The cytotoxicity of garlic-related disulphides and thiosulfonates in WHCO1 oesophageal cancer cells is dependent on S-thiolation and not production of ROS

Smith, Muneerah; Hunter, Roger; Stellenboom, Nashia; Kusza, Daniel A.; Parker, M. Iqbal; Hammouda, Ahmed N.; Jackson, Graham E.; Kaschula, Catherine H.

doi:10.1016/j.bbagen.2016.03.032

Cited by 43 publications

(38 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, recent studies have associated garlic consumption with preventive effects on human cancer (Chiavarini et al, 2016;de Giorgio and Stebbing, 2016;Kaschula et al, 2016;Myneni et al, 2016;Saud et al, 2016;Smith et al, 2016). The hypothesis underlying these studies may partially be explained by the anti-mutagenic and immune-modulatory effects of garlic derived allylsulfur compounds and their ability to exert a direct anti-proliferative effect on growing tumour cells by inducing apoptosis Powolny and Singh, 2008;Schafer and Kaschula, 2014).…”

Section: Bioactivity Perspectives and Applications Of Allium Sulfur mentioning

confidence: 95%

Stability and extraction of bioactive sulfur compounds from Allium genus processed by traditional and innovative technologies

Poojary

Putnik

Kovačević

et al. 2017

Journal of Food Composition and Analysis

119

View full text Add to dashboard Cite

Section: Bioactivity Perspectives and Applications Of Allium Sulfur mentioning

confidence: 95%

Stability and extraction of bioactive sulfur compounds from Allium genus processed by traditional and innovative technologies

Poojary

Putnik

Kovačević

et al. 2017

Journal of Food Composition and Analysis

119

View full text Add to dashboard Cite

“…This antioxidant protects cells from toxic effects of reactive species of oxygen (ROS) and elimination of xenobiotics. However, disulfides (RS‐SR) and thiosulfonates (RS‐S(O) 2 R) are able to act significantly through S ‐thiolation of GSH, leading to its oxidized form (RS‐SG) . This generates an expressive reduction of intracellular GSH and consequently, to the increase of ROS.…”

Section: Introductionmentioning

confidence: 99%

“…Hence, addressing alternative means for renal cancer treatment continues to be an important issue, and the search for new compounds that act selectively in chemoresistant cells is imperative. Compounds containing sulfur present cytotoxic potential against many tumor cell lines . Some that can be highlighted are the disulfide I, the thiosulfonate II and, the disulfide III that exhibit cytotoxic activity against esophageal cancer cells (Figure ).…”

Section: Introductionmentioning

confidence: 99%

S‐(4‐Methoxyphenyl)‐4‐methoxybenzenesulfonothioate as a Promising Lead Compound for the Development of a Renal Carcinoma Agent

et al. 2020

View full text Add to dashboard Cite

Organosulfur compounds show cytotoxic potential towards many tumor cell lines. Disulfides and thiosulfonates act through apoptotic processes, inducing proteins associated with apoptosis, endoplasmic reticulum stress, and the unfolded protein response. Three p‐substituted symmetric diaryl disulfides and three diaryl thiosulfonates were synthesized and analyzed for inhibition of tubulin polymerization and for human cancer cell cytotoxic activity against seven tumor cell lines and a non‐tumor cell line. S‐(4‐methoxyphenyl)‐4‐methoxybenzenesulfonothioate (6) exhibited inhibition of tubulin polymerization and showed the best antiproliferative potential, especially against the 786‐0 cell line, being six times more selective as compared with the non‐tumor cell line. In addition, compound 6 was able to activate caspase‐3 after 24 and 48 h treatments of the 786‐0 cell line and induced cell‐cycle arrest in the G2/M stage at the highest concentration evaluated at 24 and 48 h. Compound 6 was able to cause complete inhibition of proliferation, inducing the death of 786‐0 cells, by increasing the number of cells at G2/M and greater activation of caspase‐3.

show abstract

“…Model mononuclear analogues were also prepared. The cytotoxicity of all complexes were evaluated against the WHCO1 oesophageal squamous cell carcinoma cell line, due to its prevalence in many developing countries in Asia, South American and Africa …”

Section: Introductionmentioning

confidence: 99%

Tripodal Half‐Sandwich Rhodium and Iridium Complexes Containing Sulfonate and Pyridinyl Entities as Antitumor Agents

et al. 2017

Self Cite

View full text Add to dashboard Cite

In light of the widely used platinum anticancer drugs showing high toxicity and poor selectivity, the quest to develop new anticancer agents is increasing. This study investigated the synthesis of mononuclear and trinuclear RhIII and IrIII sulfonate‐containing pyridinyl complexes that have been fully characterized using NMR and IR spectroscopy, HR‐ESI‐mass spectrometry and elemental analysis. The cytotoxicities of all sulfonated pyridinyl compounds were investigated against a WHCO1 oesophageal cancer cell line and the metal complexes showed moderate activity, while the uncomplexed ligands were inactive. Several of the trinuclear complexes are of comparable activity to that of the clinical cancer drug cisplatin. 1H NMR model studies demonstrated the in vitro DNA binding ability of the most active complex.

show abstract

The cytotoxicity of garlic-related disulphides and thiosulfonates in WHCO1 oesophageal cancer cells is dependent on S-thiolation and not production of ROS

Cited by 43 publications

References 47 publications

Stability and extraction of bioactive sulfur compounds from Allium genus processed by traditional and innovative technologies

Stability and extraction of bioactive sulfur compounds from Allium genus processed by traditional and innovative technologies

S‐(4‐Methoxyphenyl)‐4‐methoxybenzenesulfonothioate as a Promising Lead Compound for the Development of a Renal Carcinoma Agent

Tripodal Half‐Sandwich Rhodium and Iridium Complexes Containing Sulfonate and Pyridinyl Entities as Antitumor Agents

Contact Info

Product

Resources

About