The cytotoxic effects of Scilla nervosa (Burch.) Jessop (Hyacinthaceae) aqueous extract on cultured HepG2 cells

Pillay, P Parameswaran; Phulukdaree, Alisa; Chuturgoon, Anil A.; Toit, Karen du; Bodenstein, Johannes

doi:10.1016/j.jep.2012.10.053

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…This may imply an interaction of one/more of the phytochemicals with DNA or with the mitotic apparatus. Several medicinal plants with many pharmacological activities have been reported to be genotoxic and/or mutagenic (Santos et al ., 2012 ; Pillay et al ., 2013 ; Alves et al ., 2014 ; Ferreira-Machado et al ., 2014 ). This is because crude extracts are composed of several phytochemicals which may work synergistically, antagonistically or additively.…”

Section: Discussionmentioning

confidence: 99%

Genotoxicity and antigenotoxicity study of aqueous and hydro-methanol extracts of Spondias mombin L., Nymphaea lotus L. and Luffa cylindrical L. using animal bioassays

Oyeyemi

Yekeen

Odusina

et al. 2015

Interdisciplinary Toxicology

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Spondias mombin (Linn), Nymphaea lotus (Linn) and Luffa cylindrica (Linn) (syn Luffa aegyptiaca Mill) are plants traditionally used as food ingredients and in the management of diseases, including cancer, in Nigeria. Despite the therapeutic potentials attributed to these plants, reports on their genotoxicity are scanty. In this study, the genotoxicity of the aqueous and hydro-methanol extract of these plants was evaluated using mouse bone marrow micronucleus and sperm morphology assays. Antigenotoxicity was assessed by the bone marrow micronucleus test. The highest attainable dose of 5 000 mg/kg according to OECD guidelines was first used to assess acute toxicity of the aqueous and hydro-methanol extracts in Swiss albino mice. For each extract, there were five groups of mice (n=4/group) treated with different concentrations of the extract as against the negative and positive control group for the genotoxicity study. In the antigenotoxicity study, five groups of mice were exposed to five different concentrations of the extracts along with 60 mg/kg of methyl methane sulfonate (MMS), which was used to induce genotoxicity. The mice were administered 0.2 mL of extract per day for 10 days in the genotoxicity and antigenotoxicity groups. Administration of each of the extracts at the concentration of 5 000 mg/kg did not induce acute toxicity in mice. At the concentrations tested, all the extracts, except aqueous S. mombin, increased micronucleated polychromatic erythrocytes. The aqueous and hydro-methanol extracts of N. lotus increased the frequency of aberrant sperm cells. All the extracts were also able to ameliorate MMS induced genotoxicity in bone marrow cells of the exposed mice. The results showed the potential of the extracts to induce somatic and germ cell mutation in male mice. The extracts also ameliorated the genotoxic effect of MMS.

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Section: Discussionmentioning

confidence: 99%

Genotoxicity and antigenotoxicity study of aqueous and hydro-methanol extracts of Spondias mombin L., Nymphaea lotus L. and Luffa cylindrical L. using animal bioassays

Oyeyemi

Yekeen

Odusina

et al. 2015

Interdisciplinary Toxicology

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“…Eucosterol 20 was found to be the major component, with compounds 21, 54, 169, 170 and 171 present in smaller amounts. 76,[81][82][83][84] Extensive work on the bulbs by Adinol et al resulted in the isolation of the free aglycones present in the bulbs (20,21,22,54,(169)(170)(171)(172)(173)(174)(175) [85][86][87][88][89] as well as the full structural elucidation of the glycosides (86, 87, 102, 103 and 176). [90][91][92][93][94] All the nortriterpenes isolated from Leopoldia comosa mentioned so far have S conguration at C-23, three compounds with R conguration have also been identied, 177, 91 178 (23R 20) and 179 (23R 170).…”

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confidence: 99%

“…172 There has been some evidence presented to indicate that the bulbs may cause damage to liver cells. 173 A homoisoavanone 400 has been isolated from Spetaea lachenaliiora Wetschnig & Pfosser (as Scilla plumbea Lindl.). This is a little known species, neither toxic nor known to be used by traditional healers.…”

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confidence: 99%

The chemistry and biological activity of the Hyacinthaceae

2013

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The Hyacinthaceae (sensu APGII), with approximately 900 species in about 70 genera, can be divided into three main subfamilies, the Hyacinthoideae, the Urgineoideae and the Ornithogaloideae, with a small fourth subfamily the Oziroëoideae, restricted to South America. The plants included in this family have long been used in traditional medicine for a wide range of medicinal applications. This, together with some significant toxicity to livestock has led to the chemical composition of many of the species being investigated. The compounds found are, for the most part, subfamily-restricted, with homoisoflavanones and spirocyclic nortriterpenoids characterising the Hyacinthoideae, bufadienolides characterising the Urgineoideae, and cardenolides and steroidal glycosides characterising the Ornithogaloideae. The phytochemical profiles of 38 genera of the Hyacinthaceae will be discussed as well as any biological activity associated with both crude extracts and compounds isolated. The Hyacinthaceae of southern Africa were last reviewed in 2000 (T. S. Pohl, N. R. Crouch and D. A. Mulholland, Curr. Org. Chem., 2000, 4, 1287-1324; ref. 1); the current contribution considers the family at a global level.

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Sappanin-type homoisoflavonoids from Scilla bisotunensis Speta.: Cytotoxicity, molecular docking, and chemotaxonomic significance

Ghoran

Firuzi²,

Pirhadi³

et al. 2023

Journal of Molecular Structure

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The cytotoxic effects of Scilla nervosa (Burch.) Jessop (Hyacinthaceae) aqueous extract on cultured HepG2 cells

Cited by 6 publications

References 22 publications

Genotoxicity and antigenotoxicity study of aqueous and hydro-methanol extracts of Spondias mombin L., Nymphaea lotus L. and Luffa cylindrical L. using animal bioassays

Genotoxicity and antigenotoxicity study of aqueous and hydro-methanol extracts of Spondias mombin L., Nymphaea lotus L. and Luffa cylindrical L. using animal bioassays

The chemistry and biological activity of the Hyacinthaceae

Sappanin-type homoisoflavonoids from Scilla bisotunensis Speta.: Cytotoxicity, molecular docking, and chemotaxonomic significance

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