The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health

BackgroundObesity may increase heart failure risk through cardiac remodeling. Cross‐sectional associations between adiposity and cardiac structure and function have been elucidated, but the impact of longitudinal changes in adiposity on cardiac remodeling is less well understood.Methods and ResultsParticipants in the Dallas Heart Study without cardiovascular disease or left ventricular dysfunction underwent assessment of body weight, anthropometrics, and cardiac magnetic resonance imaging at baseline and 7 years later. Associations between changes in indices of generalized and central adiposity with changes in left ventricular mass, volume, mass/volume ratio (concentricity), wall thickness, and ejection fraction were assessed using multivariable linear regression. The study cohort (n=1262) mean age was 44 years with 57% women, 44% black, and 36% obese participants. At follow‐up, 41% had ≥5% weight gain, and 15% had ≥5% weight loss. Greater weight gain was associated with younger age, lower risk factor burden, and lower body mass index at baseline. In multivariable models adjusting for age, sex, race, comorbid conditions at baseline and follow‐up, baseline adiposity, and cardiac measurement, increasing weight was associated with increases in left ventricular mass (β=0.10, P<0.0001), wall thickness (β=0.10, P<0.0001), and concentricity (β=0.06, P=0.002), with modest effects on end‐diastolic volume (β=0.04, P=0.044) and ejection fraction (β=0.05, P=0.046). Similar results were seen with other adiposity indices.ConclusionsConcentric left ventricular remodeling is the predominant phenotype linked to increasing adiposity in middle age. Our findings support the importance of weight management to prevent secular changes in adiposity, concentric remodeling, and eventual heart failure over time.

show abstract

“…Detailed methods of the DHS have been described previously 19. A participant flow diagram for the current study is provided in Figure 1.…”

Section: Methodsmentioning

confidence: 99%

Dynamic Relation of Changes in Weight and Indices of Fat Distribution With Cardiac Structure and Function: The Dallas Heart Study

Wilner

Garg

Ayers

et al. 2017

JAHA

View full text Add to dashboard Cite

show abstract

“…The DHS is a population-based probability sample of Dallas County (52% African American, self-identified as 'black'; 29% European American, selfidentified as 'white'; 17% Hispanic and 2% other ethnicities) in which ethnicity was self assigned according to US census categories 9 . The study was approved by the institutional review board of University of Texas Southwestern Medical Center, and all subjects provided written informed consent before participation.…”

Section: Study Populationsmentioning

confidence: 99%

“…To determine how sequence variations in ANGPTL4 influence energy metabolism in humans, we sequenced the seven exons and the intron-exon boundaries of the gene (Supplementary Table 1 online) in 3,551 participants in the Dallas Heart Study, a population-based probability sample of Dallas County residents (1,830 African American, 601 Hispanic, 1,045 European American and 75 other ethnicities) whose lipid and glucose metabolism has been characterized in detail 9,10 . We identified a total of 93 sequence variations (65 in African Americans, 45 in European Americans and 31 in Hispanics), most of which were rare: more than half (n = 49) were found only in one subject, and 86% (n = 80) had a minor allele frequency below 3% (Supplementary Fig.…”

