The Danish Psychiatric Central Research Register

Context: Prenatal infection and traumatizing experiences have both been linked with schizophrenia, but none of these factors seem sufficient to cause the disorder. However, recent evidence suggests that these environmental insults act in synergy to increase schizophrenia risk. Objective: To estimate the independent and joint effects of exposure to prenatal infection and peripubertal psychological trauma on the risk of schizophrenia. Design: Danish nationwide registers were linked in this prospective cohort study. We used survival analysis to report incidence rate ratios (IRRs) and corresponding 95% confidence intervals (95% CIs). Analyses were adjusted for age and calendar period and stratified by sex. Participants: A total of 979 701 persons born between 1980 and 1998 were followed up from January 1, 1995 through December 31, 2013, with 9656 having a hospital contact for schizophrenia. Results: Females exposed to prenatal infection had a significantly increased risk of schizophrenia (IRR: 1.61, 95% CI: 1.30-2.00), but not males (IRR: 0.99, 95% CI: 0.77-1.28). Peripubertal trauma was associated with increased risk in both sexes. Males, however, had a significantly higher risk of schizophrenia after exposure to both prenatal infection and peripubertal psychological trauma (IRR: 2.85, 95% CI: 2.32-3.51), with significant interaction between infection and peripubertal trauma on the multiplicative scale (P = .007). Conclusions: Our study demonstrated for the first time that prenatal infection and psychological trauma in peripubertal life can act in synergy to increase the risk of schizophrenia, with a potentially stronger susceptibility in males.

show abstract

“…It covers all psychiatric inpatient facilities in Denmark since 1969 and all outpatient contacts since 1994. 29 …”

Section: Data Sourcesmentioning

confidence: 99%

Joint Effects of Exposure to Prenatal Infection and Peripubertal Psychological Trauma in Schizophrenia

Debost

Larsen

Munk‐Olsen

et al. 2016

Schizophrenia Bulletin

Self Cite

View full text Add to dashboard Cite

show abstract

“…the psychiatric disease incidence from the Danish Psychiatric Central Research Register [7] over nationwide clinical databases [8] to information on social and economic issues, e.g. information on income and income transfers [9].…”

Section: Examples Of Danish Registers Containing Social-and Health-rementioning

confidence: 99%

Introduction to Danish (nationwide) registers on health and social issues: Structure, access, legislation, and archiving

Thygesen

Daasnes

Thaulow

et al. 2011

Scand J Public Health

865

817

View full text Add to dashboard Cite

Danish registers contain information on many important health and social issues. Because all Danish citizens have a unique personal identification number, linkage at the individual level between these nationwide registers and other data sources is possible and feasible. In this paper we briefly introduce selected Danish registers and the data structure and requirements for getting access to data at Statistics Denmark, which is the main provider of register data. We introduce the Danish Data Archive and briefly present the Act on Processing of Personal Data, which is the legal foundation for analyses of registerbased data in Denmark.

show abstract

“…Data on background variables has been obtained from Statistics Denmark. Data has also been obtained from the Psychiatric Central Research Register (Mors et al, 2011) and from the Register of Treatment for Substance Addiction, which has been provided by from Statens Serum Institut, a public agency under the Danish Ministry of Health. Mental illness, alcohol or drug abuse problems, and imprisonment are measured from 1994 to 2009.…”

Section: Datamentioning

confidence: 99%

Testing a Typology of Homelessness Across Welfare Regimes: Shelter Use in Denmark and the USA

Benjaminsen

Andrade

2015

Housing Studies

View full text Add to dashboard Cite

This article compares patterns of homeless shelter use in Denmark and the USA. Combining data from homeless shelters in Denmark with population registers, we find that the prevalence of shelter use is substantially lower in Denmark than in the USA. A cluster analysis of shelter stays identifies three types of users similar to findings from US research: the transitionally, episodically and chronically homeless. However, the transitionally homeless in Denmark have a higher tendency of suffering from mental illness and substance abuse than the transitionally homeless in the USA. The results support Stephens and Fitzpatrick' hypothesis that countries with more extensive welfare systems and lower levels of poverty have lower levels of homelessness, mainly amongst those with complex support needs, whereas in countries with less extensive welfare systems homelessness affects broader groups and is more widely associated with poverty and housing affordability problems.

show abstract

The Danish Psychiatric Central Research Register

Cited by 1,303 publications

References 7 publications

Joint Effects of Exposure to Prenatal Infection and Peripubertal Psychological Trauma in Schizophrenia

Joint Effects of Exposure to Prenatal Infection and Peripubertal Psychological Trauma in Schizophrenia

Introduction to Danish (nationwide) registers on health and social issues: Structure, access, legislation, and archiving

Testing a Typology of Homelessness Across Welfare Regimes: Shelter Use in Denmark and the USA

Contact Info

Product

Resources

About