The D allele of angiotensin-converting enzyme gene is associated with a worse autonomic heart control in community-based older adults

Santos, Juleno Honorato Brito dos; Passos, R.S.; Freire, Ivna Vidal; Ribeiro, Ícaro José Santos; Oliveira, Alinne Alves; Casotti, Cézar Augusto; Alkahtani, Shaea; Barbosa, Ana Angélica Leal; Pereira, Rafael

doi:10.1016/j.exger.2021.111227

Cited by 4 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data obtained along the TT-test indicated a progressive increase of the parameter V2, achieving higher values at CAF supplementation (PC and CC), when compared to placebo. These find suggest a progressive increase of an indicator of parasympathetic activity 17 .…”

Section: Discussionmentioning

confidence: 72%

“…The R-R dynamics were classified into three pattern families: (I) patterns with no variation (V0; all three symbols were equal); (II) patterns with one variation (V1; two consequent symbols were equal, and the remaining symbol was different); and (III) patterns with two unlike or like variations (V2; all of the symbols were different from the previous ones). The percentage of the patterns V0 was calculated as sympathetic modulation predominance, V1 reflects sympathetic and parasympathetic modulation, and the V2 calculated as a parasympathetic modulation as suggested by Santos et al 17 . The data (i.e., successive RR intervals) were transferred to a computer for analysis.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies 15 , 16 investigated the impact of CAF on ANS through HRV, reporting HRV decrease with some doses, while different strategies could increase the HRV. Methodological aspects could explain divergent results, especially owing to complex HRV behavior during exercise, which could be minimized with appropriate mathematical methods to extract RR interval variability, as with non-linear methods 17 . Notwithstanding, lack of pattern of supplementation approach, including dose and selected strategy, also contribute to divergence in the issue of this study.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Caffeine increases performance and leads to a cardioprotective effect during intense exercise in cyclists

Sampaio-Jorge

Morales

Pereira

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

The present study was designed to investigate the effects of different caffeine dietary strategies to compare the impact on athletic performance and cardiac autonomic response. The order of the supplementation was randomly assigned: placebo(4-day)-placebo(acute)/PP, placebo(4-day)-caffeine(acute)/PC and caffeine(4-day)-caffeine(acute)/CC. Fourteen male recreationally-trained cyclists ingested capsules containing either placebo or caffeine (6 mg kg−1) for 4 days. On day 5 (acute), capsules containing placebo or caffeine (6 mg kg−1) were ingested 60 min before completing a 16 km time-trial (simulated cycling). CC and PC showed improvements in time (CC vs PP, Δ − 39.3 s and PC vs PP, Δ − 43.4 s; P = 0.00; ƞ2 = 0.33) and in output power (CC vs PP, Δ 5.55 w and PC vs PP, Δ 6.17 w; P = 0.00; ƞ2 = 0.30). At the final of the time-trial, CC and PC exhibited greater parasympathetic modulation (vagal tone) when compared to the PP condition (P < 0.00; ƞ2 = 0.92). Our study provided evidence that acute caffeine intake (6 mg∙kg−1) increased performance (time-trial) and demonstrated a relevant cardioprotective effect, through increased vagal tone.

show abstract

Section: Discussionmentioning

confidence: 72%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Caffeine increases performance and leads to a cardioprotective effect during intense exercise in cyclists

Sampaio-Jorge

Morales

Pereira

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, family members have a similar level of ACE plasma, suggesting that the inter individual variability in the ACE plasma level is determined by genetic factors (Ahmad Yuso & Che Muhamed ,2021). Among several polymorphisms of the ACE gene, the ACE I/D gene polymorphism has a strong association with the ACE plasma level, which accounts for 47% of the overall phenotypic variance of the ACE activity (Dos Santos et al,2021) .…”

Section: Introductionmentioning

confidence: 99%

Effect of ACE I/D polymorphism in cardiovascular disease patients

Al-Bayati

Al-Nahi

2022

ijhs

View full text Add to dashboard Cite

Cardiovascular diseases (CVD) are the cause of the highest mortality rate among noncommunicable diseases, Some of the main risk factors for CVD include smoking, hypertension, high body mass index, lipid metabolism disorders, and diabetes mellitus, according to emerging evidence, Genetics and polymorphisms are thought to play an important role in the occurrence and progression of CVD. A number of 100 subjects were involved in this investigation, 70 of them with CVDs and the other 30 healthy individuals were used as control. The study was conducted to find out the importance of ACE gene polymorphism and biochemical variables in CVDs patients. In addition, the study aimed to investigate the effect of gene polymorphism on CVDs. The comparisons between genotypic frequency of ACE gene polymorphism in control and CVDs patients showed a significant increase (p≤0.005) in DD, ID genotype in CVDs patients compared to control , where II genotype significant decreased in CVDs patients compared to control. Our results show insertion mutation at 550bp only in CVDs patients, this mutation not show in other research.

show abstract

Renin-angiotensin

Arnold¹,

Diz²

2023

Primer on the Autonomic Nervous System

View full text Add to dashboard Cite

The D allele of angiotensin-converting enzyme gene is associated with a worse autonomic heart control in community-based older adults

Cited by 4 publications

References 40 publications

Caffeine increases performance and leads to a cardioprotective effect during intense exercise in cyclists

Caffeine increases performance and leads to a cardioprotective effect during intense exercise in cyclists

Effect of ACE I/D polymorphism in cardiovascular disease patients

Renin-angiotensin

Contact Info

Product

Resources

About