The cytotoxicity of N-pyridinyl and N-quinolinyl substituted derivatives of phthalimide and succinimide

Palladium-Catalyzed One-Step Synthesis of Isoindole-1,3-diones by Carbonylative Cyclization of o-Halobenzoates and Primary Amines

“…10 Some isoindole-1,3-dione derivatives are active in reducing the growth of colon adenocarcinoma, osteosarcoma, and KB nasopharynx. 11 Isoindole-1,3-diones are also known for their antiviral, 12 antiinflammatory, 13 Chk1 inhibitory, 14 sedative, 15 bactericidal, and fungicidal 16 properties. They also find important applications as synthetic intermediates in the dye, 17 pesticide, 18 and polymer 19 industries.…”

2-Benzyl-5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione

“…properties, such as, antimicrobial activity (Zentz et al, 2002), antibacterial activity (Filho et al, 1994) and antitumor activity (Kratz et al, 1997). Some phthalimide derivatives had cytotoxicity (Hall et al, 1995) and anti-HIV activity (Van Derpoorten et al, 1997). It was assumed that compounds having both phthalimide and maleimide residues in the same molecule may possess some attractive biological activities.…”

EthylN-(2-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbamate

“…Functionalization of the carbamate moiety offers an attractive method for the generation of derivatives, which may have interesting medicinal and biological properties (Folkmann & Lund, 1990). We are interested in phthalimide derivatives and a search of the literature revealed that some phthalimide derivatives have cytotoxicity (Hall et al, 1995) and anti-HIV activity (Van Derpoorten et al, 1997). It has been assumed that compounds having both phthalimide and carbamate residues in the same molecule may possess some attractive biological activities.…”