The cytopathologic features of mammary analog secretory carcinoma and its mimics

Samulski, T. Danielle; LiVolsi, Virginia A.; Baloch, Zubair W.

doi:10.4103/1742-6413.139726

Cited by 32 publications

(25 citation statements)

References 10 publications

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“…17 For our case, several differential diagnoses should be considered. The most important differential diagnosis is secretory carcinoma of the breast.…”

Section: Discussionmentioning

confidence: 95%

“Secretory” Carcinoma of the Skin Mimicking Secretory Carcinoma of the Breast: Case Report and Literature Review

Huang

Liu

et al. 2016

The American Journal of Dermatopathology

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Secretory carcinoma is a unique kind of adenocarcinoma. It has distinct histological features and a special genetic change, that is, t (12; 15) (p13; q25) translocation which leads to the expression of the ETV6-NTRK3 fusion gene. Secretory carcinoma has been found to occur both in the breast and salivary gland. Here the authors present a case of 22-year-old woman with a unique cutaneous neoplasm located at the axilla. The tumor was characterized histologically with the formation of round to ovoid microcysts and papillary structure, which was similar to the secretory carcinoma of the breast and salivary gland. Furthermore, the gene sequence analysis of reverse-transcription polymerase chain reaction products demonstrated the expression of the ETV6-NTRK3 fusion gene. To the authors' knowledge, this is the first case of secretory carcinoma from the skin which has the same genetic change as those from the breast and salivary gland. Local excision was performed on this patient. She had been followed up for nearly 1 year. No recurrence or metastasis was found yet.

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“…17 For our case, several differential diagnoses should be considered. The most important differential diagnosis is secretory carcinoma of the breast.…”

Section: Discussionmentioning

confidence: 95%

“Secretory” Carcinoma of the Skin Mimicking Secretory Carcinoma of the Breast: Case Report and Literature Review

Huang

Liu

et al. 2016

The American Journal of Dermatopathology

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“…2 As the name would suggest, MASC morphologically mimics secretory carcinoma of breast by histology. 4,[6][7][8][9][10] Prior to our case report, few cases of MASC involving the thyroid have been reported. Common elements in papers detailing cytologic findings of MASC include dispersed or loosely cohesive histiocytoid cells, abundant vaculoated eosinophilic cytoplasm, variably eccentric nuclei with fine chromatin, variably sized nucleoli, and background pale-staining seromucinous material.…”

Section: Introductionmentioning

confidence: 93%

Mammary analog secretory carcinoma of thyroid: A case report

Rupp

Bocklage

2016

Diagnostic Cytopathology

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Mammary analog secretory carcinoma (MASC) is a recently described rare neoplasm that was first reported in the salivary gland with an associated ETV6-NTRK3 fusion. We present a case of MASC involving and presumably arising in the thyroid, which was originally diagnosed as papillary thyroid carcinoma on fine needle aspiration and surgical resection. The later correct diagnosis of MASC was confirmed by immunohistochemistry and molecular studies. The cytopathological features of MASC in the salivary gland are previously described; however, we present the first cytopathological description of MASC arising in the thyroid with the unique feature of prominent nuclear grooves. Differentiating MASC from overlapping features of cytopathologic mimics such as papillary thyroid carcinoma may carry crucial therapeutic implications. Diagn. Cytopathol. 2017;45:45-50. © 2016 Wiley Periodicals, Inc.

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“…Papillary architecture with transgressing vessels, microcystic pattern along with bubbly cytoplasm, lack of intermediate and squamous cells facilitate the distinction from MEC [14][15][16][17][18][19][20] (Table III) Table IV. IHC and molecular studies are useful in differentiating MASC from its mimics and confirming the diagnosis. However, predominant microcystic pattern with eosinophilic secretions, abundant bubbly cytoplasm, cells with single intra-cytoplasmic mucin vacuole and cellular hob nailing facilitate distinction form acinic AcCC.…”

Section: Discussionmentioning

confidence: 99%

Mammary analogue secretory carcinoma of parotid: Is preoperative cytological diagnosis possible?

Oza

Sanghvi

Shet

et al. 2016

Diagnostic Cytopathology

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Mammary analogue secretory carcinoma is a recently recognized tumor of salivary gland with characteristic t(12;15)(q13;q25) that results in ETV6-NTRK3 fusion product. Distinguishing mammary analogue secretory carcinoma from other salivary gland tumors is important. Present study highlights cytologic findings in three cases of mammary analogue secretory carcinoma of parotid which facilitate preoperative diagnosis with the aid of ancillary diagnostic techniques. Fine needle aspiration cytology of parotid was performed on three cases after clinical examination. Immunocytochemistry for mammoglobin and S100 were performed. Parotidectomy was done in all cases. The corresponding hematoxylin and eosin stained slides and blocks of all cases were studied. Molecular analysis was done in one of the cases. Cases 1 and 3 revealed uniform atypical epithelial cells arranged in branching papillary pattern with few cells in microcystic pattern. Case 2 showed atypical cells arranged mainly in loose clusters and few singly dissociated. Individual cells revealed round nuclei, vesicular chromatin, prominent nucleoli and abundant finely vacuolated cytoplasm with metachromasia prominent in May-Grunwald-Giemsa smear (case 3). Characteristic hob-nail cells covering papillae were observed in cases 1 and 3. Immunocytochemistry showed strong positivity for mammoglobin and S100 thereby confirming the diagnosis of mammary analogue secretory carcinoma preoperatively. The diagnosis was in concordance with surgical specimen. Also, characteristic ETV6-NTRK3 translocation was confirmed in case 1. Increased awareness and high index of suspicion is necessary for the upfront diagnosis, more so for the papillary variant of mammary analogue secretory carcinoma. Immunocytochemistry aids in confirming this preoperative diagnosis, based on which treatment can be planned. Diagn. Cytopathol. 2016;44:519-525. © 2016 Wiley Periodicals, Inc.

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The cytopathologic features of mammary analog secretory carcinoma and its mimics

Cited by 32 publications

References 10 publications

“Secretory” Carcinoma of the Skin Mimicking Secretory Carcinoma of the Breast: Case Report and Literature Review

“Secretory” Carcinoma of the Skin Mimicking Secretory Carcinoma of the Breast: Case Report and Literature Review

Mammary analog secretory carcinoma of thyroid: A case report

Mammary analogue secretory carcinoma of parotid: Is preoperative cytological diagnosis possible?

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