The cytoplasmic fatty-acid-binding proteins: thirty years and counting

Abstract

The interest in fatty-acid-binding proteins has produced about 1000 research papers since their discovery nearly 30 years ago. This review provides an entry to the mammalian and nonmammalian literature through a compendium of categorized review articles (nearly 60). Publications that have not yet been reviewed, particularly of function and modes of action, are presented and discussed in light of earlier reports. This large protein family may be integral in the relationship between lipid and carbohydrate metabolism.

New insights into the structure and function of fatty acid-binding proteins

“…26]. The presence of FABPs has been established in many non-mammalian tissues, but the pattern of tissue expression is different from mammals [7]. We will largely omit discussion of the non-mammalian FABPs, since recent reviews have elaborated extensively on this subject [7,26].…”

“…Only recently have studies on knockout mice provided direct proof for the importance of FABPs in the uptake and transport of long-chain FAs and their interaction with other transport systems and enzymes. Numerous reviews on structural and functional aspects of the FABP family have appeared over the last 10 -15 years [7]. We will focus mainly on recent data on the structure of FABPs, their role in FA uptake and transport and their involvement in the modulation of several cellular processes including signal transduction, gene expression, growth and differentiation.…”

In situ heparin‐induced peroxisomal reticulum and biogenesis of peroxisomes in pulmonary intravascular macrophages (PIMs) of caprine lung: an ultrastructural and cytochemical study

“…The FFAs play an important role in cell homeostasis by serving as a metabolic energy source and building blocks for membrane lipids, thus regulating various cell functions (Stewart, 2000). Increasing evidence suggests that plasma membrane-associated and cytoplasmic fatty acid binding proteins are involved in the uptake and intracellular transport system of FFAs (DuttaRoy, 2000;Stewart, 2000;Kennedy, 2000).…”

Physiological Responses to Fasting in Bats

“…17). One factor significantly affecting lipid mobilization is the activity and concentration of fatty acid binding proteins that play an important role in intracellular transport of fatty acid (Stewart 2000). The little brown bat, Myotis lucifugus, has been reported to undergo modifications in fatty acid binding proteins during hibernation that may increase the efficiency of lipid mobilization (Eddy and Storey 2004).…”