled in the 167-item questionnaire. Detailed information about the design of DaTeCa-LATE can be found elsewhere 5 .…”

Prognostic factors for relapse in patients with clinical stage I testicular cancer: protocol for a Danish nationwide cohort study

“…Data are obtained from the prospective Danish Testicular Cancer (DaTeCa) database32 and linkage of the DaTeCa database to the following national registries: the Danish Pathology Registry (DPR),33 34 the Danish National Patient Registry (DNPR)35 and the Danish Civil Registration System (CRS),36 as specified in table 1. Individual-level linkage of data is possible due to a unique civil personal 10-digit registration number (Danish civil registration number, CPR), assigned to all Danish citizens at birth or immigration, which is recorded along with administrative and medical information in registries and databases 36 37…”

“…The nationwide clinical database holds information of all incident germ cell cancers (GCCs) in males aged ≥15 years of both gonadal and extragonadal origin in Denmark from 2013 onward 32. The database contains prospectively collected clinical data registered by the treating physicians at the oncological departments by using standardised case report forms, as previously described,32 including information on clinical stage, relapse data and preorchiectomy values of STMs (AFP, hCG and LDH) used for this study. The database is linked to the DPR and the DNPR to ensure completeness of the identification of all incident TGCC cases as well as of the reporting to the database, table 1.…”

Histopathological pattern of testicular diseases in western Saudi Arabia

“…Scientists from London, analyzing the global incidence of testicular cancer have reported its incidence rate to be highest in New Zealand and lowest in India 32. Researcher from Denmark found testicular cancer to be a rare disease, with approximately 300 cases per year in their whole country, although it was the most common cancer in men aged 20 to 40 years 33. Similarly, Assi et al6 from Lebanon report a mean age of 32 years in their testicular tumor patients.…”