The D‐vitamin metabolite 1,25(<scp>OH</scp>)<sub>2</sub>D in serum is associated with disease activity and Anti‐Citrullinated Protein Antibodies in active and treatment naïve, early Rheumatoid Arthritis Patients

Herly, M.; Stengaard‐Pedersen, Kristian; Vestergaard, Peter; Østergaard, Mikkel; Junker, Peter; Hetland, Merete Lund; Hørslev‐Petersen, Kim; Ellingsen, Torkell

doi:10.1111/sji.12704

Cited by 19 publications

(19 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, numerous studies revealed that single nucleotide polymorphisms (SNPs) of HLA-DRB1 (40–46), STAT4 (47–52), and vitamin D receptor ( VDR ) (53–58) were associated with RA and AITD. Scientists also observed that smoking and vitamin D deficiency had strong association with RA and AITD (59–61). Furthermore, some researchers found that similar immune dysregulation appears in both RA and AITD.…”

Section: Discussionmentioning

confidence: 99%

Increased Risk of Thyroid Dysfunction Among Patients With Rheumatoid Arthritis

Wang

et al. 2019

Front. Endocrinol.

View full text Add to dashboard Cite

Background: Thyroid dysfunction seems to be common among rheumatoid arthritis (RA) patients, but the risk of thyroid dysfunction in RA has not been well-defined. Methods:We performed a case-control study of 65 RA patients and 550 matched non-RA subjects to assess the risk of thyroid dysfunction among Chinese RA patients. A systematic review and meta-analysis was also conducted to comprehensively define the relationship between RA and thyroid dysfunction. Results:The case-control study indicated that the prevalence of thyroid dysfunction was significantly higher in RA patients than controls (OR = 2.89, P < 0.001). Further subgroup analyses revealed positive correlations of RA with hypothyroidism (OR = 2.28, P = 0.006) and hyperthyroidism (OR = 8.95, P < 0.001). Multivariate logistic regression analysis revealed an independent association between RA and thyroid dysfunction (Adjusted OR = 2.89, 95%CI 1.63-5.12, P < 0.001). Meta-analysis of 15 independent studies also showed an obviously increased risk of thyroid dysfunction among RA patients (RR = 2.86, 95%CI 1.78-4.58, P < 0.001). Further subgroup analysis showed RA could obviously increase risk of hyperthyroidism (RR = 2.73, 95%CI 1.29-5.77, P = 0.043) and hypothyroidism (RR = 2.02, 95%CI 1.49-2.74, P < 0.001). Conclusion:Our study provides strong evidence for the increased risk of thyroid dysfunction among RA patients. Screening of thyroid dysfunction may be recommended for RA patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased Risk of Thyroid Dysfunction Among Patients With Rheumatoid Arthritis

Wang

et al. 2019

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…In 2015, Cooles et al reported no relationship between 25OHD and CRP, ESR, symptom duration, tender joint count (TJC), swollen joint count (SJC), or patients' global health visual analogue scale (GH-VAS) in a small cohort of 73 RA patients [13], and similarly Neilen et al found no evidence of low vitamin D in blood donor samples from patients in the pre-RA phase [14]. Conversely, other studies have reported an association of serum 25OHD or 1,25(OH) 2 D status with some markers of disease activity in early RA [15,16].…”

Section: Introductionmentioning

confidence: 96%

Vitamin D and early rheumatoid arthritis

Harrison

Jutley

et al. 2020

BMC Rheumatol

View full text Add to dashboard Cite

Background: Previous studies have linked rheumatoid arthritis (RA) risk and disease activity with vitamin D-deficiency (low serum 25-hydroxyvitamin D (25OHD)), but a causal role for vitamin D in RA is still unclear, with conflicting results from many previous studies, partly due to heterogeneity in study design and patient populations. In this study we aimed to (1) analyse serum 25OHD in early inflammatory arthritis, (2) compare 25OHD with disease activity and fatigue in early RA and (3) determine whether low 25OHD is associated with progression to RA. Methods: An analysis of 790 patients recruited to the Birmingham Early Inflammatory Arthritis Cohort and followed longitudinally to determine clinical outcomes. The following were recorded at baseline: demographic data, duration of symptoms, duration of early morning stiffness (EMS), tender and swollen joint counts, Visual Analogue Scale (VAS) pain/ fatigue/EMS, PHQ-9, HAQ and FACIT-Fatigue scores, DAS28-ESR, DAS28-CRP, CRP, ESR, anti-CCP antibody status, rheumatoid factor status, and serum 25OHD (ng/ml). Diagnosis was recorded at 0 and 12 months onwards as either RA, Undifferentiated Inflammatory Arthritis (UIA; synovitis not meeting other classification/diagnostic criteria), Clinically Suspect Arthralgia (CSA; arthralgia of an inflammatory type without synovitis), or Other. Results: Baseline demographic data were similar between all groups, with median symptom duration of 16.8-34.0 days. Baseline 25OHD was not significantly different between groups [median, interquartile range (IQR): RA 46.7, 30.0-73.3; UIA 51.4, 30.0-72.3; CSA 47.7, 30.3-73.0; Other 39.9, 28.6-62.2]. In RA (n = 335), there were no significant differences between 25OHD and measures of disease activity or fatigue. No association between 25OHD and progression from UIA or CSA to RA was observed. Conclusions: There was no clear association between serum 25OHD and baseline diagnosis, RA disease activity, or progression from UIA or CSA to RA. Future studies of other vitamin D metabolites may better define the complex role of vitamin D in RA.

show abstract

“…9 Organ-specific disorders typically aggregate within the same individual in autoimmune polyendocrine syndromes (APS), 10 which are yet distinct from systemic autoimmune conditions such as rheumatoid arthritis (RA) or systemic lupus erythematous (SLE). [11][12][13] Symptoms of AAD can be vague, and as a result, the disease is often diagnosed after the complete destruction of the adrenal cortex. 14 This, and restricted access to the affected organ in these patients, limits our knowledge of immunological processes occurring in the development of the disease.…”

Section: Introductionmentioning

confidence: 99%