mentioning

confidence: 99%

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL

et al. 2007

Self Cite

View full text Add to dashboard Cite

Resequencing genes provides the opportunity to assess the full spectrum of variants that influence complex traits. Here we report the first application of resequencing to a large population (n = 3,551) to examine the role of the adipokine ANGPTL4 in lipid metabolism. Nonsynonymous variants in ANGPTL4 were more prevalent in individuals with triglyceride levels in the lowest quartile than in individuals with levels in the highest quartile (P = 0.016). One variant (E40K), present in ~3% of European Americans, was associated with significantly lower plasma levels of triglyceride and higher levels of high-density lipoprotein cholesterol in European Americans from the Atherosclerosis Risk in Communities Study and in Danes from the Copenhagen City Heart Study. The ratio of nonsynonymous to synonymous variants was higher in European Americans than in African Americans (4:1 versus 1.3:1), suggesting population-specific relaxation of purifying selection. Thus, resequencing of ANGPTL4 in a multiethnic population allowed analysis of the phenotypic effects of both rare and common variants while taking advantage of genetic variation arising from ethnic differences in population history.Adipocytes secrete a variety of proteins that regulate glucose and lipid metabolism 1 . The metabolic effects of these proteins have been largely deduced from studies in mice; less is Correspondence should be addressed to H.H. (helen.hobbs@utsouthwestern.edu) or J.C.C. (jonathan.cohen@utsouthwestern.edu). 7 These authors contributed equally to this work.Note: Supplementary information is available on the Nature Genetics website.Reprints and permissions information is available online at http://npg.nature.com/reprintsandpermissions COMPETING INTERESTS STATEMENTThe authors declare that they have no competing financial interests. , most of which were rare: more than half (n = 49) were found only in one subject, and 86% (n = 80) had a minor allele frequency below 3% (Supplementary Fig. 1 and Supplementary Table 2 online). NIH Public AccessTo examine the phenotypic effects of sequence variation in ANGPTL4, we stratified the population by race, sex and trait level and then compared the number of nonsynonymous variants in the top and bottom quartiles of the distribution. We excluded variants found in both quartiles. The first trait we examined was fasting levels of plasma triglyceride. Individuals with factors known to affect triglyceride levels (lipid-lowering drugs, diabetes mellitus and heavy alcohol use) were excluded from the analyses. After these exclusions, the number of individuals with nonsynonymous sequence variants in the bottom quartile (n = 13) was significantly greater than the number in the highest quartile (n = 2; P = 0.016) (Fig. 1); we found all sequence variations in separate individuals except R336C, which was present in three European Americans in the lowest quartile of triglycerides. Although European Americans comprised less than one-third of the sample (1,045 out of 3,551), 10 of the 13 individuals with a nonsynonymou...

show abstract

“…The Dallas Heart study cohort is a multi-ethnic populationbased probability sample of the Dallas County. The study design and methodology is described elsewhere (17). In summary, the study consisted of three sequential phases, including two home visits, and a clinical visit.…”

Section: Study Populationmentioning

confidence: 99%

Agreement between methods of measurement of mean aortic wall thickness by MRI

Rosero

Peshock

Khera

et al. 2009

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: To assess the agreement between three methods of calculation of mean aortic wall thickness (MAWT) using magnetic resonance imaging (MRI). Materials and Methods:High-resolution MRI of the infrarenal abdominal aorta was performed on 70 subjects with a history of coronary artery disease who were part of a multiethnic population-based sample. MAWT was calculated as the mean distance between the adventitial and luminal aortic boundaries using three different methods: average distance at four standard positions (AWT-4P), average distance at 100 automated positions (AWT-100P), and using a mathematical computation derived from the total vessel and luminal areas (AWT-VA). Bland-Altman plots and Passing-Bablok regression analyses were used to assess agreement between methods. Results:Bland-Altman analyses demonstrated a positive bias of 3.02 Ϯ 7.31% between the AWT-VA and the AWT-4P methods, and of 1.76 Ϯ 6.82% between the AWT-100P and the AWT-4P methods. Passing-Bablok regression analyses demonstrated constant bias between the AWT-4P method and the other two methods. Proportional bias was, however, not evident among the three methods. Conclusion:MRI methods of measurement of MAWT using a limited number of positions of the aortic wall systematically underestimate the MAWT value compared with the method that calculates MAWT from the vessel areas.

show abstract

The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health

Cited by 479 publications

References 17 publications

Dynamic Relation of Changes in Weight and Indices of Fat Distribution With Cardiac Structure and Function: The Dallas Heart Study

Dynamic Relation of Changes in Weight and Indices of Fat Distribution With Cardiac Structure and Function: The Dallas Heart Study

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL

Agreement between methods of measurement of mean aortic wall thickness by MRI

Contact Info

Product

Resources

About