The cytotoxicity of water-soluble carbon nanotubes on human embryonic kidney and liver cancer cells

Shiratsuchi, Yu; Su, Xudong; Du, Jinglei; Wang, Junli; Gao, Yuduan; Zhang, Li; Chen, Lin; Yang, Yongzhen; Liu, Xuguang

doi:10.1016/s1872-5805(18)60325-7

Cited by 23 publications

(4 citation statements)

References 15 publications

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“…Apart from the respiratory tract, it has been shown that CNTs can exhibit toxic effects on the other organs and systems such as reproduction [174,175], nervous system [176,177], liver [178,179], and kidneys [179,180].…”

Section: Toxicity Studies Of Carbon Nanotubesmentioning

confidence: 99%

The Advances in Biomedical Applications of Carbon Nanotubes

Saliev

2019

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Unique chemical, physical, and biological features of carbon nanotubes make them an ideal candidate for myriad applications in industry and biomedicine. Carbon nanotubes have excellent electrical and thermal conductivity, high biocompatibility, flexibility, resistance to corrosion, nano-size, and a high surface area, which can be tailored and functionalized on demand. This review discusses the progress and main fields of bio-medical applications of carbon nanotubes based on recently-published reports. It encompasses the synthesis of carbon nanotubes and their application for bio-sensing, cancer treatment, hyperthermia induction, antibacterial therapy, and tissue engineering. Other areas of carbon nanotube applications were out of the scope of this review. Special attention has been paid to the problem of the toxicity of carbon nanotubes.

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Section: Toxicity Studies Of Carbon Nanotubesmentioning

confidence: 99%

The Advances in Biomedical Applications of Carbon Nanotubes

Saliev

2019

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“…Although pristine SWNTs have been reported to have the capability of transporting their cargo without metabolism in the circulatory system and directly entering into the intracellular medium, − several studies revealed that carbon nanotubes have cytotoxic effects on cultured cells and adverse health outcomes on animals. Inhibition of cell proliferation, , induction of oxidative stress, , and apoptosis/necrosis are some of the negative impacts of carbon nanotubes. The toughest task in the employment of pristine SWNTs is their limited solubility in any biological environment due to their hydrophobic structure, which is prone to form bundles.…”

Section: Introductionmentioning

confidence: 99%

Noncovalent Pyrene-Polyethylene Glycol Coatings of Carbon Nanotubes Achieve in Vitro Biocompatibility

et al. 2018

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Single-walled carbon nanotubes (SWNTs) have become increasingly exploited in biological applications, such as imaging and drug delivery. The application of SWNTs in biological settings requires the surface chemistry to remain through the low solubility in aqueous media. In this research, a facile approach for the preparation of a polyethylene glycol (PEG)-coated SWNT-based nanocarrier was reported. We focused on the effect of PEG chain length and SWNT size on the cytotoxicity of PEG-coated SWNTs as a superior drug delivery nanovector. First, all-atom molecular dynamics (MD) simulations were employed to explore the stability and behavior of SWNT/pyrene-PEG (SWNT/Pyr-PEG) structures at a molecular level that is not attainable with experiments. The MD studies revealed that (i) π-π stacking interactions between the pyrene bearing PEG molecules and SWNTs are maintained in bulky situations, regardless of PEG molecular weight or SWNT size; (ii) pyrene molecules diffuse over the SWNT surface without detaching; and (iii) both short and long dynamic Pyr-PEG chains have the capability of effectively coating the SWNT surface. In light of the simulations, noncovalent (π-π stacking) assemblies of SWNT/Pyr-PEG with different molecular weights of PEG ( M = 2000, 5000, and 12000) were successfully fabricated and characterized. For longer PEG chains, more effective coating of SWNTs was obtained, resulting in more biocompatible SWNT/Pyr-PEG nanomaterials. The number of SWNTs coated by Pyr-PEG was highly dependent on the length of pyrene bearing PEG polymers. Moreover, the short SWNTs showed a higher amount of PEG coating with respect to the long SWNTs. Cell viability results demonstrated a dose-dependent cytotoxicity of coated SWNTs. Short SWNTs coated with longer PEG chains have low cytotoxicity to be used in in vivo studies.

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“…The CNTs hollow structure and large specific surface area facilitates the accommodation of biomolecules and drug molecules. However, they produce in vitro toxicity and immunogenicity in the body due to its inherent insolubility in physiological buffer . Particularly, APTES‐functionalized surfaces have been shown to be nontoxic to embryonic rat cardiomyocytes in vitro .…”

Section: Resultsmentioning

confidence: 99%

Solubility of aminotriethylene glycol functionalized single wall carbon nanotubes: A density functional based tight binding molecular dynamics study

Mananghaya

Santos

2019

J Comput Chem

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Pristine CNTs are exemplary hydrophobic solutes; properly functionalized CNTs can be seen as hydrophilic ones. The solubility of aminotriethylene glycol (ATG) functionalized single walled carbon nanotubes (fSWCNTs) were examined using density functional based tight binding method. According to the dynamics study, the ATG-fSWCNTs interaction energies (IE) and diffusion coefficients (D) are diameter dependent. As the diameter of the (n,0) tube is incrementally increased, a distinguishable pattern is observed, specifically the IE of the ATG-fSWCNT in water is quite higher for n that is an integral multiple of three (n = 9,12,15) while the D is lower due to its π bonding structures. In general, the metallic ATG functionalized nanotube possess a higher IE and a much lower D in aqueous media.

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The cytotoxicity of water-soluble carbon nanotubes on human embryonic kidney and liver cancer cells

Cited by 23 publications

References 15 publications

The Advances in Biomedical Applications of Carbon Nanotubes

The Advances in Biomedical Applications of Carbon Nanotubes

Noncovalent Pyrene-Polyethylene Glycol Coatings of Carbon Nanotubes Achieve in Vitro Biocompatibility

Solubility of aminotriethylene glycol functionalized single wall carbon nanotubes: A density functional based tight binding molecular dynamics study

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